Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity

An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high e...

Full description

Saved in:
Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 22; p. 7602
Main Authors Li, Xue, Chen, Xing-Yu, Fan, Bing-Ying, Yu, Qun, Lei, Jie, Xu, Zhi-Gang, Chen, Zhong-Zhu
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2023
Subjects
3-formylchromones
anti-cancer activity
Cancer
Care and treatment
decarboxylation
metal-free
Natural products
Oxidation
Polymerization
pyrroles
China
Online AccessGet full text

Cover

More Information
Summary:An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC50 value of 10.65 μM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28227602