Identification of New Cytotoxic T-Cell Epitopes on the 38-Kilodalton Lipoglycoprotein of Mycobacterium tuberculosis by Using Lipopeptides

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Published inInfection and Immunity Vol. 66; no. 7; pp. 3190 - 3197
Main Authors DA FONSECA, D. P. A. J, JOOSTEN, D, VAN DER ZEE, R, JUE, D. L, SINGH, M, VORDERMEIER, H. M, SNIPPE, H, VERHEUL, A. F. M
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.07.1998
Subjects
Animals
Bacteriology
Biological and medical sciences
Epitopes, T-Lymphocyte
Female
Fundamental and applied biological sciences. Psychology
Glycoproteins - immunology
H-2 Antigens - biosynthesis
Histocompatibility Antigen H-2D
Lipoproteins - immunology
Mice
Mice, Inbred C57BL
Microbial Immunity and Vaccines
Microbiology
Molecular Weight
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
T-Lymphocytes, Cytotoxic - immunology
Tumor Cells, Cultured
Antigenic determinant
Major histocompatibility system
Cytotoxicity
Cellular immunity
H-2-System
Specificity
Immunogenicity
Mycobacterium tuberculosis
Mycobacteriales
T-Lymphocyte
Mycobacteriaceae
Bacteria
Actinomycetes
Class I histocompatibility antigen
Lipopeptide
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Abstract Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
AbstractList Induction of cytotoxic T lymphocytes (CTLs) by vaccination has been shown to protect against bacterial, viral, and tumoral challenge. The aim of this study was to identify CTL epitopes on the 38-kDa lipoglycoprotein from Mycobacterium tuberculosis. The identification of these CTL epitopes was based on synthesizing peptides designed from the 38-kDa lipoglycoprotein, with known major histocompatibility complex class I (MHC-I) binding motifs (H-2D super(b)), and studying their ability to up-regulate and stabilize MHC-I molecules on the mouse lymphoma cell line RMA-S. To improve the capacity of the identified peptides to induce CTL responses in mice, palmitic acid with a cysteine-serine-serine spacer amino acid sequence was attached to the amino terminus of the peptide. Two of five peptides with H-2D super(b) binding motifs and their corresponding lipopeptides up-regulated and stabilized the H-2D super(b) molecules on RMA-S cells. Both lipopeptides, in combination with incomplete Freund's adjuvant, induced CTL responses in C57BL/6 (H-2 super(b)) mice. Moreover, the lipopeptide induced stronger CTL responses than the peptide. The capacity of the various lipopeptides to induce CTL displayed a good relationship with the ability of the (lipo)peptide to up-regulate and to stabilize H-2D super(b) molecules. The capacity of the peptides and lipopeptides to up-regulate and stabilize MHC-I expression can therefore be used to predict their potential to function as a CTL epitope. The newly identified CTL epitopes and their lipid derivatives provide us with important information for future M. tuberculosis vaccine design.
Induction of cytotoxic T lymphocytes (CTLs) by vaccination has been shown to protect against bacterial, viral, and tumoral challenge. The aim of this study was to identify CTL epitopes on the 38-kDa lipoglycoprotein from Mycobacterium tuberculosis . The identification of these CTL epitopes was based on synthesizing peptides designed from the 38-kDa lipoglycoprotein, with known major histocompatibility complex class I (MHC-I) binding motifs (H-2D b ), and studying their ability to up-regulate and stabilize MHC-I molecules on the mouse lymphoma cell line RMA-S. To improve the capacity of the identified peptides to induce CTL responses in mice, palmitic acid with a cysteine-serine-serine spacer amino acid sequence was attached to the amino terminus of the peptide. Two of five peptides with H-2D b binding motifs and their corresponding lipopeptides up-regulated and stabilized the H-2D b molecules on RMA-S cells. Both lipopeptides, in combination with incomplete Freund’s adjuvant, induced CTL responses in C57BL/6 (H-2 b ) mice. Moreover, the lipopeptide induced stronger CTL responses than the peptide. The capacity of the various lipopeptides to induce CTL displayed a good relationship with the ability of the (lipo)peptide to up-regulate and to stabilize H-2D b molecules. The capacity of the peptides and lipopeptides to up-regulate and stabilize MHC-I expression can therefore be used to predict their potential to function as a CTL epitope. The newly identified CTL epitopes and their lipid derivatives provide us with important information for future M. tuberculosis vaccine design.
