Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine

• Published in: Journal of cerebral blood flow and metabolism Vol. 40; no. 1; pp. 187 - 203
• Main Authors: Ko, Tiffany S, Mavroudis, Constantine D, Baker, Wesley B, Morano, Vincent C, Mensah-Brown, Kobina, Boorady, Timothy W, Schmidt, Alexander L, Lynch, Jennifer M, Busch, David R, Gentile, Javier, Bratinov, George, Lin, Yuxi, Jeong, Sejin, Melchior, Richard W, Rosenthal, Tami M, Shade, Brandon C, Schiavo, Kellie L, Xiao, Rui, Gaynor, J William, Yodh, Arjun G, Kilbaugh, Todd J, Licht, Daniel J
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2020
• Subjects: Animals; Animals, Newborn; Body Temperature; Brain - metabolism; Brain - physiology; Cardiopulmonary Bypass - methods; Hypothermia, Induced; Models, Animal; Monitoring, Physiologic - methods; Original; Oxygen - metabolism; Perfusion; Spectrum Analysis - methods; Swine; Cerebral oxygen metabolism; cardiopulmonary bypass; diffuse correlation spectroscopy; deep hypothermia; diffuse optical spectroscopy

Management of deep hypothermic (DH) cardiopulmonary bypass (CPB), a critical neuroprotective strategy, currently relies on non-invasive temperature to guide cerebral metabolic suppression during complex cardiac surgery in neonates. Considerable inter-subject variability in temperature response and r...