Cloning and Expression Patterns of two Members of A Novel Protein‐kinase‐C‐related Kinase Family
The cDNA clones for two members of a novel protein kinase family were isolated and sequenced. These protein‐kinase‐C‐related kinases, PRK1 and PRK2, display extensive identity to each other, revealing non‐kinase domain similar regions, HR1 and HR2. HR1 contains a motif repeated three times (HR1a–c),...
Saved in:
| Published in | European journal of biochemistry Vol. 227; no. 1‐2; pp. 344 - 351 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.1995
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The cDNA clones for two members of a novel protein kinase family were isolated and sequenced. These protein‐kinase‐C‐related kinases, PRK1 and PRK2, display extensive identity to each other, revealing non‐kinase domain similar regions, HR1 and HR2. HR1 contains a motif repeated three times (HR1a–c), while HR2 shows similarity to the amino‐terminal sequence of protein‐kinase‐C ɛ and η isotypes. Both PRK1 and PRK2, expressed in COS 1 cells, are autophosphorylated in immunoprecipitates, indicating intrinsic kinase activity. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. |
|---|---|
| AbstractList | The cDNA clones for two members of a novel protein kinase family were isolated and sequenced. These protein-kinase-C-related kinases, PRK1 and PRK2, display extensive identity to each other, revealing non-kinase domain similar regions, HR1 and HR2. HR1 contains a motif repeated three times (HR1a-c), while HR2 shows similarity to the amino-terminal sequence of protein-kinase-C epsilon and eta isotypes. Both PRK1 and PRK2, expressed in COS 1 cells, are autophosphorylated in immunoprecipitates, indicating intrinsic kinase activity. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. The cDNA clones for two members of a novel protein kinase family were isolated and sequenced. These protein‐kinase‐C‐related kinases, PRK1 and PRK2, display extensive identity to each other, revealing non‐kinase domain similar regions, HR1 and HR2. HR1 contains a motif repeated three times (HR1a–c), while HR2 shows similarity to the amino‐terminal sequence of protein‐kinase‐C ɛ and η isotypes. Both PRK1 and PRK2, expressed in COS 1 cells, are autophosphorylated in immunoprecipitates, indicating intrinsic kinase activity. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. |
| Author | Ridden, John Palmer, Ruth H. Parker, Peter J. |
| Author_xml | – sequence: 1 givenname: Ruth H. surname: Palmer fullname: Palmer, Ruth H. – sequence: 2 givenname: John surname: Ridden fullname: Ridden, John – sequence: 3 givenname: Peter J. surname: Parker fullname: Parker, Peter J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7851406$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVUcGO0zAQtdCipbvwCUgWB24pHseOYy5oqVpALLAScLacZIxSErvYKdve-AS-kS_B3VZ7RViyZuz33oz03gU588EjIc-AzSGfF-s5iJIXwMpyDlrL-dRwVua6e0Bm99AZmTEGouBaVo_IRUprxlilK3VOzlUtQbBqRtxiCL7336j1HV3uNhFT6oOnN3aaMPpEg6PTbaAfcGww3j2v6MfwEwd6E8OEvf_z6_f33tuEuVnkG3GwE3b0_d0nXdmxH_aPyUNnh4RPTvWSfF0tvyzeFtef3rxbXF0XrSiFKFBaoUFUGqrOcccV6JZJBapxbWsd1I1mTraSc8saBwxqKzqoM5sDd7UtL8nz49xNDD-2mCYz9qnFYbAewzYZpUDIWsl_EqGqtVC1yMSXR2IbQ0oRndnEfrRxb4CZQxpmbQ6Wm4Pl5pCGOaVhdln89LRl24zY3UtP9mf81RG_7Qfc_8dks1q-_pwdK_8CMZ2ehw |
