Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

• Published in: Carcinogenesis (New York) Vol. 13; no. 7; p. 1143
• Main Authors: Csanády, G A, Guengerich, F P, Bond, J A
• Format: Journal Article
• Language: English
• Published: England 01.07.1992
• Subjects: Animals; Biotransformation; Butadienes - metabolism; Butadienes - pharmacokinetics; Carcinogens - metabolism; Cytosol - metabolism; Epoxy Compounds - metabolism; Epoxy Compounds - pharmacokinetics; Humans; Kinetics; Liver - metabolism; Lung - metabolism; Male; Mathematics; Mice; Mice, Inbred Strains; Microsomes - metabolism; Microsomes, Liver - metabolism; Models, Biological; Organ Specificity; Rats; Rats, Inbred Strains; Species Specificity

1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptib...