Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn

• Published in: The Journal of physiology Vol. 548; no. 1; pp. 131 - 138
• Main Authors: Kohno, T., Moore, K. A, Baba, H., Woolf, C. J
• Format: Journal Article
• Language: English
• Published: England The Physiological Society 01.04.2003; Blackwell Science Inc
• Subjects: Action Potentials - physiology; Animals; Constriction, Pathologic - pathology; Electrophysiology; Excitatory Amino Acids - physiology; Excitatory Postsynaptic Potentials - physiology; In Vitro Techniques; Membrane Potentials - physiology; Nerve Fibers, Myelinated - physiology; Neural Conduction - physiology; Neurons, Afferent - physiology; Original; Patch-Clamp Techniques; Peripheral Nerve Injuries; Posterior Horn Cells - physiology; Rats; Sciatic Nerve - injuries; Synapses - physiology; Synaptic Transmission - physiology

Using the blind whole cell patch-clamp recording technique, we investigated peripheral nerve injury-induced changes in excitatory synaptic transmission to neurones in lamina II of the dorsal horn. Partial (i.e. chronic constriction injury (CCI) and spared nerve injury (SNI)) and complete (i.e. sciat...