The inducible nitric oxide synthase is impaired by thrombin in vascular smooth muscle cells

• Published in: Journal of cardiovascular pharmacology Vol. 20 Suppl 12; p. S142
• Main Authors: Schini, V B, Catovsky, S, Scott-Burden, T, Vanhoutte, P M
• Format: Journal Article
• Language: English
• Published: United States 01.01.1992
• Subjects: Amino Acid Oxidoreductases - antagonists & inhibitors; Amino Acid Oxidoreductases - biosynthesis; Animals; Aorta; Arginine - analogs & derivatives; Arginine - pharmacology; Cells, Cultured; Enzyme Induction; Hirudins - pharmacology; Interleukin-1 - pharmacology; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - enzymology; Nitric Oxide Synthase; Nitroarginine; Phenylephrine - pharmacology; Rats; Thrombin - pharmacology; Vasodilation - drug effects

The present study investigated whether or not thrombin may affect the induction of nitric oxide (NO) synthase caused by interleukin-1 beta in cultured smooth muscle cells (SMCs) from the rat aorta. The release of nitrite, an oxidation product of NO, from interleukin-1 beta-activated SMCs was inhibit...