Experimental Pain in Healthy Human Subjects Gender Differences in Nociception and in Response to Ibuprofen

• Published in: Anesthesia and analgesia Vol. 86; no. 6; pp. 1257 - 1262
• Main Authors: Walker, Judith S., Carmody, John J.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.06.1998
• Subjects: Adolescent; Adult; Analgesics; Analgesics - pharmacokinetics; Analgesics - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biological and medical sciences; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Ear, External - innervation; Electric Stimulation; Female; Humans; Ibuprofen - pharmacokinetics; Ibuprofen - therapeutic use; Linear Models; Male; Medical sciences; Neuropharmacology; Nociceptors - drug effects; Nociceptors - physiology; Pain - physiopathology; Pain - prevention & control; Pain Threshold - drug effects; Pain Threshold - physiology; Pharmacology. Drug treatments; Placebos; Sex Characteristics; Skin - innervation; Human; Nociception; Sex; Non steroidal antiinflammatory agent; Chemotherapy; Analgesic; Arylacetic acid derivatives; Pain; Treatment; Activity concentration relation; Ibuprofen; Pharmacokinetics; Comparative study

We used electrically induced pain in healthy young subjects to study gender differences in nociception and the analgesic efficacy of ibuprofen. Cutaneous stimulation of the earlobe allowed measurement of pain detection thresholds and maximal pain tolerance. Drug and placebo were each administered tw...