| CitedBy_id | crossref_primary_10_1006_bbrc_1997_6669 crossref_primary_10_1074_jbc_272_15_10030 crossref_primary_10_1016_j_bbrc_2003_12_148 crossref_primary_10_1016_j_bcp_2013_10_023 crossref_primary_10_1042_BST20200466 crossref_primary_10_1016_0959_440X_95_80103_0 crossref_primary_10_1128_MCB_17_4_2247 crossref_primary_10_1074_jbc_M001753200 crossref_primary_10_1016_S1097_2765_00_80389_5 crossref_primary_10_1046_j_1471_4159_2001_00624_x crossref_primary_10_3390_biom13111599 crossref_primary_10_1111_cmi_12464 crossref_primary_10_1006_bbrc_2001_4909 crossref_primary_10_1016_j_yjmcc_2019_01_029 crossref_primary_10_1016_S0960_9822_02_70678_7 crossref_primary_10_1074_jbc_272_6_3544 crossref_primary_10_1534_genetics_107_072967 crossref_primary_10_1128_MCB_24_9_3957_3971_2004 crossref_primary_10_1007_s00427_003_0325_9 crossref_primary_10_1006_dbio_1997_8791 crossref_primary_10_1016_S0378_1119_00_00365_6 crossref_primary_10_1073_pnas_090491897 crossref_primary_10_1074_jbc_275_20_14824 crossref_primary_10_1615_CritRevImmunol_2023052095 crossref_primary_10_1021_bi401216w crossref_primary_10_1074_jbc_274_8_4551 crossref_primary_10_1074_jbc_271_16_9816 crossref_primary_10_1074_jbc_272_24_15569 crossref_primary_10_1046_j_1365_2958_2002_02925_x crossref_primary_10_1074_jbc_272_47_29449 crossref_primary_10_1016_j_abb_2008_09_008 crossref_primary_10_1016_S0888_7543_03_00072_7 crossref_primary_10_1006_dbio_2000_9943 crossref_primary_10_1074_jbc_272_45_28704 crossref_primary_10_1074_jbc_M407450200 crossref_primary_10_1016_j_celrep_2015_12_049 crossref_primary_10_1074_jbc_M409551200 crossref_primary_10_1016_S0169_328X_99_00273_9 crossref_primary_10_1371_journal_pone_0021732 crossref_primary_10_1074_jbc_273_13_7470 crossref_primary_10_1172_JCI96165 crossref_primary_10_1074_jbc_270_38_22412 crossref_primary_10_1074_jbc_270_48_28495 crossref_primary_10_1038_sj_onc_1208147 crossref_primary_10_1016_0014_5793_95_01454_3 crossref_primary_10_1074_jbc_M109_051151 crossref_primary_10_1128_JVI_01826_14 crossref_primary_10_1111_j_1438_8677_2008_00083_x crossref_primary_10_1074_jbc_271_50_32233 crossref_primary_10_1016_j_abb_2021_108817 crossref_primary_10_1016_j_chom_2016_07_018 crossref_primary_10_1016_j_yexcr_2006_08_028 crossref_primary_10_1074_jbc_275_15_11064 crossref_primary_10_1002_bies_950180703 crossref_primary_10_1186_s12943_017_0747_z crossref_primary_10_1534_g3_114_010579 crossref_primary_10_1016_S0169_328X_98_00155_7 crossref_primary_10_3390_ijms21113818 crossref_primary_10_1002_pro_5560050120 crossref_primary_10_1046_j_1464_6722_2001_00081_x crossref_primary_10_1074_jbc_271_46_28772 crossref_primary_10_1016_j_job_2019_07_002 crossref_primary_10_1152_ajpheart_2000_278_6_H1769 crossref_primary_10_18632_oncotarget_19946 crossref_primary_10_1038_srep29351 crossref_primary_10_1074_jbc_M111_327437 crossref_primary_10_1073_pnas_95_20_11566 crossref_primary_10_1101_gad_855801 