Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?

• Published in: Fundamental & clinical pharmacology Vol. 21; no. 5; pp. 467 - 480
• Main Authors: Strolin Benedetti, Margherita, Tipton, Keith F., Whomsley, Rhys
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2007; Blackwell
• Subjects: Amine Oxidase (Copper-Containing) - metabolism; amine oxidases; Amines - metabolism; Biological and medical sciences; Cytochrome P-450 Enzyme System - metabolism; cytochrome P450; Flavin-Adenine Dinucleotide - metabolism; flavin-containing monooxygenases; Humans; Medical sciences; Mixed Function Oxygenases - metabolism; Monoamine Oxidase - metabolism; monoamine oxidases; monooxygenases; Oxidoreductases Acting on CH-NH Group Donors - metabolism; Pharmacology. Drug treatments; Polyamine Oxidase; xenobiotic metabolism; Xenobiotics - metabolism; Human; Enzyme; Cytochrome P450; Oxidase; flavin-containing monooxygenases; Metabolism; Amine oxidase (flavin-containing); xenobiotic metabolism; Dimethylaniline monooxygenase (N-oxide-forming); In vivo; amine oxidases; Oxidoreductases; Pharmacokinetics; Xenobiotic; monoamine oxidases. monooxygenases

In this review, the major enzyme systems involved in vivo in the oxidative metabolism of xenobiotic amines in humans are discussed, i.e. the monooxygenases [cytochrome P450 system (CYPs) and flavin‐containing monooxygenases (FMOs)] and the amine oxidases (AOs). Concerning the metabolism of xenobioti...