Neurologic outcomes of the premature lamb in an extrauterine environment for neonatal development
Neurologic injury remains the most important morbidity of prematurity. Those born at the earliest gestational ages can face a lifetime of major disability. Perinatal insults result in developmental delay, cerebral palsy, and other profound permanent neurologic impairments. The EXTracorporeal Environ...
Saved in:
Published in | Journal of pediatric surgery Vol. 55; no. 10; pp. 2115 - 2123 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.10.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Neurologic injury remains the most important morbidity of prematurity. Those born at the earliest gestational ages can face a lifetime of major disability. Perinatal insults result in developmental delay, cerebral palsy, and other profound permanent neurologic impairments. The EXTracorporeal Environment for Neonatal Development (EXTEND) aims to transition premature neonates through this sensitive period, but it's impact on neurologic development requires analysis.
Fetal sheep were maintained in a fluid-filled environment for up to 28 days. Physiologic parameters were measured continuously; tissues were subsequently fixed and preserved for myelin quantification, glial cell staining, and structural assessment via magnetic resonance. Surviving animals were functionally assessed.
No evidence of fetal brain ischemia or white matter tract injury associated with the EXTEND system was detected, and the degree of myelination was regionally appropriate and consistent with age matched controls. No evidence of neurologic injury or immaturity was visible on magnetic resonance; animals that transitioned from the system had no persistent neurologic deficits.
No evidence of major neurologic morbidity was found in animals supported on the EXTEND system, though more work needs to be done in order to verify its safety during critical periods of neurologic development. |
---|---|
AbstractList | BACKGROUND/PURPOSENeurologic injury remains the most important morbidity of prematurity. Those born at the earliest gestational ages can face a lifetime of major disability. Perinatal insults result in developmental delay, cerebral palsy, and other profound permanent neurologic impairments. The EXTracorporeal Environment for Neonatal Development (EXTEND) aims to transition premature neonates through this sensitive period, but it's impact on neurologic development requires analysis. METHODSFetal sheep were maintained in a fluid-filled environment for up to 28 days. Physiologic parameters were measured continuously; tissues were subsequently fixed and preserved for myelin quantification, glial cell staining, and structural assessment via magnetic resonance. Surviving animals were functionally assessed. RESULTSNo evidence of fetal brain ischemia or white matter tract injury associated with the EXTEND system was detected, and the degree of myelination was regionally appropriate and consistent with age matched controls. No evidence of neurologic injury or immaturity was visible on magnetic resonance; animals that transitioned from the system had no persistent neurologic deficits. CONCLUSIONSNo evidence of major neurologic morbidity was found in animals supported on the EXTEND system, though more work needs to be done in order to verify its safety during critical periods of neurologic development. Neurologic injury remains the most important morbidity of prematurity. Those born at the earliest gestational ages can face a lifetime of major disability. Perinatal insults result in developmental delay, cerebral palsy, and other profound permanent neurologic impairments. The EXTracorporeal Environment for Neonatal Development (EXTEND) aims to transition premature neonates through this sensitive period, but it's impact on neurologic development requires analysis. Fetal sheep were maintained in a fluid-filled environment for up to 28 days. Physiologic parameters were measured continuously; tissues were subsequently fixed and preserved