Microwave-assisted synthesis of new 2-aryl and 2-alkylimidazolones and evaluation of their in vitro anticancer activity and their in vivo toxicity on zebrafish embryos

• Published in: Chemical papers Vol. 75; no. 6; pp. 2549 - 2560
• Main Authors: Bou Zeid, Samar, Hamade, Aline, Najjar, Fadia, Carreaux, Francois, Eid, Samar
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2021; Springer Nature B.V; Versita (Central European Science Journals)
• Subjects: Abnormalities; Anticancer properties; Aromatic compounds; Biochemistry; Biocompatibility; Biotechnology; Cancer; Chemical Sciences; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Cytotoxicity; Doxorubicin; Embryos; Industrial Chemistry/Chemical Engineering; Materials Science; Medicinal Chemistry; Original Paper; Synthesis; Toxicity; Zebrafish; One-pot synthesis; Zebrafish embryos; Imidazolone derivatives; Microwave irradiations; Anticancer activity

Herein we describe the synthesis of five new 2-aryl and 2-alkylimidazolone derivatives via an effective one-pot synthetic strategy assisted by microwave irradiations which allowed us to access the desired product in a reduced time reaction compared to the thermal heating and a slightly better yield...