Gut reactions: How the blood–brain barrier connects the microbiome and the brain

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 243; no. 2; pp. 159 - 165
• Main Authors: Logsdon, Aric F, Erickson, Michelle A, Rhea, Elizabeth M, Salameh, Therese S, Banks, William A
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2018
• Subjects: Animals; Bacteria - metabolism; Bacterial Translocation; Biological Products - metabolism; Blood-Brain Barrier; Central Nervous System - drug effects; Central Nervous System - pathology; Central Nervous System - physiology; Gastrointestinal Microbiome; Gastrointestinal Tract - microbiology; Humans; Immunology/Microbiology/Virology; immune system; blood–brain barrier; T-cell; multiple sclerosis; Microbiome

A growing body of evidence indicates that the microbiome interacts with the central nervous system (CNS) and can regulate many of its functions. One mechanism for this interaction is at the level of the blood–brain barriers (BBBs). In this minireview, we examine the several ways the microbiome is kn...