for myelin quantification, glial cell staining, and structural assessment via magnetic resonance. Surviving animals were functionally assessed. No evidence of fetal brain ischemia or white matter tract injury associated with the EXTEND system was detected, and the degree of myelination was regionally appropriate and consistent with age matched controls. No evidence of neurologic injury or immaturity was visible on magnetic resonance; animals that transitioned from the system had no persistent neurologic deficits. No evidence of major neurologic morbidity was found in animals supported on the EXTEND system, though more work needs to be done in order to verify its safety during critical periods of neurologic development. |
Author | Rossidis, Avery C. Mejaddam, Ali Y. Baumgarten, Heron Partridge, Emily A. Davey, Marcus G. Flake, Alan W. Kim, Aimee Hornick, Matthew A. Schupper, Alexander J. McGovern, Patrick E. Vossough, Arastoo Young, Kathleen Lawrence, Kendall Didier, Ryne A. Hwang, Grace Peranteau, William H. |
Author_xml | – sequence: 1 givenname: Patrick E. surname: McGovern fullname: McGovern, Patrick E. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 2 givenname: Matthew A. surname: Hornick fullname: Hornick, Matthew A. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 3 givenname: Ali Y. surname: Mejaddam fullname: Mejaddam, Ali Y. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 4 givenname: Kendall surname: Lawrence fullname: Lawrence, Kendall organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 5 givenname: Alexander J. surname: Schupper fullname: Schupper, Alexander J. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 6 givenname: Avery C. surname: Rossidis fullname: Rossidis, Avery C. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 7 givenname: Heron surname: Baumgarten fullname: Baumgarten, Heron organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 8 givenname: Arastoo surname: Vossough fullname: Vossough, Arastoo organization: Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 9 givenname: Ryne A. surname: Didier fullname: Didier, Ryne A. organization: Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 10 givenname: Aimee surname: Kim fullname: Kim, Aimee organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 11 givenname: Emily A. surname: Partridge fullname: Partridge, Emily A. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 12 givenname: Grace surname: Hwang fullname: Hwang, Grace organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 13 givenname: Kathleen surname: Young fullname: Young, Kathleen organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 14 givenname: William H. surname: Peranteau fullname: Peranteau, William H. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 15 givenname: Marcus G. surname: Davey fullname: Davey, Marcus G. organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA – sequence: 16 givenname: Alan W. surname: Flake fullname: Flake, Alan W. email: flake@email.chop.edu organization: The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32014247$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkE9v2zAMxYUiRZv--QqBjrvYpSTLiW8bgm0tUGyX9izIMpUqsCVXkoPt289p2l17IkC-x0f-rsjCB4-ErBiUDFh9ty_3I3ZpiruSA2tKxkvg9RlZMilYIUGsF2QJwHkhqnpzSa5S2gPMbWAX5FLMnopX6yXRv3CKoQ87Z2iYsgkDJhoszS9Ix4iDzlNE2uuhpc5T7Sn-yVFPGaPzSNEfXAx-QJ-pDZF6DF5n3dMOD9iH8Ti4IedW9wlv3-s1ef7x_Wl7Xzz-_vmw_fZYmEpUudAVYFsxrLnYNOvaWGmk5AZaY5qmlhI6i2KtxQagElzbtm4bazUHZJphI8Q1-XLaO8bwOmHKanDJYN_r-aopKS4kNLCRb9L6JDUxpBTRqjG6Qce_ioE64lV79YFXHfEqxtWMdzau3jOmdsDuv-2D5yz4ehLg_OnBYVTJOPQGOxfRZNUF91nGP4vlkwU |
CitedBy_id | crossref_primary_10_1002_jum_15642 crossref_primary_10_1038_s41372_023_01716_2 crossref_primary_10_1016_j_placenta_2022_10_003 crossref_primary_10_5759_jscas_22_180 crossref_primary_10_1177_02676591241240725 crossref_primary_10_1007_s00383_020_04800_2 crossref_primary_10_1016_j_jpedsurg_2021_10_025 crossref_primary_10_1017_S1047951121002894 crossref_primary_10_1080_15265161_2023_2191056 crossref_primary_10_1136_medethics_2021_107892 crossref_primary_10_1016_j_rmclc_2021_10_005 crossref_primary_10_1002_pd_5821 crossref_primary_10_1016_j_siny_2022_101408 crossref_primary_10_1016_j_sempedsurg_2023_151336 crossref_primary_10_3390_biomedicines11030702 crossref_primary_10_1016_j_semperi_2021_151521 |
