The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies - Janas, Maja M.; Harbison, Carole E.; Perry, Victoria K.; Carito, Brenda; Sutherland, Jessica E.; Vaishnaw, Akshay K.; Keirstead, Natalie D.; Warner, Garvin (Toxicologic pathology, 2018)
Keywords: Acetylgalactosamine - chemistry; Acetylgalactosamine - pharmacology; Acetylgalactosamine - toxicity; Animals; CHO Cells; Chromosome Aberrations - chemically induced; Cricetulus; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Liver - drug effects; Liver - pathology; Lymphocytes - drug effects; Lymphocytes - pathology; Macaca fascicularis; Mutagenicity Tests; Rats, Sprague-Dawley; RNA, Small Interfering - chemistry; RNA, Small Interfering - genetics; RNA, Small Interfering - pharmacology; RNA, Small Interfering - toxicity; Species Specificity; Toxicity Tests, Subacute; rat pathology; liver; preclinical safety assessment/risk management; drug development; cell(ular) pathology; monkey pathology; preclinical research and development