Imaging biomarkers of vascular and axonal injury are spatially distinct in chronic traumatic brain injury

• Published in: Journal of cerebral blood flow and metabolism Vol. 41; no. 8; pp. 1924 - 1938
• Main Authors: Haber, Margalit, Amyot, Franck, Lynch, Cillian E, Sandsmark, Danielle K, Kenney, Kimbra, Werner, John K, Moore, Carol, Flesher, Kelley, Woodson, Sarah, Silverman, Erika, Chou, Yiyu, Pham, Dzung, Diaz-Arrastia, Ramon
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2021
• Subjects: Adult; Anisotropy; Axons - pathology; Biomarkers - metabolism; Brain - blood supply; Brain - physiopathology; Brain - ultrastructure; Brain Injuries, Traumatic - diagnostic imaging; Brain Injuries, Traumatic - pathology; Brain Injury, Chronic - diagnostic imaging; Brain Injury, Chronic - pathology; Brain Mapping; Case-Control Studies; Cerebrovascular Circulation - physiology; Female; Humans; Hypercapnia - diagnostic imaging; Hypocapnia - physiopathology; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Original; Spin Labels; cerebral blood flow; axonal injury; Traumatic brain injury; cerebrovascular reactivity; biomarker

Traumatic Brain Injury (TBI) is associated with both diffuse axonal injury (DAI) and diffuse vascular injury (DVI), which result from inertial shearing forces. These terms are often used interchangeably, but the spatial relationships between DAI and DVI have not been carefully studied. Multimodal ma...