Cites_doi | 10.1056/NEJMoa1605566 10.1002/14651858.CD012077 10.1007/s13311-012-0108-y 10.1016/S0022-3476(79)80373-X 10.1053/siny.1999.0001 10.1097/WCO.0b013e3282f88bb4 10.1001/jamapediatrics.2017.5323 10.1111/aor.12656 10.1016/j.jpedsurg.2014.10.028 10.1001/jama.2015.10244 10.1016/j.pcl.2009.03.005 10.1113/jphysiol.1972.sp009698 10.1016/j.earlhumdev.2005.03.005 10.1016/j.jpedsurg.2012.10.030 10.1056/NEJMoa1403489 10.1136/fn.72.1.F62 10.1203/00006450-199802000-00018 10.1016/S0140-6736(12)60560-1 10.1016/j.jns.2004.10.006 10.1007/s10198-016-0850-x 10.1113/jphysiol.1955.sp005403 10.1016/0378-3782(79)90005-7 10.1002/cne.901350302 10.1055/s-2007-994787 10.1038/nature12647 10.1016/S0140-6736(08)60074-4 10.1113/jphysiol.1980.sp013227 |
ContentType | Journal Article |
Copyright | 2020 Elsevier Inc. Copyright © 2020 Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2020 Elsevier Inc. – notice: Copyright © 2020 Elsevier Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.jpedsurg.2019.12.026 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1531-5037 |
EndPage | 2123 |
ExternalDocumentID | 10_1016_j_jpedsurg_2019_12_026 32014247 S0022346819309364 |
Genre | Journal Article |
GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 3O- 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AAXUO ABBQC ABFNM ABFRF ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABPPZ ABXDB ABYKQ ACDAQ ACGFO ACGFS ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG COF CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEF HMK HMO HVGLF HZ~ IHE J1W K-O KOM L7B LCYCR M29 M32 M41 MO0 N4W N9A O-L O9- OAUVE OK- OW- OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SDF SDG SDP SEL SES SEW SJN SPCBC SSH SSZ T5K UGJ UHS UV1 WUQ X7M Z5R ZA5 ZGI ~G- AAQOH AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX ACRPL ADNMO CITATION 7X8 |
ID | FETCH-LOGICAL-c434t-a40eb41e6238976cf5c552c0bcc996550dfe37a3800432afb6b9ffa20e1a1e933 |
IEDL.DBID | AIKHN |
ISSN | 0022-3468 |
IngestDate | Wed Dec 04 00:59:17 EST 2024 Fri Dec 06 02:32:02 EST 2024 Sat Sep 28 08:24:59 EDT 2024 Fri Feb 23 02:47:33 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Keywords | Prematurity Preterm birth Neurologic injury |
Language | English |
License | Copyright © 2020 Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c434t-a40eb41e6238976cf5c552c0bcc996550dfe37a3800432afb6b9ffa20e1a1e933 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 32014247 |
PQID | 2350908593 |
PQPubID | 23479 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_2350908593 crossref_primary_10_1016_j_jpedsurg_2019_12_026 pubmed_primary_32014247 elsevier_sciencedirect_doi_10_1016_j_jpedsurg_2019_12_026 |
PublicationCentury | 2000 |
PublicationDate | October 2020 2020-Oct 2020-10-00 20201001 |
PublicationDateYYYYMMDD | 2020-10-01 |
PublicationDate_xml | – month: 10 year: 2020 text: October 2020 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of pediatric surgery |
PublicationTitleAlternate | J Pediatr Surg |
PublicationYear | 2020 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Partridge, Davey, Hornick (bb0080) 2017; 8 Arbeille, Bosc, Vaillant (bb0100) 1992; 9 Younge, Goldstein, Bann (bb0030) 2017; 376 Hack, Fanaroff (bb0025) 2000; 5 Miura, Matsuda, Usuda (bb0125) 2016; 40 Mallard, Rees, Stringer (bb0095) 1998; 43 Reynolds, Evans, Reynolds (bb0160) 1979; 3 Jacob, Lehne, Mischker (bb0050) 2017; 18 Liu, Johnson, Cousens (bb0005) 2012; 379 Patel, Kandefer, Walsh (bb0010) 2015; 372 Butler, Behrman (bb0045) 2007 Chapman, Dawes, Rurak (bb0110) 1980; 302 Gray, El-Sabbagh, Zakem (bb0115) 2013; 48 Kinney (bb0060) 2005; 228 Shepherd, Middleton, Makrides (bb0070) 2016; 10 Greisen (bb0135) 2005; 81 Born, Dawes, Mott (bb0140) 1955; 130 Bryner, Gray, Perkins (bb0120) 2015; 50 