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Induction of cytotoxic T lymphocytes (CTLs) by vaccination has been shown to protect against bacterial, viral, and tumoral challenge. The aim of this study was to identify CTL epitopes on the 38-kDa lipoglycoprotein from Mycobacterium tuberculosis. The identification of these CTL epitopes was based on synthesizing peptides designed from the 38-kDa lipoglycoprotein, with known major histocompatibility complex class I (MHC-I) binding motifs (H-2Db), and studying their ability to up-regulate and stabilize MHC-I molecules on the mouse lymphoma cell line RMA-S. To improve the capacity of the identified peptides to induce CTL responses in mice, palmitic acid with a cysteine-serine-serine spacer amino acid sequence was attached to the amino terminus of the peptide. Two of five peptides with H-2Db binding motifs and their corresponding lipopeptides up-regulated and stabilized the H-2Db molecules on RMA-S cells. Both lipopeptides, in combination with incomplete Freund's adjuvant, induced CTL responses in C57BL/6 (H-2(b)) mice. Moreover, the lipopeptide induced stronger CTL responses than the peptide. The capacity of the various lipopeptides to induce CTL displayed a good relationship with the ability of the (lipo)peptide to up-regulate and to stabilize H-2Db molecules. The capacity of the peptides and lipopeptides to up-regulate and stabilize MHC-I expression can therefore be used to predict their potential to function as a CTL epitope. The newly identified CTL epitopes and their lipid derivatives provide us with important information for future M. tuberculosis vaccine design.
Author Dianne Joosten
Dora P. A. J. da Fonseca
Hans M. Vordermeier
Danny L. Jue
Mahavir Singh
André F. M. Verheul
Harm Snippe
Ruurd van der Zee
AuthorAffiliation Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Section Vaccines, Academic Hospital Utrecht, Utrecht University, 3584 CX Utrecht, 1 and Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, 3508 TD Utrecht, 2 The Netherlands; Biotechnology Core Facility, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333 3 ; GBF—German National Research Center for Biotechnology, 38124 Braunschweig, Germany 4 ; and Veterinary Laboratories Agency, Bacteriology, TB Research Group, New Haw, Addlestone, Surrey KT13 3NB, United Kingdom 5
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  surname: VERHEUL
  fullname: VERHEUL, A. F. M
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Cites_doi 10.1002/eji.1830230929
10.1002/eji.1830201219
10.1073/pnas.89.24.12013
10.1002/eji.1830221024
10.1016/0952-7915(94)90028-0
10.1038/nm0896-888
10.1046/j.1365-3083.1997.d01-432.x
10.1002/eji.1830180110
10.1111/j.1399-3011.1992.tb00299.x
10.1093/intimm/5.11.1489
10.1038/346476a0
10.1016/0167-5699(88)91292-3
10.1046/j.1365-3083.1996.d01-340.x
10.4049/jimmunol.148.6.1871
10.1002/eji.1830211102
10.4049/jimmunol.153.12.5586
10.1016/0092-8674(93)90472-3
10.4049/jimmunol.147.3.1023
10.1084/jem.176.6.1611
10.1002/eji.1830250431
10.1038/342561a0
