Palladium-Catalyzed Dearomative Cyclocarbonylation by CN Bond Activation

• Published in: Angewandte Chemie International Edition Vol. 54; no. 37; pp. 10912 - 10916
• Main Authors: Yu, Hui, Zhang, Guoying, Huang, Hanmin
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 07.09.2015; WILEY‐VCH Verlag
• Subjects: Activation; Biocompatibility; Bonding; Carbonyls; Catalysis; Cobalt; Cyclization; cyclocarbonylation; CN activation; dearomatization; Insertion; Ketones - chemistry; palladium; Palladium - chemistry; quinolizinones; Synthesis; Transformations; CN activation; palladium; quinolizinones; cyclocarbonylation; dearomatization

A fundamentally novel approach to bioactive quinolizinones is based on the palladium‐catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I2], which features a very large bite angle, has been found to facilitate the rapid carbonylation of azaarene‐substituted allylamines into bio...