crossref_primary_10_1016_S0014_5793_01_02401_2 crossref_primary_10_1074_jbc_M408617200 crossref_primary_10_1074_jbc_M010646200 crossref_primary_10_1096_fasebj_13_13_1658 crossref_primary_10_1016_j_cellsig_2020_109546 crossref_primary_10_1042_BCJ20220281 crossref_primary_10_1002_pro_5560051201 crossref_primary_10_1021_bi200039u crossref_primary_10_1002_1096_9861_20001016_426_2_243__AID_CNE6_3_0_CO_2_8 crossref_primary_10_1074_jbc_M301226200 crossref_primary_10_1006_bbrc_1999_1116 crossref_primary_10_1021_bi010719z crossref_primary_10_1111_jcmm_15943 crossref_primary_10_1016_S0960_9822_99_80186_9 crossref_primary_10_1021_acs_biochem_4c00009 crossref_primary_10_1074_jbc_M003148200 crossref_primary_10_1038_sj_emboj_7601637 crossref_primary_10_1074_jbc_273_5_2698 crossref_primary_10_1515_hsz_2019_0408 crossref_primary_10_1126_science_271_5249_648 crossref_primary_10_1016_S0378_1119_03_00672_3 crossref_primary_10_1126_science_271_5249_645 crossref_primary_10_3390_genes14020247 crossref_primary_10_1074_jbc_M304313200 |
| Cites_doi | 10.1016/0163-7258(91)90042-K 10.1016/0014-5793(92)80934-9 10.1016/S0021-9258(18)53494-3 10.1093/nar/15.20.8125 10.1128/MCB.11.4.2057 10.1006/bbrc.1994.1313 10.1073/pnas.84.2.388 10.1016/0076-6879(91)00169-W 10.1016/S0021-9258(18)45723-7 10.1016/0959-437X(93)90035-N 10.1038/366583a0 10.1016/0003-2697(76)90527-3 10.1016/S0021-9258(17)37580-4 10.1016/S0021-9258(19)36543-3 10.1073/pnas.74.12.5463 10.1016/0968-0004(94)90038-8 10.1016/0092-8674(87)90509-5 10.1111/j.1432-1033.1990.tb19139.x 10.1126/science.1411571 10.1038/366129a0 10.1111/j.1462-5822.2007.00901.x 10.1016/S0021-9258(20)80525-0 10.1016/0014-5793(94)01202-4 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 8FD FR3 P64 RC3 7X8 |
| DOI | 10.1111/j.1432-1033.1995.tb20395.x |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Nucleic Acids Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Engineering Research Database Technology Research Database Nucleic Acids Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | Genetics Abstracts MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1432-1033 |
| EndPage | 351 |
| ExternalDocumentID | 10_1111_j_1432_1033_1995_tb20395_x 7851406 FEBS344 |
| Genre | article Journal Article |
| GroupedDBID | -DZ -~X .55 .GA .GJ .Y3 10A 1OC 24P 29G 31~ 36B 3O- 4.4 51W 51X 52N 52O 52P 52R 52S 52T 52W 52X 53G 5GY 5HH 5LA 5RE 66C 7PT 8-1 8-4 8-5 930 A01 A03 AAEVG AAHHS AAZKR ABDBF ABEFU ABJNI ACCFJ ACFBH ACGFS ACMXC ACNCT ACXQS ADBBV ADIZJ ADZOD AEEZP AEIMD AEQDE AETEA AEUQT AFBPY AFPWT AFZJQ AI. AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR BAWUL BY8 C45 CAG CO8 COF CS3 D-7 D-F DIK E3Z EAD EAP EAS EAU EBB EBC EBD EBS EBX EJD EMB EMK EMOBN EST ESX EX3 F00 F01 F04 F5P G-S G8K GODZA GX1 HZI IH2 IHE IPNFZ L7B LH4 LP6 LP7 LW6 MVM O9- OBS OHT OVD P4B P4D QB0 RIG ROL SDH SUPJJ SV3 TEORI TR2 TUS UB1 VH1 WH7 WOW WQJ WRC WXI X7M XG1 Y6R YFH YSK YUY ZGI ZXP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 8FD FR3 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c4344-e5a49146916df2f2719c05717bfccaf18b90f5c522a0bf1018a4d1816d212f8a3 |
| IEDL.DBID | 24P |