10.1016/0923-2508(91)90097-T
10.1002/eji.1830221209
10.1038/361359a0
10.1111/j.1365-2362.1995.tb01716.x
10.1126/science.257.5073.1055
10.4049/jimmunol.158.12.5921
10.1016/0161-5890(94)90155-4
10.1016/0264-410X(95)00084-E
10.1093/intimm/7.4.559
10.4049/jimmunol.156.11.4182
10.1002/eji.1830181203
10.1378/chest.103.6.1641
10.1016/0264-410X(89)90007-8
10.1046/j.1365-2567.1996.512590.x
10.4049/jimmunol.149.10.3416
10.1128/iai.54.1.177-183.1986
10.1016/0022-1759(92)90322-K
10.1002/j.2326-1951.1993.tb03118.x
10.1016/0022-1759(95)00052-C
10.1093/intimm/9.11.1669
10.1002/eji.1830250637
10.1016/0264-410X(95)93320-9
10.1038/341323a0
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Issue 7
Keywords Antigenic determinant
Major histocompatibility system
Cytotoxicity
Cellular immunity
H-2-System
Specificity
Immunogenicity
Mycobacterium tuberculosis
Mycobacteriales
T-Lymphocyte
Mycobacteriaceae
Bacteria
Actinomycetes
Class I histocompatibility antigen
Lipopeptide
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Editor: R. N. Moore
Corresponding author. Mailing address: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Section Vaccines, AZU, Rm. G04.614, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Phone: 31-30-2506525. Fax: 31-30-2541770. E-mail: D.Fonseca@lab.azu.nl.
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References 7513522 - Curr Opin Immunol. 1994 Feb;6(1):13-23
1281212 - J Exp Med. 1992 Dec 1;176(6):1611-8
2470215 - Vaccine. 1989 Feb;7(1):29-33
7537671 - Eur J Immunol. 1995 Apr;25(4):1063-70
7540640 - J Immunol Methods. 1995 Jun 9;182(2):219-26
1517589 - J Immunol Methods. 1992 Aug 30;153(1-2):193-200
1906192 - Res Microbiol. 1991 Jan;142(1):55-65
1282504 - Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):255-60
1446701 - Eur J Immunol. 1992 Dec;22(12):3085-90
1396968 - Eur J Immunol. 1992 Oct;22(10):2631-7
2428751 - Infect Immun. 1986 Oct;54(1):177-83
2586628 - Nature. 1989 Nov 30;342(6249):561-4
1936113 - Eur J Immunol. 1991 Nov;21(11):2649-54
7527444 - J Immunol. 1994 Dec 15;153(12):5586-92
7823965 - Mol Immunol. 1994 Dec;31(18):1391-401
7656913 - Eur J Clin Invest. 1995 Jun;25(6):371-7
8778016 - Immunology. 1996 Mar;87(3):339-42
2477703 - Nature. 1989 Sep 28;341(6240):323-6
1385524 - J Immunol. 1992 Nov 15;149(10):3416-22
8947600 - Scand J Immunol. 1996 Nov;44(5):485-92
7505110 - Int Immunol. 1993 Nov;5(11):1489-92
1465432 - Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12013-7
8404075 - Chest. 1993 Jun;103(6):1641-2
1509256 - Science. 1992 Aug 21;257(5073):1055-64
7678924 - Nature. 1993 Jan 28;361(6410):359-62
9190945 - J Immunol. 1997 Jun 15;158(12):5921-6
1541825 - J Immunol. 1992 Mar 15;148(6):1871-8
7547682 - Int Immunol. 1995 Apr;7(4):559-66
8578845 - Vaccine. 1995 Nov;13(16):1576-82
9160097 - Scand J Immunol. 1997 May;45(5):521-6
2269329 - Eur J Immunol. 1990 Dec;20(12):2651-9
2198471 - Nature. 1990 Aug 2;346(6283):476-80
7631520 - Vaccine. 1995 Feb;13(3):313-20
3146508 - Eur J Immunol. 1988 Dec;18(12):1881-7
1705236 - Immunology. 1991 Jan;72(1):109-13
