Principles for Valid Histopathologic Scoring in Research

• Published in: Veterinary pathology Vol. 50; no. 6; pp. 1007 - 1015
• Main Authors: Gibson-Corley, K. N., Olivier, A. K., Meyerholz, D. K.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.2013
• Subjects: Animals; Disease Models, Animal; Pathology - methods; Research Design - standards; Severity of Illness Index; Validation Studies as Topic; semiquantitative; scoring; grading; lesions; histopathology; validation; ordinal

Histopathologic scoring is a tool by which semiquantitative data can be obtained from tissues. Initially, a thorough understanding of the experimental design, study objectives, and methods is required for the pathologist to appropriately examine tissues and develop lesion scoring approaches. Many pr...