| ISSN | 0014-2956 |
| IngestDate | Fri Aug 16 20:40:09 EDT 2024 Fri Aug 16 21:54:51 EDT 2024 Thu Sep 26 19:34:38 EDT 2024 Sat Sep 28 08:39:14 EDT 2024 Sat Aug 24 00:58:35 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1‐2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4344-e5a49146916df2f2719c05717bfccaf18b90f5c522a0bf1018a4d1816d212f8a3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1995.tb20395.x |
| PMID | 7851406 |
| PQID | 16894784 |
| PQPubID | 23462 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_77145875 proquest_miscellaneous_16894784 crossref_primary_10_1111_j_1432_1033_1995_tb20395_x pubmed_primary_7851406 wiley_primary_10_1111_j_1432_1033_1995_tb20395_x_FEBS344 |
| PublicationCentury | 1900 |
| PublicationDate | January 1995 |
| PublicationDateYYYYMMDD | 1995-01-01 |
| PublicationDate_xml | – month: 01 year: 1995 text: January 1995 |
| PublicationDecade | 1990 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: England |
| PublicationTitle | European journal of biochemistry |
| PublicationTitleAlternate | Eur J Biochem |
| PublicationYear | 1995 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | 1994; 199 1987; 84 1991; 200 1994; 269 1987; 50 1994; 19 1991; 11 1976; 72 1992; 312 1992; 258 1991; 51 1977; 74 1990; 191 1994 1993; 268 1993; 366 1990; 265 1970; 227 1993; 3 1989 1987; 15 e_1_2_2_3_2 e_1_2_2_24_2 e_1_2_2_4_2 e_1_2_2_23_2 e_1_2_2_5_2 e_1_2_2_11_2 e_1_2_2_22_2 e_1_2_2_6_2 e_1_2_2_21_2 Baier G. (e_1_2_2_12_2) 1993; 268 e_1_2_2_20_2 e_1_2_2_2_2 Selbie L. A. (e_1_2_2_13_2) 1993; 268 e_1_2_2_18_2 e_1_2_2_7_2 e_1_2_2_8_2 e_1_2_2_17_2 Sambrook J. (e_1_2_2_19_2) 1989 e_1_2_2_16_2 e_1_2_2_15_2 e_1_2_2_9_2 Osada S. (e_1_2_2_10_2) 1990; 265 Dekker L. V. (e_1_2_2_25_2) 1993; 268 Johannes F. J. (e_1_2_2_14_2) 1994; 269 |
| References_xml | – volume: 265 start-page: 22434 year: 1990 end-page: 22440 article-title: A phorbol ester receptor/protein kinase, nPKCη, a new member of the protein‐kinase‐C family predominantly expressed in lung and skin publication-title: J. Biol. Chem. – volume: 269 start-page: 6140 year: 1994 end-page: 6148 article-title: PKCu is a novel, atypical member of the protein‐kinase‐C family publication-title: J. Biol. Chem. – volume: 15 start-page: 8125 year: 1987 end-page: 8148 article-title: An Analysis of 5′‐noncoding sequences from 699 vertebrate messenger RNAs publication-title: Nucleic Acids Res. – volume: 366 start-page: 129 year: 1993 end-page: 135 article-title: The protein‐tyrosine kinase jak1 complements defects in interferon‐alpha/beta and interferon‐gamma signal‐transduction publication-title: Nature – volume: 200 start-page: 533 year: 1991 end-page: 546 article-title: Cloning members of protein‐tyrosine kinase family using polymerase chain‐reaction publication-title: Methods Enzymol. – volume: 258 start-page: 607 year: 1992 end-page: 614 article-title: Intracellular signalling by hydrolysis of phospholipids and activation of protein‐kinase‐C publication-title: Science – volume: 72 start-page: 248 year: 1976 end-page: 254 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‐dye binding