Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

• Published in: eLife Vol. 12
• Main Authors: Kilic, Ayse, Halu, Arda, De Marzio, Margherita, Maiorino, Enrico, Duvall, Melody G, Bruggemann, Thayse Regina, Rojas Quintero, Joselyn J, Chase, Robert, Mirzakhani, Hooman, Sungur, Ayse Özge, Koepke, Janine, Nakano, Taiji, Peh, Hong Yong, Krishnamoorthy, Nandini, Abdulnour, Raja-Elie, Georgopoulos, Katia, Litonjua, Augusto A, Demay, Marie, Renz, Harald, Levy, Bruce D, Weiss, Scott T
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 03.04.2024; eLife Sciences Publications, Ltd
• Subjects: Animals; Asthma; Autoimmune diseases; Binding sites; CD4 antigen; Dietary supplements; Disease; Gene loci; Genetics and Genomics; Genomes; Genotype & phenotype; Helper cells; Humans; Immune system; Immunology and Inflammation; Immunomodulation; Immunoregulation; Inflammation; Inflammatory diseases; Interleukin 2; Lymphocytes T; Mice; Pneumonia; Polymorphism; Pregnancy; Prenatal experience; Stat5 protein; Th2 Cells; Vitamin D; Vitamin D - pharmacology; Vitamin D Deficiency - metabolism; vitamin D receptor; Vitamin D receptors; Vitamin deficiency; Vitamins; Womens health; United States > US; California; mouse; genetics; inflammation; genomics; asthma; vitamin D receptor; human; immunology

Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do not provide insight into the molecular genetic mechanisms of vitamin D-mediate...