Goldenberg, Culhane, Iams (bb0075) 2008; 371 Dawes, Fox, Leduc (bb0105) 1972; 220 Back, Riddle, Dean (bb0155) 2012; 9 Lucas, Stoll, Bale (bb0015) 2003 Stoll, Hansen, Bell (bb0040) 2015; 314 Martin, Barkovich (bb0150) 1995; 72 Prophet (bb0085) 1992 Twilhaar, Wade, de Kieviet (bb0035) 2018; 172 Stephens, Vohr (bb0020) 2009; 56 Barlow (bb0145) 1969; 135 Lou, Lassen, Friis-Hansen (bb0130) 1979; 94 Shepherd, Middleton, Makrides (bb0065) 2016; 2 Deshmukh, Tardif, Lyssiotis (bb0090) 2013; 502 Allen (bb0055) 2008; 21 Miura (10.1016/j.jpedsurg.2019.12.026_bb0125) 2016; 40 Jacob (10.1016/j.jpedsurg.2019.12.026_bb0050) 2017; 18 Lucas (10.1016/j.jpedsurg.2019.12.026_bb0015) 2003 Goldenberg (10.1016/j.jpedsurg.2019.12.026_bb0075) 2008; 371 Greisen (10.1016/j.jpedsurg.2019.12.026_bb0135) 2005; 81 Liu (10.1016/j.jpedsurg.2019.12.026_bb0005) 2012; 379 Twilhaar (10.1016/j.jpedsurg.2019.12.026_bb0035) 2018; 172 Prophet (10.1016/j.jpedsurg.2019.12.026_bb0085) 1992 Hack (10.1016/j.jpedsurg.2019.12.026_bb0025) 2000; 5 Chapman (10.1016/j.jpedsurg.2019.12.026_bb0110) 1980; 302 Bryner (10.1016/j.jpedsurg.2019.12.026_bb0120) 2015; 50 Arbeille (10.1016/j.jpedsurg.2019.12.026_bb0100) 1992; 9 Partridge (10.1016/j.jpedsurg.2019.12.026_bb0080) 2017; 8 Kinney (10.1016/j.jpedsurg.2019.12.026_bb0060) 2005; 228 Shepherd (10.1016/j.jpedsurg.2019.12.026_bb0070) 2016; 10 Dawes (10.1016/j.jpedsurg.2019.12.026_bb0105) 1972; 220 Back (10.1016/j.jpedsurg.2019.12.026_bb0155) 2012; 9 Stephens (10.1016/j.jpedsurg.2019.12.026_bb0020) 2009; 56 Butler (10.1016/j.jpedsurg.2019.12.026_bb0045) 2007 Barlow (10.1016/j.jpedsurg.2019.12.026_bb0145) 1969; 135 Born (10.1016/j.jpedsurg.2019.12.026_bb0140) 1955; 130 Martin (10.1016/j.jpedsurg.2019.12.026_bb0150) 1995; 72 Lou (10.1016/j.jpedsurg.2019.12.026_bb0130) 1979; 94 Younge (10.1016/j.jpedsurg.2019.12.026_bb0030) 2017; 376 Shepherd (10.1016/j.jpedsurg.2019.12.026_bb0065) 2016; 2 Patel (10.1016/j.jpedsurg.2019.12.026_bb0010) 2015; 372 Allen (10.1016/j.jpedsurg.2019.12.026_bb0055) 2008; 21 Stoll (10.1016/j.jpedsurg.2019.12.026_bb0040) 2015; 314 Deshmukh (10.1016/j.jpedsurg.2019.12.026_bb0090) 2013; 502 Gray (10.1016/j.jpedsurg.2019.12.026_bb0115) 2013; 48 Mallard (10.1016/j.jpedsurg.2019.12.026_bb0095) 1998; 43 Reynolds (10.1016/j.jpedsurg.2019.12.026_bb0160) 1979; 3 |
References_xml | – volume: 502 start-page: 327 year: 2013 ident: bb0090 article-title: A regenerative approach to the treatment of multiple sclerosis publication-title: Nature contributor: fullname: Lyssiotis – volume: 9 start-page: 359 year: 2012 end-page: 370 ident: bb0155 article-title: The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant publication-title: Neurotherapeutics contributor: fullname: Dean – volume: 379 start-page: 2151 year: 2012 end-page: 2161 ident: bb0005 article-title: Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000 publication-title: The Lancet contributor: fullname: Cousens – volume: 9 start-page: 270 year: 1992 end-page: 274 ident: bb0100 article-title: nicotine-induced changes in the cerebral circulation in ovine fetuses publication-title: Amer J Perinatol contributor: fullname: Vaillant – volume: 3 start-page: 163 year: 1979 end-page: 185 ident: bb0160 article-title: Intracranial haemorrhage in the preterm sheep fetus publication-title: Early Hum Dev contributor: fullname: Reynolds – volume: 2 year: 2016 ident: bb0065 article-title: Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews publication-title: Cochrane Database Syst Rev contributor: fullname: Makrides – volume: 72 start-page: F62 year: 1995 end-page: F70 ident: bb0150 article-title: Magnetic resonance imaging in perinatal asphyxia publication-title: Arch Dis Child Fetal Neonatal Ed contributor: fullname: Barkovich – volume: 43 start-page: 262 year: 1998 end-page: 270 ident: bb0095 article-title: Effects of chronic placental insufficiency on brain development in fetal sheep publication-title: Pediatr Res contributor: fullname: Stringer – volume: 81 start-page: 423 year: 2005 end-page: 428 ident: bb0135 article-title: