Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

• Published in: Cell metabolism Vol. 30; no. 6; pp. 1152 - 1170.e13
• Main Authors: Zivanovic, Jasmina, Kouroussis, Emilia, Kohl, Joshua B., Adhikari, Bikash, Bursac, Biljana, Schott-Roux, Sonia, Petrovic, Dunja, Miljkovic, Jan Lj, Thomas-Lopez, Daniel, Jung, Youngeun, Miler, Marko, Mitchell, Sarah, Milosevic, Verica, Gomes, Jose Eduardo, Benhar, Moran, Gonzalez-Zorn, Bruno, Ivanovic-Burmazovic, Ivana, Torregrossa, Roberta, Mitchell, James R., Whiteman, Matthew, Schwarz, Guenter, Snyder, Solomon H., Paul, Bindu D., Carroll, Kate S., Filipovic, Milos R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2019; Elsevier
• Subjects: aging; Aging - metabolism; Animals; Caenorhabditis elegans; calorie restriction; Cell Line; Cyclohexanones - chemistry; Cysteine - chemistry; Cysteine - metabolism; Drosophila melanogaster; Escherichia coli; Fibroblasts; Humans; hydrogen peroxide; hydrogen sulfide; Hydrogen Sulfide - metabolism; Life Sciences; Male; Mice; Mice, Inbred C57BL; Oxidative Stress - physiology; protein persulfidation; Protein Processing, Post-Translational - physiology; Rats; Rats, Wistar; redox signaling; Saccharomyces cerevisiae; Staining and Labeling; sulfenylation; Sulfides - metabolism; sulfinylation; sulfonylation; redox signaling; protein persulfidation; calorie restriction; hydrogen sulfide; sulfonylation; hydrogen peroxide; sulfinylation; sulfenylation; aging

Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism. Protein persulfidation (S-sulfhydration) is a post-translational modification of reactive cysteine residues, which modulate protein structu...