Kcnma1 alternative splicing in mouse kidney: regulation during development and by dietary K + intake

• Published in: American journal of physiology. Renal physiology Vol. 327; no. 1; pp. F49 - F60
• Main Authors: Whelan, Sarah Christine M., Mutchler, Stephanie M., Han, Agnes, Priestley, Catherine, Satlin, Lisa M., Kleyman, Thomas R., Shi, Shujie
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2024
• Subjects: Alternative Splicing; Animals; Dietary intake; Distal tubules; Exons; Female; Gene Expression Regulation, Developmental; Homeostasis; Kidney - metabolism; Kidneys; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism; Male; Mice; Mice, Inbred C57BL; Phenotypic variations; Potassium channels (calcium-gated); Potassium conductance; Potassium, Dietary - metabolism; BK channel; splice variants; kidney; potassium; Kcnma1

We identified the major Kcnma1 splice variants that are specifically expressed in the whole mouse kidney or aldosterone-sensitive distal nephron segments. Our data suggest that Kcnma1 alternative splicing is developmentally regulated and subject to changes in dietary K + . The pore-forming α-subunit...