Autoregulation of cerebral blood flow in newborn babies publication-title: Early Hum Dev contributor: fullname: Greisen – year: 2003 ident: bb0015 article-title: Improving birth outcomes: Meeting the challenge in the developing world contributor: fullname: Bale – volume: 21 start-page: 123 year: 2008 end-page: 128 ident: bb0055 article-title: Neurodevelopmental outcomes of preterm infants publication-title: Curr Opin Neurol contributor: fullname: Allen – volume: 220 start-page: 119 year: 1972 end-page: 143 ident: bb0105 article-title: Respiratory movements and rapid eye movement sleep in the foetal lamb publication-title: J Physiol contributor: fullname: Leduc – volume: 56 start-page: 631 year: 2009 end-page: 646 ident: bb0020 article-title: Neurodevelopmental outcome of the premature infant publication-title: Pediatr Clin North Am contributor: fullname: Vohr – volume: 228 start-page: 190 year: 2005 end-page: 192 ident: bb0060 article-title: Human myelination and perinatal white matter disorders publication-title: J Neurol Sci contributor: fullname: Kinney – volume: 10 year: 2016 ident: bb0070 article-title: Neonatal interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews publication-title: Cochrane Database Syst Rev contributor: fullname: Makrides – volume: 376 start-page: 617 year: 2017 end-page: 628 ident: bb0030 article-title: Survival and neurodevelopmental outcomes among periviable infants publication-title: New England Journal of Medicine contributor: fullname: Bann – volume: 172 start-page: 361 year: 2018 end-page: 367 ident: bb0035 article-title: Cognitive outcomes of children born extremely or very preterm since the 1990s and associated risk factors: a meta-analysis and meta-regression publication-title: JAMA Pediatr contributor: fullname: de Kieviet – volume: 302 start-page: 19 year: 1980 end-page: 29 ident: bb0110 article-title: Breathing movements in fetal lambs and the effect of hypercapnia publication-title: J Physiol contributor: fullname: Rurak – year: 2007 ident: bb0045 article-title: Preterm birth: Causes, consequences, and prevention contributor: fullname: Behrman – volume: 8 year: 2017 ident: bb0080 article-title: An extra-uterine system to physiologically support the extreme premature lamb publication-title: Nat Commun contributor: fullname: Hornick – volume: 40 start-page: E61-E8 year: 2016 ident: bb0125 article-title: A parallelized pumpless artificial placenta system significantly prolonged survival time in a preterm lamb model publication-title: Artif Organs contributor: fullname: Usuda – volume: 50 start-page: 44 year: 2015 end-page: 49 ident: bb0120 article-title: An extracorporeal artificial placenta supports extremely premature lambs for 1week publication-title: J Pediatr Surg contributor: fullname: Perkins – volume: 135 start-page: 249 year: 1969 end-page: 261 ident: bb0145 article-title: The foetal sheep: morphogenesis of the nervous system and histochemical aspects of myelination publication-title: J Comp Neurol contributor: fullname: Barlow – volume: 5 start-page: 89 year: 2000 end-page: 106 ident: bb0025 article-title: Outcomes of children of extremely low birthweight and gestational age in the 1990s publication-title: Semin Neonatol contributor: fullname: Fanaroff – year: 1992 ident: bb0085 article-title: Armed forces Institute of P. laboratory methods in histotechnology contributor: fullname: Prophet – volume: 48 start-page: 145 year: 2013 end-page: 153 ident: bb0115 article-title: Development of an artificial placenta V: 70h veno-venous extracorporeal life support after ventilatory failure in premature lambs publication-title: J Pediatr Surg contributor: fullname: Zakem – volume: 94 start-page: 118 year: 1979 end-page: 121 ident: bb0130 article-title: Impaired autoregulation of cerebral blood flow in the distressed newborn infant publication-title: J Pediatr contributor: fullname: Friis-Hansen – volume: 372 start-page: 331 year: 2015 end-page: 340 ident: bb0010 article-title: Causes and timing of death in extremely premature infants