CD73/5'-ecto-nucleotidase acts as a regulatory factor in osteo-/chondrogenic differentiation of mechanically stimulated mesenchymal stromal cells

• Published in: European cells & materials Vol. 25; pp. 37 - 47
• Main Authors: Ode, A, Schoon, J, Kurtz, A, Gaetjen, M, Ode, J E, Geissler, S, Duda, G N
• Format: Journal Article
• Language: English
• Published: Switzerland Forum Multimedia Publishing LLC 08.01.2013
• Subjects: 5'-Nucleotidase - antagonists & inhibitors; 5'-Nucleotidase - metabolism; Adenosine Diphosphate - analogs & derivatives; Adenosine Diphosphate - pharmacology; Alkaline Phosphatase - metabolism; Animals; Antigens, CD - metabolism; CD73/5’-ecto-nucleotidase; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrogenesis; chondrogenic differentiation; Gene Expression; Male; mechanical stimulation; Mesenchymal Stem Cells - enzymology; Mesenchymal Stem Cells - physiology; Mesenchymal stromal cells; Osteoblasts - enzymology; Osteogenesis; osteogenic differentiation; Rats; Rats, Inbred Lew; Receptor, Adenosine A2A - genetics; Receptor, Adenosine A2A - metabolism; Signal Transduction

Bone regeneration is influenced by mesenchymal stromal cells (MSCs) and mechanical conditions. How healing outcome and mechanical stability are linked on the cellular level, however, remains elusive. Cyclic-compressive loading of MSCs affects the expression of molecules involved in angiogenesis and...