Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide

• Published in: Journal of cardiovascular pharmacology Vol. 20; no. 3; p. 451
• Main Authors: Krum, H, Jackson, B, Conway, E L, Howes, L G, Johnston, C I, Louis, W J
• Format: Journal Article
• Language: English
• Published: United States 01.09.1992
• Subjects: Aged; Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Blood Pressure - drug effects; Cilazapril - pharmacokinetics; Cilazapril - pharmacology; Cilazapril - therapeutic use; Cyclopenthiazide - pharmacology; Cyclopenthiazide - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate - drug effects; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged

Twenty-two patients with essential hypertension received a single dose of 2.5 mg cilazapril and were then randomised into a double-blind parallel group study to receive either placebo, 1.25 mg cilazapril + 0.5 mg cyclopenthiazide (CPTZ), 2.5 mg cilazapril + 0.5 mg CPTZ, or 2.5 mg cilazapril alone fo...