7690326 - Eur J Immunol. 1993 Sep;23(9):2242-9
8104103 - Cell. 1993 Sep 10;74(5):929-37
8666786 - J Immunol. 1996 Jun 1;156(11):4182-90
7615001 - Eur J Immunol. 1995 Jun;25(6):1739-43
2450033 - Eur J Immunol. 1988 Jan;18(1):59-66
3151440 - Immunol Today. 1988 Jun;9(6):168-74
1713602 - J Immunol. 1991 Aug 1;147(3):1023-9
8705858 - Nat Med. 1996 Aug;2(8):888-92
9418128 - Int Immunol. 1997 Nov;9(11):1669-76
e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_28_2
e_1_3_2_40_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_24_2
e_1_3_2_46_2
Song R. (e_1_3_2_30_2) 1996; 156
Zhu X. (e_1_3_2_47_2) 1997; 158
Martinon F. (e_1_3_2_19_2) 1992; 149
e_1_3_2_9_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_37_2
Weismuller K.-H. (e_1_3_2_41_2) 1991; 72
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_39_2
Sette A. (e_1_3_2_29_2) 1994; 153
Vordermeier H. M. (e_1_3_2_35_2) 1991; 147
e_1_3_2_32_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_2_2
e_1_3_2_14_2
Romero P. (e_1_3_2_25_2) 1992; 148
Kauffman S. H. E. (e_1_3_2_15_2) 1993; 1
References_xml – ident: e_1_3_2_10_2
  doi: 10.1002/eji.1830230929
– ident: e_1_3_2_13_2
  doi: 10.1002/eji.1830201219
– ident: e_1_3_2_12_2
  doi: 10.1073/pnas.89.24.12013
– ident: e_1_3_2_36_2
  doi: 10.1002/eji.1830221024
– ident: e_1_3_2_9_2
  doi: 10.1016/0952-7915(94)90028-0
– ident: e_1_3_2_32_2
  doi: 10.1038/nm0896-888
– ident: e_1_3_2_39_2
  doi: 10.1046/j.1365-3083.1997.d01-432.x
– ident: e_1_3_2_5_2
  doi: 10.1002/eji.1830180110
– volume: 72
  start-page: 109
  year: 1991
  ident: e_1_3_2_41_2
  article-title: The antibody response in BALB/c mice to the Plasmodium falciparum circumsporozoite repetitive epitope covalently coupled to synthetic lipopeptide adjuvant.
  publication-title: Immunology
  contributor:
    fullname: Weismuller K.-H.
– ident: e_1_3_2_42_2
  doi: 10.1111/j.1399-3011.1992.tb00299.x
– ident: e_1_3_2_8_2
  doi: 10.1093/intimm/5.11.1489
– ident: e_1_3_2_18_2
  doi: 10.1038/346476a0
– ident: e_1_3_2_14_2
  doi: 10.1016/0167-5699(88)91292-3
– ident: e_1_3_2_21_2
  doi: 10.1046/j.1365-3083.1996.d01-340.x
– volume: 148
  start-page: 1871
  year: 1992
  ident: e_1_3_2_25_2
  article-title: Immunization with synthetic peptides containing a defined malaria epitope induces highly diverse cytotoxic T lymphocyte responses.
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.148.6.1871
  contributor:
    fullname: Romero P.
– ident: e_1_3_2_27_2
  doi: 10.1002/eji.1830211102
– volume: 153
  start-page: 5586
  year: 1994
  ident: e_1_3_2_29_2
  article-title: The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.153.12.5586
  contributor:
    fullname: Sette A.
– ident: e_1_3_2_26_2
  doi: 10.1016/0092-8674(93)90472-3
– volume: 147
  start-page: 1023
  year: 1991
  ident: e_1_3_2_35_2
  article-title: Identification of T cell stimulatory peptides from the 38-kDa protein of Mycobacterium tuberculosis.
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.147.3.1023
  contributor:
    fullname: Vordermeier H. M.
