Inhibitory Actions of HERG Currents by the Immunosuppressant Drug Cyclosporin A
The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC(50) val...
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| Published in | The Korean journal of physiology & pharmacology Vol. 15; no. 5; pp. 291 - 297 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Physiological Society and The Korean Society of Pharmacology
01.10.2011
대한약리학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-4512 2093-3827 |
| DOI | 10.4196/kjpp.2011.15.5.291 |
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| Abstract | The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC(50) value and a Hill coefficient of 3.17 µM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The CsA-induced inhibition of HERG channels was voltage-dependent, with a steep increase over the voltage range of the channel opening. However, the inhibition exhibited voltage independence over the voltage range of fully activated channels. CsA blocked the HERG channels predominantly in the open and inactivated states rather than in the closed state. Results of the present study suggest that CsA acts directly on the HERG channel as an open-channel blocker, and it acts independently of its effect on calcineurin activity. |
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| AbstractList | The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC(50) value and a Hill coefficient of 3.17 µM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The CsA-induced inhibition of HERG channels was voltage-dependent, with a steep increase over the voltage range of the channel opening. However, the inhibition exhibited voltage independence over the voltage range of fully activated channels. CsA blocked the HERG channels predominantly in the open and inactivated states rather than in the closed state. Results of the present study suggest that CsA acts directly on the HERG channel as an open-channel blocker, and it acts independently of its effect on calcineurin activity. The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC50 value and a Hill coefficient of 3.17μM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The CsA-induced inhibition of HERG channels was voltage-dependent, with a steep increase over the voltage range of the channel opening. However, the inhibition exhibited voltage independence over the voltage range of fully activated channels. CsA blocked the HERG channels predominantly in the open and inactivated states rather than in the closed state. Results of the present study suggest that CsA acts directly on the HERG channel as an open-channel blocker, and it acts independently of its effect on calcineurin activity. KCI Citation Count: 2 The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC 50 value and a Hill coefficient of 3.17 µM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The CsA-induced inhibition of HERG channels was voltage-dependent, with a steep increase over the voltage range of the channel opening. However, the inhibition exhibited voltage independence over the voltage range of fully activated channels. CsA blocked the HERG channels predominantly in the open and inactivated states rather than in the closed state. Results of the present study suggest that CsA acts directly on the HERG channel as an open-channel blocker, and it acts independently of its effect on calcineurin activity. |
| Author | Kim, Jimok Choi, Bok Hee Lee, Seung Ho Min, Gyesik Jo, Su-Hyun Choe, Han Hahn, Sang June |
| AuthorAffiliation | 6 Department of Physiology, Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Seoul 138-736, Korea 1 Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju 561-180, Korea 5 Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200-701, Korea 3 Department of Pharmaceutical Engineering, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea 2 Department of Physiology, Medical Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea 4 Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA |
