Abdominal Adhesion Prevention: Still a Sticky Subject

Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date...

Full description

Saved in:
Bibliographic Details
Published inDigestive surgery Vol. 27; no. 5; pp. 347 - 358
Main Authors Lauder, Chris I.W., Garcea, Giuseppe, Strickland, Andrew, Maddern, Guy J.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.11.2010
Subjects
Online AccessGet full text
ISSN0253-4886
1421-9883
1421-9883
DOI10.1159/000314805

Cover

Loading…
Abstract Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk. Design: Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success. Results: Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation. Conclusions: No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.
AbstractList Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk.BACKGROUNDAdhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk.Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success.DESIGNReview of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success.Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation.RESULTSAdvances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation.No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.CONCLUSIONSNo single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.
Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk. Design: Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success. Results: Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation. Conclusions: No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.
Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk. Design: Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success. Results: Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation. Conclusions: No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result. Copyright © 2010 S. Karger AG, Basel [PUBLICATION ABSTRACT]
Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk. Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success. Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation. No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.
Author Lauder, Chris I.W.
Strickland, Andrew
Garcea, Giuseppe
Maddern, Guy J.
Author_xml – sequence: 1
  givenname: Chris I.W.
  surname: Lauder
  fullname: Lauder, Chris I.W.
– sequence: 2
  givenname: Giuseppe
  surname: Garcea
  fullname: Garcea, Giuseppe
– sequence: 3
  givenname: Andrew
  surname: Strickland
  fullname: Strickland, Andrew
– sequence: 4
  givenname: Guy J.
  surname: Maddern
  fullname: Maddern, Guy J.
  email: guy.maddern@adelaide.edu.au
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20847564$$D View this record in MEDLINE/PubMed
BookMark eNpt0ElLw0AUB_BBKnbRg3eR4EU8xM6aTLyV4gYFhep5mFXTpkmdSYR-exO6HIqn_4P5vce8NwS9siotAJcI3iPEsjGEkCDKITsBA0QxijPOSQ8MIGYkppwnfTAMYdGxJENnoI8hpylL6ACwiTLVKi9lEU3Mtw15VUbv3v7asm7Lh2he50URyS71chPNG7Wwuj4Hp04WwV7scgQ-nx4_pi_x7O35dTqZxZoSUsfOGUKM4o6jtE3lkDOJZixhUKZEGogzqDiGhGpEs1Sl0DjFre2WcjrjZARut3PXvvppbKjFKg_aFoUsbdUEwRFGhGSYtvLmSC6qxrdrdSihGKYkbdH1DjVqZY1Y-3wl_Ubsz9GC8RZoX4XgrRM6r2V3idrLvBAIiu5v4nDwtuPuqGM_9D97tbVL6b-sP8jd8x_-bIWU
CitedBy_id crossref_primary_10_1002_term_3249
crossref_primary_10_1021_acsomega_4c04577
