Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view

Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to T...

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Published inImmunologic research Vol. 40; no. 1; pp. 1 - 17
Main Authors Roumier, Thomas, Capron, Monique, Dombrowicz, David, Faveeuw, Christelle
Format Journal Article
LanguageEnglish
Published New York Humana Press Inc 2008
Springer Nature B.V
Humana Press
Subjects
Allergies
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Communicable Diseases - immunology
Human health and pathology
Humans
Hypersensitivity - immunology
Immunology
Infectious diseases
Internal Medicine
Life Sciences
Medicine/Public Health
Pathogens
Studies
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Regulatory - immunology
Th1 Cells - immunology
Th2 Cells - immunology
Parasite
Hygiene hypothesis
Allergy
Regulatory cell
Th1/Th2 paradigm
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Summary:Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to Th1 responses. In this review, we will examine and compare the various mechanisms by which Th1- or Th2-inducing infectious agents regulate the development of atopic diseases. We will emphasize the key role of various regulatory cell populations associated to the immune responses toward pathogen.
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ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-007-0058-3