Comprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson’s disease

• Published in: Scientific reports Vol. 5; no. 1; p. 13888
• Main Authors: Luan, Hemi, Liu, Liang-Feng, Tang, Zhi, Zhang, Manwen, Chua, Ka-Kit, Song, Ju-Xian, Mok, Vincent C.T., Li, Min, Cai, Zongwei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.09.2015; Nature Publishing Group
• Subjects: 631/45/320; 692/53/2421; 692/699/375/1718; Adult; Aged; Aged, 80 and over; Amino acids; Amino Acids - metabolism; Biomarkers - urine; Biosynthesis; Case-Control Studies; Chromatography; Chromatography, High Pressure Liquid; Discriminant Analysis; Disease Progression; Female; Gas chromatography; Gas Chromatography-Mass Spectrometry; Glycine; Humanities and Social Sciences; Humans; Least-Squares Analysis; Liquid chromatography; Male; Mass Spectrometry; Mass spectroscopy; Metabolism; Metabolites; Metabolome; Metabolomics; Middle Aged; Movement disorders; multidisciplinary; Neurodegenerative diseases; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Phenotype; Phenotyping; Phenylalanine; Quality control; Science; Scientific imaging; Severity of Illness Index; Tryptophan; Urine

Urine metabolic phenotyping has been associated with the development of Parkinson’s disease (PD). However, few studies using a comprehensive metabolomics approach have investigated the correlation between changes in the urinary markers and the progression of clinical symptoms in PD. A comprehensive...