Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review

• Published in: Journal of Zhejiang University. B. Science Vol. 25; no. 4; pp. 280 - 292
• Main Authors: Lin, Siyi, He, Xinyu, Wang, Ying, Chen, Yu, Lin, Aifu
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.04.2024; Springer Nature B.V; Key Laboratory for Cell and Gene Engineering of Zhejiang Province,Hangzhou 310058,China%College of Life Sciences,Zhejiang University,Hangzhou 310058,China; International School of Medicine,International Institutes of Medicine,the Fourth Affiliated Hospital of Zhejiang University School of Medicine,Yiwu 322000,China; Future Health Laboratory,Innovation Center of Yangtze River Delta,Zhejiang University,Jiaxing 314100,China; College of Medicine,Zhejiang University,Hangzhou 310058,China%College of Life Sciences,Zhejiang University,Hangzhou 310058,China; Key Laboratory for Cell and Gene Engineering of Zhejiang Province,Hangzhou 310058,China; Cancer Center,Zhejiang University,Hangzhou 310058,China; Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Hangzhou 310058,China
• Subjects: Biomedical and Life Sciences; Biomedicine; Cytoskeleton; Extracellular signal-regulated kinase; Hydrostatic pressure; Kinases; Mechanical stimuli; Mechanoreceptors; Mechanotransduction; Microenvironments; Non-coding RNA; Pathogenesis; Phenotypes; Review; Shear stress; Stimuli; Wnt protein; Yes-associated protein; 机械转导; F-actin; Long non-coding RNA (lncRNA); YAP/TAZ; F-肌动蛋白; 长链非编码RNA(lncRNA); Mechanotransduction; Long non-coding RNA(lncRNA)

Cells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes, shaping the microenvironmen...