Cancer-derived small extracellular vesicles: emerging biomarkers and therapies for pancreatic ductal adenocarcinoma diagnosis/prognosis and treatment

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages and effective therapeutic strategies for the treatment. Cancer-derived small extracellular v...

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Published inJournal of nanobiotechnology Vol. 20; no. 1; p. 446
Main Authors Zhang, Wei, Campbell, Douglas H, Walsh, Bradley J, Packer, Nicolle H, Liu, Dingbin, Wang, Yuling
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 14.10.2022
BioMed Central
BMC
Subjects
Adenocarcinoma
Biomarkers
Biomarkers, Tumor - metabolism
Biomolecules
Biopsy
Body fluids
Cancer
Cancer diagnosis/prognosis
Cancer therapies
Cancer treatment
Carcinoma, Pancreatic Ductal - drug therapy
Carcinoma, Pancreatic Ductal - therapy
Care and treatment
Clinical outcomes
Diagnosis
Drug carriers
Drug Carriers - therapeutic use
Drug delivery
Extracellular vesicles
Extracellular Vesicles - metabolism
Gene expression
Humans
Identification and classification
Immunotherapy
Lipids
Medical diagnosis
Medical prognosis
Metastasis
Pancreas
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - therapy
Pancreatitis
Patients
Polysaccharides
Prognosis
Proteins
Review
Signal transduction
Tumor markers
Tumorigenesis
Tumors
Vesicles
China
United States > US
Extracellular vesicles
Cancer diagnosis/prognosis
Cancer treatment
Pancreatic cancer
Online AccessGet full text

