Esm-1 mediates transcriptional polarization associated with diabetic kidney disease

• Published in: American journal of physiology. Renal physiology Vol. 326; no. 6; pp. F1016 - F1031
• Main Authors: Gaudet, Alexandre, Zheng, Xiaoyi, Kambham, Neeraja, Bhalla, Vivek
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2024
• Subjects: Animals; Case-Control Studies; Chemotaxis; Diabetes; Diabetes mellitus; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Endothelial cells; Endothelial Cells - metabolism; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Humans; Kidney diseases; Kidney Glomerulus - metabolism; Kidney Glomerulus - pathology; Mice; Neoplasm Proteins; Polarization; Proteoglycans; Proteoglycans - genetics; Proteoglycans - metabolism; Transcription; Transcription, Genetic; Transcriptome; Transcriptomes; diabetic kidney disease; inflammation; immunology; angiogenesis; single-cell RNA

Esm-1 is primarily expressed in glomerular endothelium in humans. Cells expressing Esm1 exhibit a high degree of conservation in the enrichment of genes related to blood vessel development. In the context of diabetes, these cells are reduced in number and show a significant transcriptional shift tow...