| AuthorAffiliation_xml | – name: 1 Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju 561-180, Korea – name: 2 Department of Physiology, Medical Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea – name: 3 Department of Pharmaceutical Engineering, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea – name: 5 Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon 200-701, Korea – name: 6 Department of Physiology, Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Seoul 138-736, Korea – name: 4 Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA |
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| Cites_doi | 10.1038/sj.bjp.0700989 10.1007/BF00656997 10.1074/jbc.M108211200 10.1007/BF03401630 10.1016/S0006-2952(98)00002-1 10.1111/j.1528-1157.1998.tb01152.x 10.1126/science.7604285 10.1002/eji.1830170605 10.1016/S0168-0102(98)00012-1 10.1085/jgp.96.1.195 10.1146/annurev.iy.10.040192.002511 10.1016/j.ejphar.2008.06.094 10.1016/0014-5793(96)00355-9 10.1038/sj.bjp.0706744 10.1016/j.drudis.2006.07.015 10.1113/jphysiol.2006.123414 10.1016/S0006-291X(05)80994-5 10.1111/j.1528-1157.2000.tb00155.x 10.1016/S0162-3109(00)00192-2 10.1016/S0140-6736(99)02107-8 10.1006/bbrc.1996.0582 10.1016/0092-8674(95)90358-5 10.1016/S0006-3495(98)77782-3 |
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| Keywords | Long QT syndrome Open channel block Immunosuppressant HERG Cyclosporin A |
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| References | Cayabyab (10.4196/kjpp.2011.15.5.291_ref20) 2002; 277 Panyi (10.4196/kjpp.2011.15.5.291_ref9) 1996; 221 Jo (10.4196/kjpp.2011.15.5.291_ref22) 2008; 592 Onuma (10.4196/kjpp.2011.15.5.291_ref10) 1998; 30 Steiner (10.4196/kjpp.2011.15.5.291_ref2) 1996; 2 Viskin (10.4196/kjpp.2011.15.5.291_ref14) 1999; 354 Sanguinetti (10.4196/kjpp.2011.15.5.291_ref11) 1990; 96 Wong (10.4196/kjpp.2011.15.5.291_ref6) 2000; 41 Tordai (10.4196/kjpp.2011.15.5.291_ref8) 1992; 185 Hamill (10.4196/kjpp.2011.15.5.291_ref19) 1981; 391 Taubøll (10.4196/kjpp.2011.15.5.291_ref5) 1998; 39 Damjanovich (10.4196/kjpp.2011.15.5.291_ref7) 1987; 17 Suessbrich (10.4196/kjpp.2011.15.5.291_ref17) 1997; 120 Sigal (10.4196/kjpp.2011.15.5.291_ref1) 1992; 10 Cockerill (10.4196/kjpp.2011.15.5.291_ref21) 2007; 581 Taglialatela (10.4196/kjpp.2011.15.5.291_ref16) 1998; 55 Suessbrich (10.4196/kjpp.2011.15.5.291_ref15) 1996; 385 Matsuda (10.4196/kjpp.2011.15.5.291_ref3) 2000; 47 Zhou (10.4196/kjpp.2011.15.5.291_ref18) 1998; 74 Curran (10.4196/kjpp.2011.15.5.291_ref13) 1995; 80 Lee (10.4196/kjpp.2011.15.5.291_ref23) 2006; 148 Trudeau (10.4196/kjpp.2011.15.5.291_ref12) 1995; 269 Italia (10.4196/kjpp.2011.15.5.291_ref4) 2006; 11 7889573 - Cell. 1995 Mar 10;80(5):795-803 9678635 - Neurosci Res. 1998 Apr;30(4):313-9 2439348 - Eur J Immunol. 1987 Jun;17(6):763-8 10560690 - Lancet. 1999 Nov 6;354(9190):1625-33 1375473 - Annu Rev Immunol. 1992;10:519-60 17363390 - J Physiol. 2007 Jun 1;581(Pt 2):479-93 8784785 - Mol Med. 1996 May;2(3):325-33 8641472 - FEBS Lett. 1996 Apr 29;385(1-2):77-80 7604285 - Science. 1995 Jul 7;269(5220):92-5 11834728 - J Biol Chem. 2002 Apr 19;277(16):13673-81 8619842 - Biochem Biophys Res Commun. 1996 Apr 16;221(2):254-8 16633353 - Br J Pharmacol. 2006 Jun;148(4):499-509 9670895 - Epilepsia. 1998 Jul;39(7):687-91 6270629 - Pflugers Arch. 1981 Aug;391(2):85-100 10878286 - Immunopharmacology. 2000 May;47(2-3):119-25 2170562 - J Gen Physiol. 1990 Jul;96(1):195-215 10714397 - Epilepsia. 2000 Mar;41(3):271-6 16935754 - Drug Discov Today. 2006 Sep;11(17-18):846-54 9138706 - Br J Pharmacol. 1997 Mar;120(5):968-74 9449325 - Biophys J. 1998 Jan;74(1):230-41 9714291 - Biochem Pharmacol. 1998 Jun 1;55(11):1741-6 1599474 - Biochem Biophys Res Commun. 1992 May 29;185(1):363-9 18634780 - Eur J Pharmacol. 2008 Sep 11;592(1-3):19-25 |