from 2000 through 2011 publication-title: New England Journal of Medicine contributor: fullname: Walsh – volume: 130 start-page: 191 year: 1955 end-page: 212 ident: bb0140 article-title: The viability of premature lambs publication-title: J Physiol contributor: fullname: Mott – volume: 314 start-page: 1039 year: 2015 end-page: 1051 ident: bb0040 article-title: Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012 publication-title: JAMA contributor: fullname: Bell – volume: 371 start-page: 75 year: 2008 end-page: 84 ident: bb0075 article-title: Epidemiology and causes of preterm birth publication-title: The Lancet contributor: fullname: Iams – volume: 18 start-page: 1041 year: 2017 end-page: 1046 ident: bb0050 article-title: Cost effects of preterm birth: a comparison of health care costs associated with early preterm, late preterm, and full-term birth in the first 3 years after birth publication-title: Eur J Health Econ contributor: fullname: Mischker – volume: 376 start-page: 617 issue: 7 year: 2017 ident: 10.1016/j.jpedsurg.2019.12.026_bb0030 article-title: Survival and neurodevelopmental outcomes among periviable infants publication-title: New England Journal of Medicine doi: 10.1056/NEJMoa1605566 contributor: fullname: Younge – volume: 2 year: 2016 ident: 10.1016/j.jpedsurg.2019.12.026_bb0065 article-title: Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD012077 contributor: fullname: Shepherd – volume: 9 start-page: 359 issue: 2 year: 2012 ident: 10.1016/j.jpedsurg.2019.12.026_bb0155 article-title: The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant publication-title: Neurotherapeutics doi: 10.1007/s13311-012-0108-y contributor: fullname: Back – volume: 94 start-page: 118 issue: 1 year: 1979 ident: 10.1016/j.jpedsurg.2019.12.026_bb0130 article-title: Impaired autoregulation of cerebral blood flow in the distressed newborn infant publication-title: J Pediatr doi: 10.1016/S0022-3476(79)80373-X contributor: fullname: Lou – volume: 5 start-page: 89 issue: 2 year: 2000 ident: 10.1016/j.jpedsurg.2019.12.026_bb0025 article-title: Outcomes of children of extremely low birthweight and gestational age in the 1990s publication-title: Semin Neonatol doi: 10.1053/siny.1999.0001 contributor: fullname: Hack – volume: 21 start-page: 123 issue: 2 year: 2008 ident: 10.1016/j.jpedsurg.2019.12.026_bb0055 article-title: Neurodevelopmental outcomes of preterm infants publication-title: Curr Opin Neurol doi: 10.1097/WCO.0b013e3282f88bb4 contributor: fullname: Allen – volume: 10 year: 2016 ident: 10.1016/j.jpedsurg.2019.12.026_bb0070 article-title: Neonatal interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD012077 contributor: fullname: Shepherd – volume: 172 start-page: 361 issue: 4 year: 2018 ident: 10.1016/j.jpedsurg.2019.12.026_bb0035 article-title: Cognitive outcomes of children born extremely or very preterm since the 1990s and associated risk factors: a meta-analysis and meta-regression publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2017.5323 contributor: fullname: Twilhaar – volume: 40 start-page: E61-E8 issue: 5 year: 2016 ident: 10.1016/j.jpedsurg.2019.12.026_bb0125 article-title: A parallelized pumpless artificial placenta system significantly prolonged survival time in a preterm lamb model publication-title: Artif Organs doi: 10.1111/aor.12656 contributor: fullname: Miura – volume: 50 start-page: 44 issue: 1 year: 2015 ident: 10.1016/j.jpedsurg.2019.12.026_bb0120 article-title: An extracorporeal artificial placenta supports extremely premature lambs for 1week publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2014.10.028 contributor: fullname: Bryner – volume: 314 start-page: 1039 issue: 10 year: 2015 ident: 10.1016/j.jpedsurg.2019.12.026_bb0040 article-title: Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012 publication-title: JAMA doi: 10.1001/jama.2015.10244 contributor: fullname: Stoll – volume: 56 start-page: 631 issue: 3 year: 2009 ident: 10.1016/j.jpedsurg.2019.12.026_bb0020 article-title: Neurodevelopmental outcome of the premature