publication-title: Anal. Biochem. – volume: 199 start-page: 897 year: 1994 end-page: 904 article-title: A novel protein kinase with leucine zipper‐like sequences: its catalytic domain is highly homologous to that of protein‐kinase‐C publication-title: Biochem. Biophys. Res. Commun. – volume: 11 start-page: 2057 year: 1991 end-page: 2065 article-title: 2 novel protein‐tyrosine kinases, each with a 2nd phosphotransferase‐related catalytic domain, define a new class of protein‐kinase publication-title: Mol. Cell. Biol. – volume: 366 start-page: 583 year: 1993 end-page: 585 article-title: Interferon‐induced nuclear signaling by jak protein‐tyrosine kinases publication-title: Nature – year: 1989 – volume: 191 start-page: 431 year: 1990 end-page: 435 article-title: Proteolytic activation of protein‐kinase‐C‐ε publication-title: Eur. J. Biochem. – volume: 84 start-page: 388 year: 1987 article-title: Homology probing – identification of cDNA clones encoding members of the protein‐serine kinase family publication-title: Proc. Natl Acad. Sci. USA – volume: 268 start-page: 4997 year: 1993 end-page: 5004 article-title: Molecular‐cloning and characterization of pkc‐theta, a novel nmember of protein‐kinase‐c (pkc) gene family expressed predominantly in hematopoietic‐cells publication-title: J. Biol. Chem. – volume: 51 start-page: 71 year: 1991 end-page: 95 article-title: Protein‐kinase‐C publication-title: Pharm. Therap. – volume: 50 start-page: 823 year: 1987 article-title: A 1001 protein‐kinases publication-title: Cell – volume: 3 start-page: 278 year: 1993 end-page: 285 article-title: Interactions of coiled coils in transcription factors: where is the specificity? publication-title: Curr. Opin. Genet. Dev. – volume: 268 start-page: 24296 year: 1993 end-page: 24302 article-title: Molecular‐cloning and characterization of PKC(iota), an atypical isoform of protein‐kinase‐C derived from insulin‐secreting cells publication-title: J. Biol. Chem. – year: 1994 – volume: 227 start-page: 680 year: 1970 end-page: 685 article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4 publication-title: Nature – volume: 312 start-page: 195 year: 1992 end-page: 199 article-title: Biochemical properties of rat protein‐kinase‐C‐η expressed in COS cells publication-title: FEBS Lett. – volume: 268 start-page: 19498 year: 1993 end-page: 19504 article-title: Mutagenesis of the regulatory domain of rat protein C‐η a molecular basis for restricted histone kinase activity publication-title: J. Biol. Chem. – volume: 74 start-page: 5463 year: 1977 end-page: 5467 article-title: DNA sequencing with chain‐terminating inhibitors publication-title: Proc. Natl Acad. Sci. USA – volume: 19 start-page: 73 year: 1994 end-page: 77 article-title: Protein‐kinase‐C – a question of specificity publication-title: Trends Biochem. Sci. – ident: e_1_2_2_9_2 doi: 10.1016/0163-7258(91)90042-K – ident: e_1_2_2_11_2 doi: 10.1016/0014-5793(92)80934-9 – volume: 268 start-page: 4997 year: 1993 ident: e_1_2_2_12_2 article-title: Molecular‐cloning and characterization of pkc‐theta, a novel nmember of protein‐kinase‐c (pkc) gene family expressed predominantly in hematopoietic‐cells publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)53494-3 contributor: fullname: Baier G. – volume-title: Molecular cloning: a laboratory manual year: 1989 ident: e_1_2_2_19_2 contributor: fullname: Sambrook J. – ident: e_1_2_2_20_2 doi: 10.1093/nar/15.20.8125 – ident: e_1_2_2_4_2 doi: 10.1128/MCB.11.4.2057 – ident: e_1_2_2_22_2 doi: 10.1006/bbrc.1994.1313 – ident: e_1_2_2_3_2 doi: 10.1073/pnas.84.2.388 – ident: e_1_2_2_5_2 doi: 10.1016/0076-6879(91)00169-W – volume: 265 start-page: 22434 year: 1990 ident: e_1_2_2_10_2 article-title: A phorbol ester receptor/protein kinase, nPKCη, a new member of the protein‐kinase‐C family predominantly expressed in lung and skin publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)45723-7 contributor: fullname: Osada S. – ident: e_1_2_2_21_2 doi: 10.1016/0959-437X(93)90035-N – ident: e_1_2_2_7_2 doi: 10.1038/366583a0 – ident: e_1_2_2_18_2 doi: 10.1016/0003-2697(76)90527-3 – volume: 269 start-page: 6140 year: 1994 ident: e_1_2_2_14_2 article-title: PKCu is a novel, atypical member of the protein‐kinase‐C family publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)37580-4 contributor: fullname: Johannes F. J. – volume: 268 start-page: 19498 year: 1993 ident: e_1_2_2_25_2 article-title: Mutagenesis of the regulatory domain of rat protein C‐η a molecular basis for restricted histone kinase activity publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)36543-3 contributor: fullname: Dekker L. V. – ident: e_1_2_2_16_2 doi: 10.1073/pnas.74.12.5463 – ident: e_1_2_2_23_2 doi: 10.1016/0968-0004(94)90038-8 – ident: e_1_2_2_2_2 doi: 10.1016/0092-8674(87)90509-5 – ident: e_1_2_2_24_2 doi: 10.1111/j.1432-1033.1990.tb19139.x – ident: e_1_2_2_8_2 doi: 10.1126/science.1411571 – ident: e_1_2_2_6_2 doi: 10.1038/366129a0 – ident: e_1_2_2_17_2 doi: 10.1111/j.1462-5822.2007.00901.x – volume: 268 start-page: 24296 year: 1993 ident: e_1_2_2_13_2 article-title: Molecular‐cloning and characterization of PKC(iota), an atypical isoform of protein‐kinase‐C derived from insulin‐secreting cells publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(20)80525-0 contributor: fullname: Selbie L. A. – ident: e_1_2_2_15_2 doi: 10.1016/0014-5793(94)01202-4 |
| SSID | ssj0006967 |
| Score | 1.655145 |
| Snippet | The cDNA clones for two members of a novel protein kinase family were isolated and sequenced. These protein‐kinase‐C‐related kinases, PRK1 and PRK2, display... The cDNA clones for two members of a novel protein kinase family were isolated and sequenced. These protein-kinase-C-related kinases, PRK1 and PRK2, display... |
| SourceID | proquest crossref pubmed wiley |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 344 |
| SubjectTerms | Amino Acid Sequence Animals Base Sequence Cell Line Cloning, Molecular DNA, Complementary Humans Molecular Sequence Data Phosphorylation Protein kinase protein kinase C Protein Kinase C - genetics protein‐kinase‐C‐related kinase RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid |
