Acute Behavioral Toxicity of Pyridostigmine or Soman in Primates

• Published in: Toxicology and applied pharmacology Vol. 126; no. 2; pp. 311 - 318
• Main Authors: Blick, D.W., Murphy, M.R., Brown, G.C., Yochmowitz, M.G., Fanton, J.W., Hartgraves, S.L.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.06.1994; Elsevier
• Subjects: Animals; Behavior, Animal - drug effects; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Cholinesterases - blood; Dose-Response Relationship, Drug; Macaca mulatta; Male; Medical sciences; Pyridostigmine Bromide - toxicity; Soman - toxicity; Toxicology; Various organic compounds; Nervous system diseases; Toxicity; Acute; Monkey; Tracking task; Organic carbamate; Vertebrata; Mammalia; Animal; Primates; Organophosphorus compounds; Anticholinesterase agent; Behavior; Soman; Carbamate; Comparative study

Effects of a peripherally active carbamate (pyridostigmine bromide) and a centrally active organophosphate (OP) nerve agent (soman) on performance by rhesus monkeys of a compensatory tracking (primate equilibrium platform, or PEP) task were measured using a balanced Latin-square design to determine...