Differential roles of two DDX17 isoforms in the formation of membraneless organelles

• Published in: Journal of biochemistry (Tokyo) Vol. 168; no. 1; pp. 33 - 40
• Main Authors: Hirai, Yuya, Domae, Eisuke, Yoshikawa, Yoshihiro, Tomonaga, Keizo
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2020
• Subjects: Cell Nucleolus - metabolism; Cell Nucleus - metabolism; DEAD-box RNA Helicases - metabolism; Female; HeLa Cells; Humans; Organelles - metabolism; Protein Isoforms; RNA - metabolism; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; DDX17; nucleolus; stress granules; membraneless organelles; intrinsically disordered regions

Abstract The RNA helicase, DDX17 is a member of the DEAD-box protein family. DDX17 has two isoforms: p72 and p82. The p82 isoform has additional amino acid sequences called intrinsically disordered regions (IDRs), which are related to the formation of membraneless organelles (MLOs). Here, we reveal...