Demonstration of Functional Cytokine-Placental Interactions: CSF-1 and GM-CSF Stimulate Human Cytotrophoblast Differentiation and Peptide Hormone Secretion

• Published in: Experimental cell research Vol. 214; no. 1; pp. 46 - 54
• Main Authors: Garcia-Lloret, Maria I., Morrish, Donald W., Wegmann, Thomas G., Honore, Louis, Turner, A.Robert, Guilbert, Larry J.
• Format: Journal Article
• Language: English
• Published: Orlando, FL Elsevier Inc 01.09.1994; Elsevier
• Subjects: Biological and medical sciences; Cell Differentiation - drug effects; Cells, Cultured; Chorionic Gonadotropin - secretion; Cytokines - pharmacology; Drug Interactions; Embryology: invertebrates and vertebrates. Teratology; Fetal membranes; Fibroblasts - drug effects; Fibroblasts - metabolism; Fundamental and applied biological sciences. Psychology; General aspects. Development. Fetal membranes; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology; Humans; Interleukin-1 - pharmacology; Macrophage Colony-Stimulating Factor - pharmacology; Placental Lactogen - secretion; Receptor, Macrophage Colony-Stimulating Factor - biosynthesis; Trophoblasts - cytology; Trophoblasts - drug effects; Trophoblasts - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Up-Regulation; Human; Trophoblaste; Placenta; Fetal membrane; Secretion; Morphology; Cytokine; Differentiation

The placental syncytiotrophoblast (ST) is a terminally differentiated epithelial cell monolayer that constitutes the outermost boundary between fetal and maternal tissues and performs a variety of synthetic, secretory, and transport functions essential for the maintenance of pregnancy. Although it i...