Cancer-derived small extracellular vesicles: emerging biomarkers and therapies for pancreatic ductal adenocarcinoma diagnosis/prognosis and treatment

• Published in: Journal of nanobiotechnology Vol. 20; no. 1; p. 446
• Main Authors: Zhang, Wei, Campbell, Douglas H, Walsh, Bradley J, Packer, Nicolle H, Liu, Dingbin, Wang, Yuling
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.10.2022; BioMed Central; BMC
• Subjects: Adenocarcinoma; Biomarkers; Biomarkers, Tumor - metabolism; Biomolecules; Biopsy; Body fluids; Cancer; Cancer diagnosis/prognosis; Cancer therapies; Cancer treatment; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - therapy; Care and treatment; Clinical outcomes; Diagnosis; Drug carriers; Drug Carriers - therapeutic use; Drug delivery; Extracellular vesicles; Extracellular Vesicles - metabolism; Gene expression; Humans; Identification and classification; Immunotherapy; Lipids; Medical diagnosis; Medical prognosis; Metastasis; Pancreas; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - therapy; Pancreatitis; Patients; Polysaccharides; Prognosis; Proteins; Review; Signal transduction; Tumor markers; Tumorigenesis; Tumors; Vesicles; China; United States > US; Extracellular vesicles; Cancer diagnosis/prognosis; Cancer treatment; Pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages and effective therapeutic strategies for the treatment. Cancer-derived small extracellular v...