The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism
Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessi...
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| Published in | Endocrine reviews Vol. 37; no. 4; pp. 403 - 416 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.08.2016
Copyright by The Endocrine Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0163-769X 1945-7189 1945-7189 |
| DOI | 10.1210/er.2016-1009 |
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| Abstract | Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessive weight gain, becomes infiltrated with macrophages and lymphocytes and undergoes important changes in its gene expression. Haptoglobin (Hp), a typical marker of inflammation in clinical practice, main carrier of free hemoglobin, and long known to be part of the hepatic acute phase response, perfectly sits in the intersection between obesity and inflammation: it is expressed by adipocytes and its abundance in WAT and in plasma positively relates to the degree of adiposity. In the present review, we will analyze causes and consequences of Hp expression and regulation in WAT and how these relate to the obesity/inflammation paradigm and comorbidities. |
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| AbstractList | Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessive weight gain, becomes infiltrated with macrophages and lymphocytes and undergoes important changes in its gene expression. Haptoglobin (Hp), a typical marker of inflammation in clinical practice, main carrier of free hemoglobin, and long known to be part of the hepatic acute phase response, perfectly sits in the intersection between obesity and inflammationit is expressed by adipocytes and its abundance in WAT and in plasma positively relates to the degree of adiposity. In the present review, we will analyze causes and consequences of Hp expression and regulation in WAT and how these relate to the obesity/inflammation paradigm and comorbidities. Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessive weight gain, becomes infiltrated with macrophages and lymphocytes and undergoes important changes in its gene expression. Haptoglobin (Hp), a typical marker of inflammation in clinical practice, main carrier of free hemoglobin, and long known to be part of the hepatic acute phase response, perfectly sits in the intersection between obesity and inflammation: it is expressed by adipocytes and its abundance in WAT and in plasma positively relates to the degree of adiposity. In the present review, we will analyze causes and consequences of Hp expression and regulation in WAT and how these relate to the obesity/inflammation paradigm and comorbidities. Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessive weight gain, becomes infiltrated with macrophages and lymphocytes and undergoes important changes in its gene expression. Haptoglobin (Hp), a typical marker of inflammation in clinical practice, main carrier of free hemoglobin, and long known to be part of the hepatic acute phase response, perfectly sits in the intersection between obesity and inflammation: it is expressed by adipocytes and its abundance in WAT and in plasma positively relates to the degree of adiposity. In the present review, we will analyze causes and consequences of Hp expression and regulation in WAT and how these relate to the obesity/inflammation paradigm and comorbidities.Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessive weight gain, becomes infiltrated with macrophages and lymphocytes and undergoes important changes in its gene expression. Haptoglobin (Hp), a typical marker of inflammation in clinical practice, main carrier of free hemoglobin, and long known to be part of the hepatic acute phase response, perfectly sits in the intersection between obesity and inflammation: it is expressed by adipocytes and its abundance in WAT and in plasma positively relates to the degree of adiposity. In the present review, we will analyze causes and consequences of Hp expression and regulation in WAT and how these relate to the obesity/inflammation paradigm and comorbidities. |
| Author | Barone, Ilaria Maffei, Margherita Santini, Ferruccio Scabia, Gaia |
| AuthorAffiliation | Institute of Clinical Physiology (M.M.), Italian National Research Council, 56124 Pisa, Italy; Laboratory of Neurobiology (I.B.), Scuola Normale Superiore, 56100 Pisa, Italy; and Obesity Center at the Endocrinology Unit (M.M., I.B., G.S., F.S.), Pisa University-Hospital Department of Clinical and Experimental Medicine, 56124 Pisa, Italy |
| AuthorAffiliation_xml | – name: Institute of Clinical Physiology (M.M.), Italian National Research Council, 56124 Pisa, Italy; Laboratory of Neurobiology (I.B.), Scuola Normale Superiore, 56100 Pisa, Italy; and Obesity Center at the Endocrinology Unit (M.M., I.B., G.S., F.S.), Pisa University-Hospital Department of Clinical and Experimental Medicine, 56124 Pisa, Italy |
| Author_xml | – sequence: 1 givenname: Margherita surname: Maffei fullname: Maffei, Margherita email: m.maffei@ifc.cnr.it organization: 1Institute of Clinical Physiology (M.M.), Italian National Research Council, 56124 Pisa, Italy – sequence: 2 givenname: Ilaria surname: Barone fullname: Barone, Ilaria organization: 2Laboratory of Neurobiology (I.B.), Scuola Normale Superiore, 56100 Pisa, Italy – sequence: 3 givenname: Gaia surname: Scabia fullname: Scabia, Gaia organization: 3Obesity Center at the Endocrinology Unit (M.M., I.B., G.S., F.S.), Pisa University-Hospital Department of Clinical and Experimental Medicine, 56124 Pisa, Italy – sequence: 4 givenname: Ferruccio surname: Santini fullname: Santini, Ferruccio organization: 3Obesity Center at the Endocrinology Unit (M.M., I.B., G.S., F.S.), Pisa University-Hospital Department of Clinical and Experimental Medicine, 56124 Pisa, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27337111$$D View this record in MEDLINE/PubMed |
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| Publisher | Oxford University Press Copyright by The Endocrine Society |
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| SubjectTerms | Adipocytes Adipose tissue Adipose Tissue, White - metabolism Comorbidity Gene expression Haptoglobin Haptoglobins - metabolism Hemoglobin Humans Inflammation Inflammation - blood Inflammation - metabolism Lymphocytes Macrophages Obesity Obesity - blood Obesity - metabolism |
| Title | The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism |
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