| Title | Cloning and Expression Patterns of two Members of A Novel Protein‐kinase‐C‐related Kinase Family |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1432-1033.1995.tb20395.x https://www.ncbi.nlm.nih.gov/pubmed/7851406 https://search.proquest.com/docview/16894784 https://search.proquest.com/docview/77145875 |
| Volume | 227 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LThsxFLUqWMCmAtKoAVq8QN0Nil9jzzKNEiEQUaQWKTvLM7YlVOpBJLx2fALfyJdw7ZlEhYpFuxjNQ_OSz9j33Du-5yJ0aJ0klcttZqiowEFxJDM8LzOliONOUmVdDA2cTfLjc34yE7M2PTrmwjT6EKuAW-wZabyOHdyU8zednFEYRhiLKXfiaFHSPoM1MMp14DkqfuOUT1fjcl7kjYIm4RkFt6CVIG3n9bxzr9fm6i8O-prSJps03kIfWzKJBw362-iDCzuoMwjgSP9-wN9wmt6Z4uY7aGO4LO3WQX54maKw2ASLR_ftXNiAp0lsM8xx7fHirsZnLpYLSbsDPKlv3SWeRl2Hi_D8-PTrIoAFhI0hLCklxll8mg7ippzGJ3Q-Hv0cHmdtwYWs4ozzzAnDCxg6gTJaTz2VpKiAzxFZegDaE1UWfS8qoGymX_qo9WW4BYqQWzCAXhnWRWuhDu4zwt5KaoSoeHRYSCEMq_qWKRHFb4wtWA-xZbvqq0ZXQ__pjzCqIxo6oqFbNPR9Dx0sIdDQZPHfhgmuvplrkquCS8XfP0NKwgV4Zz3UbbBbPVcC6wRe00MqYfkP76PHo-8_oOV2___SPbTZZMnHqM4-Wltc37gvwHMW5df0-b4AhX7zHA |
| link.rule.ids | 315,786,790,11589,27955,27956,46085,46509 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5V5VAuqLRULK_6gLgFrV-xc1xWu1pod7USrdSb5cS2VNE6iG5LufET-I38EsZOdkVBPcAhykN5yV_s-Wbi-QbgtfOKNr50hWWyQQfF08KKsi60pl54xbTzKTQwX5SzU_HhTJ5twXydC9PpQ2wCbqln5PE6dfAUkP6jl3OG4wjnKedOvl3VbMhxjZTygUjKcEnoWSw3A3NZlZ2EJhUFQ7-g1yDtJ_bcc6-79uovEnqX02ajNN2FRz2bJKMO_sew5eMe7I8ietKX38gbkud35sD5HuyM17Xd9iGML3IYltjoyOS2nwwbyTKrbcYr0gay-tqSuU_1QvLuiCzaG39BlknY4Tz-_P7j03lEE4gbY1xyTox35CgfJF09jSdwOp2cjGdFX3GhaAQXovDSigrHTuSMLrDAFK0aJHRU1QGRDlTX1TDIBjmbHdYhiX1Z4ZAjlA4tYNCWH8B2bKN_CiQ4xayUjUgeC62k5c3QcS2T-o11FR8AX7er-dwJa5jfHRLOTELDJDRMj4a5HcDhGgKDTZZ-btjo2-srQ0tdCaXF_WcoRYVE92wABx12m-cqpJ1IbAagM5b_8D5mOnn3EVvu2f9fegg7s5P5sTl-vzh6Dg-7lPkU4nkB26sv1_4lkp5V_Sp_yr8Ao5z2hA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRQIuCFoqFmjrA-KWav2KneOy7Kql7WolWqk3y4ltqaI4Fd1CufET-I38EsZOdkWLeoBDlIfykr_Y883E8w3AG-cVbXzpCstkgw6Kp4UVZV1oTb3wimnnU2jgeFbun4oPZ_KsT49OuTCdPsQq4JZ6Rh6vUwe_dOFOJ-cMhxHOU8qd3FvUbMhxjYzygSiRSiSdZzFfjctlVXYKmlQUDN2CXoK0n9dzz71um6u_OOhtSptt0vQpPOnJJBl16D-DNR83YHMU0ZH-_J28JXl6Z46bb8Cj8bK02yaE8UWOwhIbHZnc9HNhI5lnsc14RdpAFt9acuxTuZC8OyKz9qu_IPOk63Aef_34-ek8ogXEjTEuOSXGO3KYD5KunMZzOJ1OTsb7RV9woWgEF6Lw0ooKh06kjC6wwBStGuRzVNUBgQ5U19UwyAYpmx3WIWl9WeGQIpQODWDQlm_BemyjfwEkOMWslI1IDgutpOXN0HEtk_iNdRUfAF-2q7nsdDXMn_4IZyahYRIapkfD3AxgdwmBwSZL_zZs9O31laGlroTS4v4zlKJConc2gK0Ou9VzFbJO5DUD0BnLf3gfM528-4gt9_L_L92Fh_P3U3N0MDt8BY-7hPkU4HkN64sv134bKc-i3slf8m8bUPWt |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cloning+and+expression+patterns+of+two+members+of+a+novel+protein-kinase-C-related+kinase+family&rft.jtitle=European+journal+of+biochemistry&rft.au=Palmer%2C+R+H&rft.au=Ridden%2C+J&rft.au=Parker%2C+P+J&rft.date=1995-01-01&rft.issn=0014-2956&rft.volume=227&rft.issue=1-2&rft.spage=344&rft_id=info:doi/10.1111%2Fj.1432-1033.1995.tb20395.x&rft_id=info%3Apmid%2F7851406&rft.externalDocID=7851406 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-2956&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-2956&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-2956&client=summon |