The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter

• Published in: Journal of lipid research Vol. 48; no. 8; pp. 1781 - 1791
• Main Authors: Dongol, Bikesh, Shah, Yatrik, Kim, Insook, Gonzalez, Frank J., Hunt, Mary C.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.08.2007; American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: acyl-coenzyme A; direct repeat 1; hepatic nuclear factor 4α; lipid metabolism; peroxisome proliferator response element; peroxisome proliferator-activated receptor α; acyl-coenzyme A; direct repeat 1; hepatic nuclear factor 4α; peroxisome proliferator response element; lipid metabolism; peroxisome proliferator-activated receptor α

The cytosolic acyl-coenzyme A thioesterase I (Acot1) is an enzyme that hydrolyzes long-chain acyl-CoAs of C12-C20-CoA in chain length to the free fatty acid and CoA. Acot1 was shown previously to be strongly upregulated at the mRNA and protein level in rodents by fibrates. In this study, we show tha...