| References_xml | – volume: 120 start-page: 968 year: 1997 ident: 10.4196/kjpp.2011.15.5.291_ref17 publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0700989 – volume: 391 start-page: 85 year: 1981 ident: 10.4196/kjpp.2011.15.5.291_ref19 publication-title: Pflugers Arch doi: 10.1007/BF00656997 – volume: 277 start-page: 13673 year: 2002 ident: 10.4196/kjpp.2011.15.5.291_ref20 publication-title: J Biol Chem doi: 10.1074/jbc.M108211200 – volume: 2 start-page: 325 year: 1996 ident: 10.4196/kjpp.2011.15.5.291_ref2 publication-title: Mol Med doi: 10.1007/BF03401630 – volume: 55 start-page: 1741 year: 1998 ident: 10.4196/kjpp.2011.15.5.291_ref16 publication-title: Biochem Pharmacol doi: 10.1016/S0006-2952(98)00002-1 – volume: 39 start-page: 687 year: 1998 ident: 10.4196/kjpp.2011.15.5.291_ref5 publication-title: Epilepsia doi: 10.1111/j.1528-1157.1998.tb01152.x – volume: 269 start-page: 92 year: 1995 ident: 10.4196/kjpp.2011.15.5.291_ref12 publication-title: Science doi: 10.1126/science.7604285 – volume: 17 start-page: 763 year: 1987 ident: 10.4196/kjpp.2011.15.5.291_ref7 publication-title: Eur J Immunol doi: 10.1002/eji.1830170605 – volume: 30 start-page: 313 year: 1998 ident: 10.4196/kjpp.2011.15.5.291_ref10 publication-title: Neurosci Res doi: 10.1016/S0168-0102(98)00012-1 – volume: 96 start-page: 195 year: 1990 ident: 10.4196/kjpp.2011.15.5.291_ref11 publication-title: J Gen Physiol doi: 10.1085/jgp.96.1.195 – volume: 10 start-page: 519 year: 1992 ident: 10.4196/kjpp.2011.15.5.291_ref1 publication-title: Annu Rev Immunol doi: 10.1146/annurev.iy.10.040192.002511 – volume: 592 start-page: 19 year: 2008 ident: 10.4196/kjpp.2011.15.5.291_ref22 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2008.06.094 – volume: 385 start-page: 77 year: 1996 ident: 10.4196/kjpp.2011.15.5.291_ref15 publication-title: FEBS Lett doi: 10.1016/0014-5793(96)00355-9 – volume: 148 start-page: 499 year: 2006 ident: 10.4196/kjpp.2011.15.5.291_ref23 publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0706744 – volume: 11 start-page: 846 year: 2006 ident: 10.4196/kjpp.2011.15.5.291_ref4 publication-title: Drug Discov Today doi: 10.1016/j.drudis.2006.07.015 – volume: 581 start-page: 479 year: 2007 ident: 10.4196/kjpp.2011.15.5.291_ref21 publication-title: J Physiol doi: 10.1113/jphysiol.2006.123414 – volume: 185 start-page: 363 year: 1992 ident: 10.4196/kjpp.2011.15.5.291_ref8 publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(05)80994-5 – volume: 41 start-page: 271 year: 2000 ident: 10.4196/kjpp.2011.15.5.291_ref6 publication-title: Epilepsia doi: 10.1111/j.1528-1157.2000.tb00155.x – volume: 47 start-page: 119 year: 2000 ident: 10.4196/kjpp.2011.15.5.291_ref3 publication-title: Immunopharmacology doi: 10.1016/S0162-3109(00)00192-2 – volume: 354 start-page: 1625 year: 1999 ident: 10.4196/kjpp.2011.15.5.291_ref14 publication-title: Lancet doi: 10.1016/S0140-6736(99)02107-8 – volume: 221 start-page: 254 year: 1996 ident: 10.4196/kjpp.2011.15.5.291_ref9 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1996.0582 – volume: 80 start-page: 795 year: 1995 ident: 10.4196/kjpp.2011.15.5.291_ref13 publication-title: Cell doi: 10.1016/0092-8674(95)90358-5 – volume: 74 start-page: 230 year: 1998 ident: 10.4196/kjpp.2011.15.5.291_ref18 publication-title: Biophys J doi: 10.1016/S0006-3495(98)77782-3 – reference: 1375473 - Annu Rev Immunol. 1992;10:519-60 – reference: 9449325 - Biophys J. 1998 Jan;74(1):230-41 – reference: 2170562 - J Gen Physiol. 1990 Jul;96(1):195-215 – reference: 9138706 - Br J Pharmacol. 1997 Mar;120(5):968-74 – reference: 18634780 - Eur J Pharmacol. 2008 Sep 11;592(1-3):19-25 – reference: 16935754 - Drug Discov Today. 2006 Sep;11(17-18):846-54 – reference: 9714291 - Biochem Pharmacol. 1998 Jun 1;55(11):1741-6 – reference: 2439348 - Eur J Immunol. 1987 Jun;17(6):763-8 – reference: 10714397 - Epilepsia. 2000 Mar;41(3):271-6 – reference: 11834728 - J Biol Chem. 2002 Apr 19;277(16):13673-81 – reference: 8619842 - Biochem Biophys Res Commun. 1996 Apr 16;221(2):254-8 – reference: 1599474 - Biochem Biophys Res Commun. 1992 May 29;185(1):363-9 – reference: 9678635 - Neurosci Res. 1998 Apr;30(4):313-9 – reference: 8784785 - Mol Med. 1996 May;2(3):325-33 – reference: 10560690 - Lancet. 1999 Nov 6;354(9190):1625-33 – reference: 16633353 - Br J Pharmacol. 2006 Jun;148(4):499-509 – reference: 8641472 - FEBS Lett. 1996 Apr 29;385(1-2):77-80 – reference: 7889573 - Cell. 1995 Mar 10;80(5):795-803 – reference: 17363390 - J Physiol. 2007 Jun 1;581(Pt 2):479-93 – reference: 9670895 - Epilepsia. 1998 Jul;39(7):687-91 – reference: 6270629 - Pflugers Arch. 1981 Aug;391(2):85-100 – reference: 10878286 - Immunopharmacology. 2000 May;47(2-3):119-25 – reference: 7604285 - Science. 1995 Jul 7;269(5220):92-5 |
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