crossref_primary_10_3390_biom11071027
crossref_primary_10_52054_FVVO_15_4_108
crossref_primary_10_1016_j_bioactmat_2023_02_026
crossref_primary_10_1590_s0102_865020180090000011
crossref_primary_10_1007_s00464_023_10432_z
crossref_primary_10_1007_s11605_011_1709_1
crossref_primary_10_1177_08839115231218732
crossref_primary_10_1155_2012_194723
crossref_primary_10_1155_2011_606718
crossref_primary_10_23902_trkjnat_1309119
crossref_primary_10_1007_s13233_013_1163_x
crossref_primary_10_1039_C6TB01376G
crossref_primary_10_1002_btm2_10565
crossref_primary_10_1007_s40005_024_00704_8
crossref_primary_10_3748_wjg_v24_i19_2108
crossref_primary_10_1002_adtp_202000242
crossref_primary_10_1155_2014_279730
crossref_primary_10_1021_acs_chemrev_0c01177
crossref_primary_10_1021_acsbiomaterials_8b00387
crossref_primary_10_1097_TA_0000000000004195
crossref_primary_10_1177_0883911516637374
crossref_primary_10_1177_1934578X19850713
crossref_primary_10_3390_biomedicines9080867
crossref_primary_10_1038_s41467_021_22536_y
crossref_primary_10_3390_ijms131012224
crossref_primary_10_1089_ten_teb_2019_0245
crossref_primary_10_1111_jocs_16062
crossref_primary_10_1067_j_cpsurg_2012_06_005
crossref_primary_10_1124_jpet_114_212795
crossref_primary_10_18499_2070_478X_2024_17_3_120_126
crossref_primary_10_1002_term_3263
crossref_primary_10_1007_s00580_018_2667_8
crossref_primary_10_1038_s41551_019_0442_z
crossref_primary_10_1007_s44174_024_00236_7
crossref_primary_10_3390_gels9020098
crossref_primary_10_1016_j_surg_2015_02_004
crossref_primary_10_1016_j_ijso_2020_05_009
crossref_primary_10_1016_j_progpolymsci_2014_10_004
crossref_primary_10_1016_S0140_6736_13_62002_4
crossref_primary_10_1111_1744_1633_12120
crossref_primary_10_1111_ans_14879
crossref_primary_10_1007_s10570_019_02857_4
crossref_primary_10_1016_j_ijbiomac_2018_07_180
crossref_primary_10_1038_s41467_024_52753_0
crossref_primary_10_5604_01_3001_0016_2730
crossref_primary_10_1371_journal_pone_0049673
crossref_primary_10_1007_s10856_012_4689_0
crossref_primary_10_1002_adfm_202414419
crossref_primary_10_1016_j_jss_2014_03_077
crossref_primary_10_1155_2016_7610387
crossref_primary_10_2174_1570180820666230417100810
Cites_doi 10.1111%2Fj.1445-2197.2009.04880.x
10.1016%2FS0015-0282%2898%2900057-0
10.1016%2Fj.jss.2005.09.032
10.1007%2Fs00464-006-9157-9
10.1016%2FS0002-9378%2898%2970016-X
10.1111%2Fj.1524-475X.2008.00378.x
10.1007%2Fs10350-007-9181-4
10.1093%2Fhumrep%2F13.5.1194
10.1097%2FSLE.0b013e3181886ff4
10.1097%2F00000658-196604000-00011
10.1016%2FS1074-3804%2805%2960257-5
10.1016%2FS0015-0282%2898%2900270-2
10.1097%2F01.sla.0000251519.49405.55
10.1021%2Fbm034130m
10.1159%2F000292042
10.1006%2Fjsre.1998.5317
10.1111%2Fj.1538-7836.2006.02067.x
10.1006%2Fjsre.1995.1236
10.1159%2F000018609
10.1002%2Fbjs.6446
10.1007%2Fs10350-004-0748-z
10.1016%2FS0015-0282%2897%2900574-8
10.1093%2Fhumrep%2F16.8.1732
10.1016%2Fj.fertnstert.2007.05.009
10.1007%2Fs10350-004-0954-8
10.1016%2Fj.surg.2003.07.005
10.1002%2Flsm.1900030103
10.1111%2Fj.1463-1318.2007.01360.x
10.1097%2FSLA.0b013e3181656ce9
10.1001%2Farchsurg.139.7.739
10.1006%2Fjsre.1996.0355
10.1007%2Fs10350-004-6716-9
10.1111%2Fj.1445-1433.2004.03261.x
10.1016%2F0167-5699%2891%2990107-5
