ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

• Published in: eLife Vol. 12
• Main Authors: Menon, Debashish U, Chakraborty, Prabuddha, Murcia, Noel, Magnuson, Terry
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 26.11.2024; eLife Sciences Publications, Ltd
• Subjects: Animals; ARID1A; BRG1 protein; Cell death; Cell division; Chromatids; Chromatin; chromatin remodelers; Developmental Biology; DNA damage; DNA repair; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; DNA-directed RNA polymerase; Gene regulation; Gene Silencing; Genetics and Genomics; Germ cells; Histones; Histones - genetics; Histones - metabolism; Immunofluorescence; Localization; Male; Males; Meiosis; Meiosis - genetics; meiotic sex chromosome; Mice; Mouse; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Proteins; Recombinase; RNA polymerase; Sex chromosomes; Sex Chromosomes - genetics; Sex linkage; Somatic chromosomes; Spermatogenesis; Testes; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; genetics; Mouse; meiotic sex chromosome; gene regulation; sex-linked DNA repair; developmental biology; spermatogenesis; genomics; ARID1A; chromatin remodelers

We present evidence implicating the BAF (BRG1/BRM Associated Factor) chromatin remodeler in meiotic sex chromosome inactivation (MSCI). By immunofluorescence (IF), the putative BAF DNA binding subunit, ARID1A (AT-rich Interaction Domain 1 a), appeared enriched on the male sex chromosomes during dipl...