infant publication-title: Pediatr Clin North Am doi: 10.1016/j.pcl.2009.03.005 contributor: fullname: Stephens – volume: 220 start-page: 119 issue: 1 year: 1972 ident: 10.1016/j.jpedsurg.2019.12.026_bb0105 article-title: Respiratory movements and rapid eye movement sleep in the foetal lamb publication-title: J Physiol doi: 10.1113/jphysiol.1972.sp009698 contributor: fullname: Dawes – volume: 81 start-page: 423 issue: 5 year: 2005 ident: 10.1016/j.jpedsurg.2019.12.026_bb0135 article-title: Autoregulation of cerebral blood flow in newborn babies publication-title: Early Hum Dev doi: 10.1016/j.earlhumdev.2005.03.005 contributor: fullname: Greisen – volume: 48 start-page: 145 issue: 1 year: 2013 ident: 10.1016/j.jpedsurg.2019.12.026_bb0115 article-title: Development of an artificial placenta V: 70h veno-venous extracorporeal life support after ventilatory failure in premature lambs publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2012.10.030 contributor: fullname: Gray – volume: 372 start-page: 331 issue: 4 year: 2015 ident: 10.1016/j.jpedsurg.2019.12.026_bb0010 article-title: Causes and timing of death in extremely premature infants from 2000 through 2011 publication-title: New England Journal of Medicine doi: 10.1056/NEJMoa1403489 contributor: fullname: Patel – volume: 72 start-page: F62 issue: 1 year: 1995 ident: 10.1016/j.jpedsurg.2019.12.026_bb0150 article-title: Magnetic resonance imaging in perinatal asphyxia publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/fn.72.1.F62 contributor: fullname: Martin – volume: 43 start-page: 262 issue: 2 year: 1998 ident: 10.1016/j.jpedsurg.2019.12.026_bb0095 article-title: Effects of chronic placental insufficiency on brain development in fetal sheep publication-title: Pediatr Res doi: 10.1203/00006450-199802000-00018 contributor: fullname: Mallard – volume: 379 start-page: 2151 issue: 9832 year: 2012 ident: 10.1016/j.jpedsurg.2019.12.026_bb0005 article-title: Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000 publication-title: The Lancet doi: 10.1016/S0140-6736(12)60560-1 contributor: fullname: Liu – volume: 228 start-page: 190 issue: 2 year: 2005 ident: 10.1016/j.jpedsurg.2019.12.026_bb0060 article-title: Human myelination and perinatal white matter disorders publication-title: J Neurol Sci doi: 10.1016/j.jns.2004.10.006 contributor: fullname: Kinney – volume: 18 start-page: 1041 issue: 8 year: 2017 ident: 10.1016/j.jpedsurg.2019.12.026_bb0050 article-title: Cost effects of preterm birth: a comparison of health care costs associated with early preterm, late preterm, and full-term birth in the first 3 years after birth publication-title: Eur J Health Econ doi: 10.1007/s10198-016-0850-x contributor: fullname: Jacob – volume: 8 year: 2017 ident: 10.1016/j.jpedsurg.2019.12.026_bb0080 article-title: An extra-uterine system to physiologically support the extreme premature lamb publication-title: Nat Commun contributor: fullname: Partridge – volume: 130 start-page: 191 issue: 1 year: 1955 ident: 10.1016/j.jpedsurg.2019.12.026_bb0140 article-title: The viability of premature lambs publication-title: J Physiol doi: 10.1113/jphysiol.1955.sp005403 contributor: fullname: Born – year: 1992 ident: 10.1016/j.jpedsurg.2019.12.026_bb0085 contributor: fullname: Prophet – year: 2007 ident: 10.1016/j.jpedsurg.2019.12.026_bb0045 contributor: fullname: Butler – volume: 3 start-page: 163 issue: 2 year: 1979 ident: 10.1016/j.jpedsurg.2019.12.026_bb0160 article-title: Intracranial haemorrhage in the preterm sheep fetus publication-title: Early Hum Dev doi: 10.1016/0378-3782(79)90005-7 contributor: fullname: Reynolds – volume: 135 start-page: 249 issue: 3 year: 1969 ident: 10.1016/j.jpedsurg.2019.12.026_bb0145 article-title: The foetal sheep: morphogenesis of the nervous system and histochemical aspects of myelination publication-title: J Comp Neurol doi: 10.1002/cne.901350302 contributor: fullname: Barlow – year: 2003 ident: 10.1016/j.jpedsurg.2019.12.026_bb0015 contributor: fullname: Lucas – volume: 9 start-page: 270 issue: 04 year: 1992 ident: 