10.1007%2Fs004649900887
10.1046%2Fj.1524-475X.1994.20306.x
10.1016%2Fj.ijsu.2008.08.004
10.1093%2Fhumrep%2F15.8.1758
10.1016%2FS1072-7515%2897%2900127-0
10.1006%2Fjsre.1994.1011
10.1046%2Fj.1365-2168.1998.00718.x
10.1016%2FS0002-9378%2898%2970428-4
10.1097%2F01.sla.0000239619.93579.ca
10.1016%2Fj.surg.2006.01.020
10.1093%2Fhumupd%2F7.6.556
10.1016%2Fj.amjsurg.2003.11.014
10.1080%2F10903120701205893
10.1093%2Fhumrep%2Fdeg481
10.1016%2Fj.jamcollsurg.2005.02.034
10.1006%2Fjsre.1996.0081
10.1016%2FS0015-0282%2897%2900573-6
10.1016%2Fj.biomaterials.2008.07.034
10.1016%2Fj.fertnstert.2008.01.052
10.1016%2FS0015-0282%2803%2900759-3
10.1007%2Fs10350-004-6739-2
10.1007%2Fs00384-003-0489-9
10.1007%2FBF02237441
10.1097%2F00000658-200202000-00006
10.1097%2F00006254-199306000-00001
10.1016%2F0022-4804%2884%2990076-3
10.1046%2Fj.1365-2168.2000.01394.x
10.1007%2FBF02237135
10.1097%2F01.sla.0000207837.71831.a2
10.1007%2Fs10350-004-0741-6
10.1006%2Fjsre.2000.6059
10.1381%2F0960892052993530
10.1016%2FS1071-5576%2899%2900007-6
10.1016%2Fj.fertnstert.2004.09.038
10.1097%2F00000658-200108000-00016
10.3109%2F00016348509155163
10.1016%2FS0003-3944%2802%2900863-5
10.1615%2FJLongTermEffMedImplants.v13.i5.50
10.1016%2Fj.jvs.2008.01.034
10.1006%2Fjsre.1993.1038
10.1016%2FS0039-6109%2805%2970574-0
10.1007%2Fs00595-005-3061-0
10.1016%2FS1078-5884%2805%2980203-5
10.1007%2FBF02236862
10.1016%2FS0015-0282%2801%2902875-8
10.1016%2FS0002-9610%2801%2900617-1
10.1007%2Fs10350-005-0268-5
10.1093%2Fhumrep%2Fdei182
10.1159%2F000050149
10.1089%2Flap.2008.0366
10.1111%2Fj.1463-1318.2005.00857.x
10.1111%2Fj.1471-0528.2000.tb11083.x
10.1016%2FS0039-6060%2896%2980096-1
10.1185%2F030079908X273426
10.1089%2Fend.1995.9.277
10.1007%2Fs00464-004-0056-7
10.1016%2FS0015-0282%2801%2901954-9
10.1152%2Fajprenal.00313.2004
10.1016%2FS0015-0282%2898%2900116-2
10.1089%2Flap.2006.0028
10.1016%2FS0015-0282%2801%2901964-1
10.1093%2Fhumrep%2F10.1.161
10.1308%2F003588406X114730
10.1093%2Fhumrep%2F17.4.1031
10.1111%2Fj.1463-1318.2007.01358.x
ContentType Journal Article
Copyright 2010 S. Karger AG, Basel
Copyright © 2010 S. Karger AG, Basel.
Copyright (c) 2010 S. Karger AG, Basel
Copyright_xml – notice: 2010 S. Karger AG, Basel
– notice: Copyright © 2010 S. Karger AG, Basel.
– notice: Copyright (c) 2010 S. Karger AG, Basel
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QO
7QP
7X7
7XB
88E
8AO
8FD
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FR3
FYUFA
GHDGH
K9.
M0S
M1P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1159/000314805
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
ProQuest One Community College
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef

Technology Research Database
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1421-9883
EndPage 358
ExternalDocumentID 2207043521
20847564
10_1159_000314805
314805
Genre Journal Article
Review
GroupedDBID ---
.GJ
0R~
0~5
0~B
29G
30W
327
36B
3O.
3V.
4.4
53G
5GY
5RE
7X7
88E
8AO
8FI
8FJ
8UI
AAYIC
ABJNI
ABPAZ
ABUWG
ACGFS
ACIWK
ACPRK
ACPSR
ADAGL
ADBBV
AENEX
AEYAO
AFJJK
AFKRA
AFRAH
AHMBA
ALDHI
ALIPV
ALMA_UNASSIGNED_HOLDINGS
APPQY
AZPMC
BENPR
BPHCQ
BVXVI
C45
CAG
CCPQU
COF
CS3
CYUIP
DU5
E0A
EBS
EJD
EMB
EMOBN
F5P
FB.
