Restoration of Impaired Endothelial Myocyte Enhancer Factor 2 Function Rescues Pulmonary Arterial Hypertension - Kim, Jongmin; Hwangbo, Cheol; Hu, Xiaoyue; Kang, Yujung; Papangeli, Irinna; Mehrotra, Devi; Park, Hyekyung; Ju, Hyekyung; McLean, Danielle L.; Comhair, Suzy A.; Erzurum, Serpil C.; Chun, Hyung J. (Circulation (New York, N.Y.), 2015)
Keywords: Animals; Apelin; Arterioles - pathology; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells - drug effects; Endothelial Cells - pathology; Fibroblast Growth Factor 2 - biosynthesis; Fibroblast Growth Factor 2 - genetics; Hemodynamics; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylase Inhibitors - therapeutic use; Hydroxamic Acids - pharmacology; Hydroxamic Acids - therapeutic use; Hypertension, Pulmonary; Hypertrophy, Right Ventricular - etiology; Hypertrophy, Right Ventricular - prevention & control; Hypoxia - complications; Intercellular Signaling Peptides and Proteins - pharmacology; Male; MEF2 Transcription Factors - genetics; MEF2 Transcription Factors - physiology; MicroRNAs - biosynthesis; Monocrotaline; Pulmonary Artery - pathology; Pyrroles - pharmacology; Pyrroles - therapeutic use; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering - pharmacology; Transcription, Genetic; endothelial cells; pulmonary hypertension; transcriptional activation