10.1016/j.jpedsurg.2019.12.026_bb0100 article-title: nicotine-induced changes in the cerebral circulation in ovine fetuses publication-title: Amer J Perinatol doi: 10.1055/s-2007-994787 contributor: fullname: Arbeille – volume: 502 start-page: 327 issue: 7471 year: 2013 ident: 10.1016/j.jpedsurg.2019.12.026_bb0090 article-title: A regenerative approach to the treatment of multiple sclerosis publication-title: Nature doi: 10.1038/nature12647 contributor: fullname: Deshmukh – volume: 371 start-page: 75 issue: 9606 year: 2008 ident: 10.1016/j.jpedsurg.2019.12.026_bb0075 article-title: Epidemiology and causes of preterm birth publication-title: The Lancet doi: 10.1016/S0140-6736(08)60074-4 contributor: fullname: Goldenberg – volume: 302 start-page: 19 year: 1980 ident: 10.1016/j.jpedsurg.2019.12.026_bb0110 article-title: Breathing movements in fetal lambs and the effect of hypercapnia publication-title: J Physiol doi: 10.1113/jphysiol.1980.sp013227 contributor: fullname: Chapman |
SSID | ssj0003701 |
Score | 2.4526296 |
Snippet | Neurologic injury remains the most important morbidity of prematurity. Those born at the earliest gestational ages can face a lifetime of major disability.... BACKGROUND/PURPOSENeurologic injury remains the most important morbidity of prematurity. Those born at the earliest gestational ages can face a lifetime of... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 2115 |
SubjectTerms | Animals Animals, Newborn Brain - diagnostic imaging Brain - physiology Fetus - physiology Intensive Care, Neonatal - methods Magnetic Resonance Imaging Myelin Sheath - chemistry Myelin Sheath - physiology Neurologic injury Premature Birth - therapy Prematurity Preterm birth Sheep Sheep, Domestic |
Title | Neurologic outcomes of the premature lamb in an extrauterine environment for neonatal development |
URI | https://dx.doi.org/10.1016/j.jpedsurg.2019.12.026 https://www.ncbi.nlm.nih.gov/pubmed/32014247 https://search.proquest.com/docview/2350908593 |
Volume | 55 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB6qgngR39ZHWcFrbLOPpDmKWKpFD2Kxt2WT7Ep7SEuaXP3tzm6SWkHxIIQEAptsZjbfzOzMfgtwnWo_ocpQj4tQ4SkIvBitBipEKyNEyBLtqi2eg-GYP07EpAV3zVoYW1ZZY3-F6Q6t6zvdWprdxXRq1_iiaeMBmjSbzQv4BmyhObK52q3bh9HweQXILOz5K9JwbLC2UHh2M1vodFnm77bKK3Izg5Zn4Wcb9ZsP6mzRYA92ayeS3Fb93IeWzg5g-6lOkx-CcpQbDtXIvCzw2_SSzA1BZ48scsvSWuaa4FiIyTQjKiOI0Lmymztgc7K29o2gS0sybWfY8X3pV4HREYwH9693Q6_eS8FLOOOFp3hPx9zX6O300QNJjEiEoEkvThKMeDBMSY1moWJ9x9GnTBzEkTEKVeYrX0eMHcNmNs_0KZBU0KgvlK-45nhgNE6p5Z2LMXRDSDBt6DbSk4uKMkM2tWQz2chbWnlLn0qUdxuiRsjym_Il4vqfba8arUj8M2y6Q6FcyqWkDJ0hx-fWhpNKXav-MHwCpzw8-8ebz2GH2uDbVfZdwGaRl_oSPZQi7sDGzYffqcehvY5e3kafAKzoGw |
link.rule.ids | 314,780,784,4502,24116,27924,27925,45585,45679 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwED5BkYAF8aY8jcSatvEjaUZUUZVXpyKxWU5io3ZIqzRZ-e2cnYSCBGJAijJEceLcOXff2XefAW5S7SdUGepxESo8BYEXo9dAhWhlhAhZol22xTgYvfCHV_G6BoOmFsamVda2v7LpzlrXV7q1NLuL6dTW-KJr4wG6NLuaF_B12OAC0S8O6s77Ks-DhT3_kzIcb_9SJjzrzBY6XZb5m83xity8oGVZ-NlD_YZAnSca7sJODSHJbdXLPVjT2T5sPteL5AegHOGGs2lkXhb4ZXpJ5oYg1COL3HK0lrkmOBJiMs2Iygja51zZrR2wOflS-UYQ0JJM2_l1fF-6Si86hJfh3WQw8uqdFLyEM154ivd0zH2NWKeP-CMxIhGCJr04STDewSAlNZqFivUdQ58ycRBHxihUmK98HTF2BK1snukTIKmgUV8oX3HN8cBYnFLLOhdj4IYGwbSh20hPLirCDNlkks1kI29p5S19KlHebYgaIctvqpdo1f9se91oReJ_YRc7FMqlXErKEAo5Nrc2HFfq-uwPwydwysPTf7z5CrZGk-cn-XQ_fjyDbWrDcJfjdw6tIi_1BWKVIr50Y_ED3tznUQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neurologic+outcomes+of+the+premature+lamb+in+an+extrauterine+environment+for+neonatal+development&rft.jtitle=Journal+of+pediatric+surgery&rft.au=McGovern%2C+Patrick+E&rft.au=Hornick%2C+Matthew+A&rft.au=Mejaddam%2C+Ali+Y&rft.au=Lawrence%2C+Kendall&rft.date=2020-10-01&rft.eissn=1531-5037&rft.volume=55&rft.issue=10&rft.spage=2115&rft_id=info:doi/10.1016%2Fj.jpedsurg.2019.12.026&rft_id=info%3Apmid%2F32014247&rft.externalDocID=32014247 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3468&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3468&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3468&client=summon |