Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster

• Published in: Journal of biochemistry (Tokyo) Vol. 168; no. 5; pp. 477 - 489
• Main Authors: Matsuura, Yuki, Noguchi, Aya, Sakai, Shunsuke, Yokota, Naoto, Kawahara, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2020
• Subjects: Butyrate Response Factor 1 - metabolism; Cell Cycle - physiology; Cell Nucleus - metabolism; Female; HeLa Cells; Humans; Nuclear Localization Signals - metabolism; Protein Domains; RNA Stability; Serine - chemistry; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; intronic ARE; ZFP36; nuclear RNA-binding protein; cell cycle; CCCH-zinc finger domain

Abstract ZFP36L1 is an RNA-binding protein responsible for mRNA decay in the cytoplasm. ZFP36L1 has also been suggested as a nuclear-cytoplasmic shuttling protein because it contains a potential nuclear localization signal and a nuclear export signal. However, it remains unclear how the nuclear loca...