Robust spike timing in an excitable cell with delayed feedback

• Published in: Journal of the Royal Society interface Vol. 18; no. 177; p. 20210029
• Main Authors: Wedgwood, Kyle C. A., Słowiński, Piotr, Manson, James, Tsaneva-Atanasova, Krasimira, Krauskopf, Bernd
• Format: Journal Article
• Language: English
• Published: England The Royal Society 01.04.2021
• Subjects: Animals; Feedback; Life Sciences–Mathematics interface; Models, Theoretical; Neurons; mathematical modelling; delayed feedback; dynamic clamp; neuronal excitability

The initiation and regeneration of pulsatile activity is a ubiquitous feature observed in excitable systems with delayed feedback. Here, we demonstrate this phenomenon in a real biological cell. We establish a critical role of the delay resulting from the finite propagation speed of electrical impul...