Robust spike timing in an excitable cell with delayed feedback

The initiation and regeneration of pulsatile activity is a ubiquitous feature observed in excitable systems with delayed feedback. Here, we demonstrate this phenomenon in a real biological cell. We establish a critical role of the delay resulting from the finite propagation speed of electrical impul...

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Bibliographic Details
Published inJournal of the Royal Society interface Vol. 18; no. 177; p. 20210029
Main Authors Wedgwood, Kyle C. A., Słowiński, Piotr, Manson, James, Tsaneva-Atanasova, Krasimira, Krauskopf, Bernd
Format Journal Article
LanguageEnglish
Published England The Royal Society 01.04.2021
Subjects
Animals
Feedback
Life Sciences–Mathematics interface
Models, Theoretical
Neurons
mathematical modelling
delayed feedback
dynamic clamp
neuronal excitability
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Summary:The initiation and regeneration of pulsatile activity is a ubiquitous feature observed in excitable systems with delayed feedback. Here, we demonstrate this phenomenon in a real biological cell. We establish a critical role of the delay resulting from the finite propagation speed of electrical impulses in the emergence of persistent multiple-spike patterns. We predict the coexistence of a number of such patterns in a mathematical model and use a biological cell subject to dynamic clamp to confirm our predictions in a living mammalian system. Given the general nature of our mathematical model and experimental system, we believe that our results capture key hallmarks of physiological excitability that are fundamental to information processing.
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Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5359395.
These authors contributed equally to the study.
ISSN:1742-5662
1742-5689
1742-5662
DOI:10.1098/rsif.2021.0029