Presynaptic Rac1 in the hippocampus selectively regulates working memory

• Published in: eLife Vol. 13
• Main Authors: Kim, Jaebin, Bustamante, Edwin, Sotonyi, Peter, Maxwell, Nicholas, Parameswaran, Pooja, Kent, Julie K, Wetsel, William C, Soderblom, Erik J, Rácz, Bence, Soderling, Scott H
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 24.07.2024; eLife Sciences Publications, Ltd
• Subjects: Actin; Animals; Autism; Behavior; Cell Biology; Cognitive ability; Cytoskeleton; Hippocampal plasticity; Hippocampus; Hippocampus - metabolism; Hippocampus - physiology; Intracellular signalling; Kinases; Localization; Male; Mass spectroscopy; Memory; Memory, Short-Term - physiology; Mice; Mice, Inbred C57BL; Morphology; Mutation; Neuronal Plasticity - physiology; Neurons; Neuropeptides - genetics; Neuropeptides - metabolism; Neuroscience; Phosphorylation; Post-translation; presynaptic; Presynaptic Terminals - metabolism; Presynaptic Terminals - physiology; Proteomics; Rac1; rac1 GTP-Binding Protein - genetics; rac1 GTP-Binding Protein - metabolism; Rac1 protein; Short term memory; short-term plasticity; Signal Transduction; Spatial memory; Synaptic vesicles; Ultrastructure; working memory; mouse; cell biology; hippocampus; working memory; neuroscience; presynaptic; Rac1; short-term plasticity

One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have shown that Rac1-mediated signaling is associated with hippocampal-dependent working memory...