TGF‐β limits IL‐33 production and promotes the resolution of colitis through regulation of macrophage function

• Published in: European journal of immunology Vol. 41; no. 7; pp. 2000 - 2009
• Main Authors: Rani, Reena, Smulian, Alan G., Greaves, David R., Hogan, Simon P., Herbert, De'Broski R.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag 01.07.2011
• Subjects: Animals; Antigens, CD - genetics; Antigens, Differentiation, Myelomonocytic - genetics; Blotting, Southern; Colitis - chemically induced; Colitis - immunology; Colitis, Ulcerative - immunology; Dextran Sulfate; Disease Models, Animal; Flow Cytometry; Immunoglobulin E - biosynthesis; Inflammation; Interleukin-33; Interleukins - biosynthesis; Intestine; Macrophages - immunology; Mice; Mice, Transgenic; Mϕs; Promoter Regions, Genetic; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - metabolism; Transforming Growth Factor beta - metabolism

Mϕs promote tissue injury or repair depending on their activation status and the local cytokine milieu. It remains unclear whether the immunosuppressive effects of transforming growth factor β (TGF‐β) serve a nonredundant role in Mϕ function in vivo. We generated Mϕ‐specific transgenic mice that exp...