An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling design

• Published in: Biomarkers Vol. 13; no. 6; pp. 560 - 578
• Main Authors: Fustinoni, S., Campo, L., Manini, P., Buratti, M., Waidyanatha, S., De Palma, G., Mutti, A., Foa, V, Colombi, A., Rappaport, S. M.
• Format: Journal Article
• Language: English
• Published: London Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: Acetylcysteine - urine; Adult; Air Pollutants, Occupational - urine; Biological and medical sciences; Biomarkers - blood; Biomarkers - urine; Biotransformation; Chemical and industrial products toxicology. Toxic occupational diseases; Chemical Industry; Environmental Monitoring - methods; Epoxy Compounds - urine; Ethylene Glycols - urine; exposure assessment; Female; Glutathione Transferase - genetics; Hemoglobins - analysis; Humans; Male; Medical sciences; Middle Aged; Occupational Exposure; Phenols - urine; Polymorphism, Genetic; protein adducts; Serum Albumin - analysis; Smoking - urine; Solvents; styrene; Styrene - urine; styrene-(7,8)-oxide; Toxicology; urinary biomarkers; Human; Urine; protein adducts; styrene-(7,8)-oxide; Samplings; Biological marker; exposure assessment; Occupational exposure; Protein; Biological monitoring; Organic solvent; Styrene; urinary biomarkers; Sampling; Occupational medicine; Molecular adduct; Adduct

Abstract The aim of this work was to investigate urinary analytes and haemoglobin and albumin adducts as biomarkers of exposure to airborne styrene (Sty) and styrene-(7,8)-oxide (StyOX) and to evaluate the influence of smoking habit and genetic polymorphism of metabolic enzymes GSTM1 and GSTT1 on th...