New agents modulating the renin-angiotensin-aldosterone system—Will there be a new therapeutic option?

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 241; no. 17; pp. 1888 - 1899
• Main Authors: Gromotowicz-Poplawska, Anna, Szoka, Piotr, Kolodziejczyk, Patrycjusz, Kramkowski, Karol, Wojewodzka-Zelezniakowicz, Marzena, Chabielska, Ewa
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.2016
• Subjects: Aldosterone - physiology; Angiotensin I - physiology; Animals; Cytochrome P-450 CYP11B2 - antagonists & inhibitors; Humans; Mineralocorticoid Receptor Antagonists - pharmacology; Minireview; Peptide Fragments - physiology; Peptidyl-Dipeptidase A - drug effects; Peptidyl-Dipeptidase A - physiology; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; aldosterone synthase inhibitors; angiotensin-(1-7); finerenone; Angiotensin converting enzyme 2; Mas receptor; mineralocorticoid receptor coregulators

The renin-angiotensin-aldosterone system (RAAS) is more complex than it was originally regarded. According to the current subject knowledge, there are two main axes of the RAAS: (1) angiotensin-converting enzyme (ACE)-angiotensin II-AT1 receptor axis and (2) ACE2-angiotensin-(1-7)-Mas receptor axis....