– ident: e_1_3_2_4_2
  doi: 10.1084/jem.176.6.1611
– ident: e_1_3_2_28_2
  doi: 10.1002/eji.1830250431
– ident: e_1_3_2_31_2
– ident: e_1_3_2_6_2
  doi: 10.1038/342561a0
– ident: e_1_3_2_44_2
  doi: 10.1016/0923-2508(91)90097-T
– ident: e_1_3_2_45_2
  doi: 10.1002/eji.1830221209
– ident: e_1_3_2_22_2
  doi: 10.1038/361359a0
– volume: 1
  start-page: 109
  year: 1993
  ident: e_1_3_2_15_2
  article-title: Tuberculosis, the role of the immune system.
  publication-title: Immunologist
  contributor:
    fullname: Kauffman S. H. E.
– ident: e_1_3_2_20_2
  doi: 10.1111/j.1365-2362.1995.tb01716.x
– ident: e_1_3_2_3_2
  doi: 10.1126/science.257.5073.1055
– volume: 158
  start-page: 5921
  year: 1997
  ident: e_1_3_2_47_2
  article-title: Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection.
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.158.12.5921
  contributor:
    fullname: Zhu X.
– ident: e_1_3_2_11_2
  doi: 10.1016/0161-5890(94)90155-4
– ident: e_1_3_2_38_2
  doi: 10.1016/0264-410X(95)00084-E
– ident: e_1_3_2_37_2
  doi: 10.1093/intimm/7.4.559
– volume: 156
  start-page: 4182
  year: 1996
  ident: e_1_3_2_30_2
  article-title: Roles of proteasomes, transporter for antigen presentation (TAP), and β2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway.
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.156.11.4182
  contributor:
    fullname: Song R.
– ident: e_1_3_2_23_2
  doi: 10.1002/eji.1830181203
– ident: e_1_3_2_16_2
  doi: 10.1378/chest.103.6.1641
– ident: e_1_3_2_40_2
  doi: 10.1016/0264-410X(89)90007-8
– ident: e_1_3_2_33_2
  doi: 10.1046/j.1365-2567.1996.512590.x
– volume: 149
  start-page: 3416
  year: 1992
  ident: e_1_3_2_19_2
  article-title: Immunization of mice with lipopeptides bypasses the prerequisite for adjuvant.
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.149.10.3416
  contributor:
    fullname: Martinon F.
– ident: e_1_3_2_43_2
  doi: 10.1128/iai.54.1.177-183.1986
– ident: e_1_3_2_46_2
  doi: 10.1016/0022-1759(92)90322-K
– ident: e_1_3_2_7_2
  doi: 10.1002/j.2326-1951.1993.tb03118.x
– ident: e_1_3_2_34_2
  doi: 10.1016/0022-1759(95)00052-C
– ident: e_1_3_2_48_2
  doi: 10.1093/intimm/9.11.1669
– ident: e_1_3_2_2_2
  doi: 10.1002/eji.1830250637
– ident: e_1_3_2_17_2
  doi: 10.1016/0264-410X(95)93320-9
– ident: e_1_3_2_24_2
  doi: 10.1038/341323a0
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Induction of cytotoxic T lymphocytes (CTLs) by vaccination has been shown to protect against bacterial, viral, and tumoral challenge. The aim of this study was...
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SubjectTerms Animals
Bacteriology
Biological and medical sciences
Epitopes, T-Lymphocyte
Female
Fundamental and applied biological sciences. Psychology
Glycoproteins - immunology
H-2 Antigens - biosynthesis
Histocompatibility Antigen H-2D
Lipoproteins - immunology
Mice
Mice, Inbred C57BL
Microbial Immunity and Vaccines
Microbiology
Molecular Weight
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
T-Lymphocytes, Cytotoxic - immunology
Tumor Cells, Cultured
Title Identification of New Cytotoxic T-Cell Epitopes on the 38-Kilodalton Lipoglycoprotein of Mycobacterium tuberculosis by Using Lipopeptides
URI http://iai.asm.org/content/66/7/3190.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9632585
https://search.proquest.com/docview/17104938
https://search.proquest.com/docview/79951165
https://pubmed.ncbi.nlm.nih.gov/PMC108332
Volume 66
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