Flavone-8-acetic acid (flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury in vivo

• Published in: Circulation (New York, N.Y.) Vol. 101; no. 3; pp. 324 - 328
• Main Authors: MRUK, J. S, WEBSTER, M. W. I, HERAS, M, REID, J. M, GRILL, D. E, CHESEBRO, J. H
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 25.01.2000; American Heart Association, Inc
• Subjects: Animals; Antineoplastic Agents - pharmacology; Biological and medical sciences; Blood Platelets - drug effects; Blood. Blood coagulation. Reticuloendothelial system; Catheterization; Flavonoids - pharmacokinetics; Flavonoids - pharmacology; Medical sciences; Pharmacology. Drug treatments; Platelet Glycoprotein GPIb-IX Complex - antagonists & inhibitors; Swine; Thrombosis - drug therapy; Vasoconstriction - drug effects; Vasoconstriction; Instrumentation therapy; Cardiovascular disease; Instrumental dilatation; Flavonoid; Thrombosis; Artery; Antiplatelet agent; Pig; Arterial disease; Vascular disease; Aggregation; Prevention; Restenosis; Vertebrata; Chemotherapy; Platelet; Mammalia; Treatment; Animal; Complication; Artiodactyla; Ungulata

Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumor drug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. (111)In-labeled au...