Structural and physiological neurovascular changes in idiopathic Parkinson’s disease and its clinical phenotypes

• Published in: Journal of cerebral blood flow and metabolism Vol. 37; no. 10; pp. 3409 - 3421
• Main Authors: Al-Bachari, Sarah, Vidyasagar, Rishma, Emsley, Hedley CA, Parkes, Laura M
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2017
• Subjects: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders - diagnostic imaging; Female; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Neurovascular Coupling; Original; Parkinson Disease - diagnostic imaging; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Phenotype; Spin Labels; White Matter - pathology; arterial spin labelling; cerebral blood flow; cerebrovascular disease; Magnetic resonance imaging; Parkinson’s disease

Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson’s disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial...