Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier

• Published in: Cephalalgia Vol. 40; no. 3; pp. 229 - 240
• Main Authors: Noseda, Rodrigo, Schain, Aaron J, Melo-Carrillo, Agustin, Tien, Jason, Stratton, Jennifer, Mai, Fanny, Strassman, Andrew M, Burstein, Rami
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.03.2020
• Subjects: Original; trigeminovascular; headache; CSD; CGRP; Migraine; monoclonal antibodies

Background The presence of calcitonin gene-related peptide and its receptors in multiple brain areas and peripheral tissues previously implicated in migraine initiation and its many associated symptoms raises the possibility that humanized monoclonal anti-calcitonin gene-related peptide antibodies (...