Clinical symptoms and platelet monoamine oxidase in subgroups and different states of affective disorders
Platelet monoamine oxidase activity (MAO) and clinical symptoms were examined in 116 individuals, 32 acute depressed patients and 84 healthy controls. The enzyme activity was lower in depressed women than controls. MAO activity correlated positively with rated clinical state in depressed women but n...
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Published in | Journal of affective disorders Vol. 35; no. 1; pp. 75 - 87 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
09.10.1995
Elsevier |
Subjects | |
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Abstract | Platelet monoamine oxidase activity (MAO) and clinical symptoms were examined in 116 individuals, 32 acute depressed patients and 84 healthy controls. The enzyme activity was lower in depressed women than controls. MAO activity correlated positively with rated clinical state in depressed women but not in depressed men. Patients were reexamined after 10 years and categorized into affective psychosis (endogenous) or neurotic depression (International Statistical Classification of Diseases, Injuries and Causes of Death, 1987; ICD-9). Neurotic depressed occurred frequently in the low activity group. Endogenously depressed showed positive correlation between MAO activity and rated clinical state. The association between platelet MAO activity and clinical state is discussed. |
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AbstractList | Platelet monoamine oxidase activity (MAO) and clinical symptoms were examined in 116 individuals, 32 acute depressed patients and 84 healthy controls. The enzyme activity was lower in depressed women than controls. MAO activity correlated positively with rated clinical state in depressed women but not in depressed men. Patients were reexamined after 10 years and categorized into affective psychosis (endogenous) or neurotic depression (International Statistical Classification of Diseases, Injuries and Causes of Death, 1987; ICD-9). Neurotic depressed occurred frequently in the low activity group. Endogenously depressed showed positive correlation between MAO activity and rated clinical state. The association between platelet MAO activity and clinical state is discussed. |
Author | Wetterberg, L. Wahlund, B. Sääf, J. |
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Keywords | Affective disorder Clinical symptom Vulnerability Monoamine oxidase Human Mood disorder Symptomatology Clinical stage Enzymatic activity Enzyme Clinical form Depression Oxidoreductases Amine oxidase (flavin-containing) |
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SubjectTerms | Adult Adult and adolescent clinical studies Affective disorder Affective Disorders, Psychotic - classification Affective Disorders, Psychotic - diagnosis Affective Disorders, Psychotic - enzymology Affective Disorders, Psychotic - psychology Aged Biological and medical sciences Bipolar Disorder - classification Bipolar Disorder - diagnosis Bipolar Disorder - enzymology Bipolar Disorder - psychology Blood Platelets - enzymology Clinical symptom Depression Depressive Disorder - classification Depressive Disorder - diagnosis Depressive Disorder - enzymology Depressive Disorder - psychology Female Follow-Up Studies Humans Male Medical sciences Medicin och hälsovetenskap Middle Aged Monoamine oxidase Monoamine Oxidase - blood Mood disorders Patient Admission Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Risk Factors Vulnerability |
Title | Clinical symptoms and platelet monoamine oxidase in subgroups and different states of affective disorders |
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