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages and effective therapeutic strategies for the treatment. Cancer-derived small extracellular vesicles (sEVs), which carry various messages and signal biomolecules (e.g. RNAs, DNAs, proteins, lipids, and glycans) to constitute the key features (e.g. genetic and phenotypic status) of cancer cells, are regarded as highly competitive non-invasive biomarkers for PDAC diagnosis/prognosis. Additionally, new insights on the biogenesis and molecular functions of cancer-derived sEVs pave the way for novel therapeutic strategies based on cancer-derived sEVs for PDAC treatment such as inhibition of the formation or secretion of cancer-derived sEVs, using cancer-derived sEVs as drug carriers and for immunotherapy. This review provides a comprehensive overview of the most recent scientific and clinical research on the discovery and involvement of key molecules in cancer-derived sEVs for PDAC diagnosis/prognosis and strategies using cancer-derived sEVs for PDAC treatment. The current limitations and emerging trends toward clinical application of cancer-derived sEVs in PDAC diagnosis/prognosis and treatment have also been discussed.
AbstractList Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages and effective therapeutic strategies for the treatment. Cancer-derived small extracellular vesicles (sEVs), which carry various messages and signal biomolecules (e.g. RNAs, DNAs, proteins, lipids, and glycans) to constitute the key features (e.g. genetic and phenotypic status) of cancer cells, are regarded as highly competitive non-invasive biomarkers for PDAC diagnosis/prognosis. Additionally, new insights on the biogenesis and molecular functions of cancer-derived sEVs pave the way for novel therapeutic strategies based on cancer-derived sEVs for PDAC treatment such as inhibition of the formation or secretion of cancer-derived sEVs, using cancer-derived sEVs as drug carriers and for immunotherapy. This review provides a comprehensive overview of the most recent scientific and clinical research on the discovery and involvement of key molecules in cancer-derived sEVs for PDAC diagnosis/prognosis and strategies using cancer-derived sEVs for PDAC treatment. The current limitations and emerging trends toward clinical application of cancer-derived sEVs in PDAC diagnosis/prognosis and treatment have also been discussed.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages and effective therapeutic strategies for the treatment. Cancer-derived small extracellular vesicles (sEVs), which carry various messages and signal biomolecules (e.g. RNAs, DNAs, proteins, lipids, and glycans) to constitute the key features (e.g. genetic and phenotypic status) of cancer cells, are regarded as highly competitive non-invasive biomarkers for PDAC diagnosis/prognosis. Additionally, new insights on the biogenesis and molecular functions of cancer-derived sEVs pave the way for novel therapeutic strategies based on cancer-derived sEVs for PDAC treatment such as inhibition of the formation or secretion of cancer-derived sEVs, using cancer-derived sEVs as drug carriers and for immunotherapy. This review provides a comprehensive overview of the most recent scientific and clinical research on the discovery and involvement of key molecules in cancer-derived sEVs for PDAC diagnosis/prognosis and strategies using cancer-derived sEVs for PDAC treatment. The current limitations and emerging trends toward clinical application of cancer-derived sEVs in PDAC diagnosis/prognosis and treatment have also been discussed. Keywords: Pancreatic cancer, Extracellular vesicles, Cancer diagnosis/prognosis, Cancer treatment
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages and effective therapeutic strategies for the treatment. Cancer-derived small extracellular vesicles (sEVs), which carry various messages and signal biomolecules (e.g. RNAs, DNAs, proteins, lipids, and glycans) to constitute the key features (e.g. genetic and phenotypic status) of cancer cells, are regarded as highly competitive non-invasive biomarkers for PDAC diagnosis/prognosis. Additionally, new insights on the biogenesis and molecular functions of cancer-derived sEVs pave the way for novel therapeutic strategies based on cancer-derived sEVs for PDAC treatment such as inhibition of the formation or secretion of cancer-derived sEVs, using cancer-derived sEVs as drug carriers and for immunotherapy. This review provides a comprehensive overview of the most recent scientific and clinical research on the discovery and involvement of key molecules in cancer-derived sEVs for PDAC diagnosis/prognosis and strategies using cancer-derived sEVs for PDAC treatment. The current limitations and emerging trends toward clinical application of cancer-derived sEVs in PDAC diagnosis/prognosis and treatment have also been discussed.
ArticleNumber 446
Audience Academic
Author Campbell, Douglas H
Packer, Nicolle H
Walsh, Bradley J
Liu, Dingbin
Wang, Yuling
Zhang, Wei
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  organization: Minomic International Ltd, Macquarie Park, 2113, Sydney, NSW, Australia
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  givenname: Nicolle H
  surname: Packer
  fullname: Packer, Nicolle H
  organization: School of Natural Sciences, Faculty of Science and Engineering, ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, 2109, Sydney, NSW, Australia
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  givenname: Yuling
  surname: Wang
  fullname: Wang, Yuling
  email: yuling.wang@mq.edu.au
  organization: School of Natural Sciences, Faculty of Science and Engineering, ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, 2109, Sydney, NSW, Australia. yuling.wang@mq.edu.au
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Issue 1
Keywords Extracellular vesicles
Cancer diagnosis/prognosis
Cancer treatment
Pancreatic cancer
Language English
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Snippet Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable...
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SubjectTerms Adenocarcinoma
Biomarkers
Biomarkers, Tumor - metabolism
Biomolecules
Biopsy
Body fluids
Cancer
Cancer diagnosis/prognosis
Cancer therapies
Cancer treatment
Carcinoma, Pancreatic Ductal - drug therapy
Carcinoma, Pancreatic Ductal - therapy
Care and treatment
Clinical outcomes
Diagnosis
Drug carriers
Drug Carriers - therapeutic use
Drug delivery
Extracellular vesicles
Extracellular Vesicles - metabolism
Gene expression
Humans
Identification and classification
Immunotherapy
Lipids
Medical diagnosis
Medical prognosis
Metastasis
Pancreas
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - therapy
Pancreatitis
Patients
Polysaccharides
Prognosis
Proteins
Review
Signal transduction
Tumor markers
Tumorigenesis
Tumors
Vesicles
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Title Cancer-derived small extracellular vesicles: emerging biomarkers and therapies for pancreatic ductal adenocarcinoma diagnosis/prognosis and treatment
URI https://www.ncbi.nlm.nih.gov/pubmed/36242076
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