FYUFA
HMCUK
HZ~
IY7
KUZGX
M1P
N9A
O1H
O9-
OVD
P2P
PQQKQ
PROAC
PSQYO
RIG
RKO
RXVBD
SV3
TEORI
UJ6
UKHRP
ZGI
AAYXX
ABBTS
ABWCG
ACQXL
AFSIO
AHFRZ
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
CGR
CUY
CVF
ECM
EIF
NPM
7QO
7QP
7XB
8FD
8FK
FR3
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
PUEGO
7X8
ID FETCH-LOGICAL-c433t-ffd33db8f8173dbbf1fd6c55650a73ad0290b82034c1497b70dfb8ee1159fc983
IEDL.DBID 7X7
ISSN 0253-4886
1421-9883
IngestDate Fri Jul 11 05:30:31 EDT 2025
Sat Aug 23 13:27:34 EDT 2025
Mon Jul 21 06:02:19 EDT 2025
Tue Aug 05 12:08:18 EDT 2025
Thu Apr 24 23:01:58 EDT 2025
Thu Aug 29 12:04:40 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Abdominal surgery
Adhesion barrier
Adhesions
Adhesion prevention
Peritoneum
Language English
License Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
https://www.karger.com/Services/SiteLicenses
Copyright © 2010 S. Karger AG, Basel.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c433t-ffd33db8f8173dbbf1fd6c55650a73ad0290b82034c1497b70dfb8ee1159fc983
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://karger.com/dsu/article-pdf/27/5/347/2675256/000314805.pdf
PMID 20847564
PQID 816420737
PQPubID 34180
PageCount 12
ParticipantIDs proquest_miscellaneous_812133924
crossref_citationtrail_10_1159_000314805
proquest_journals_816420737
crossref_primary_10_1159_000314805
karger_primary_314805
pubmed_primary_20847564
PublicationCentury 2000
PublicationDate 2010-11-01
PublicationDateYYYYMMDD 2010-11-01
PublicationDate_xml – month: 11
  year: 2010
  text: 2010-11-01
  day: 01
PublicationDecade 2010
PublicationPlace Basel, Switzerland
PublicationPlace_xml – name: Basel, Switzerland
– name: Switzerland
– name: Basel
PublicationTitle Digestive surgery
PublicationTitleAlternate Dig Surg
PublicationYear 2010
Publisher S. Karger AG
Publisher_xml – name: S. Karger AG
References Flessner MF: The transport barrier in intraperitoneal therapy. Am J Physiol Renal Physiol 2005;288:F433–F442.1569205510.1152%2Fajprenal.00313.2004
Diamond MP: Reduction of de novo postsurgical adhesions by intraoperative precoating with Sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The Sepracoat Adhesion Study Group. Fertil Steril 1998;69:1067–1074.962729410.1016%2FS0015-0282%2898%2900057-0
Fazio VW, Cohen Z, Fleshman JW, et al: Reduction in adhesive small-bowel obstruction by seprafilm ahesion barrier after intestinal resection. Dis Colon Rectum 2006;49:1–11.1632000510.1007%2Fs10350-005-0268-5
Howard FM: The role of laparoscopy in chronic pelvic pain: promise and pitfalls. Obstet Gynecol Surv 1993;48:357–387.832723510.1097%2F00006254-199306000-00001
Garrard CL, Clements RH, Nanney L, et al: Adhesion formation is reduced after laparoscopic surgery. Surg Endosc 1999;13:10–13.986967910.1007%2Fs004649900887
Chowdhury SM, Hubbell JA: Adhesion prevention with ancrod released via a tissue-adherent hydrogel. J Surg Res 1996;61:58–64.876994310.1006%2Fjsre.1996.0081
Cubukcu A, Alponat A, Gonullu N: An experimental study evaluating the effect of Mitomycin C on the prevention of postoperative intraabdominal adhesions. J Surg Res 2001;96:163–166.1126626810.1006%2Fjsre.2000.6059
Steinleitner A, Lambert H, Kazensky C, et al: Poloxamer 407 as an intraperitoneal barrier material for the prevention of postsurgical adhesion formation and reformation in rodent models for reproductive surgery. Obstet Gynecol 1991;77:48–52.1984226
Savel RH, Balasubramanya S, Lasheen S, et al: Beneficial effects of humidified, warmed carbon dioxide insufflation during laparoscopic bariatric surgery: a randomized clinical trial. Obes Surg 2005;15:64–69.1576050010.1381%2F0960892052993530
Guvenal T, Cetin A, Ozdemir H, et al: Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor. Hum Reprod 2001;16:1732–1735.1147397410.1093%2Fhumrep%2F16.8.1732
Zhou J, Elson C, Lee TD: Reduction in postoperative adhesion formation and re-formation after an abdominal operation with the use of N,O-carboxymethyl chitosan. Surgery 2004;135:307–312.1497648110.1016%2Fj.surg.2003.07.005
Liakakos T, Thomakos N, Fine PM, et al: Peritoneal Adhesions: Etiology, Pathophysiology, and Clinical Significance. Dig Surg 2001;18:260–273.1152813310.1159%2F000050149
Montgomery TC, Sharp JB, Bellina JH, et al: Comparative gross and histological study of the effects of scalpel, electric knife, and carbon dioxide laser on skin and uterine incisions in dogs. Lasers Surg Med 1983;3:9–22.663313710.1002%2Flsm.1900030103
Dunn RC, Mohler M: Effect of varying days of tissue plasminogen activator therapy on the prevention of post-surgical adhesions in a rabbit model. J Surg Res 1993;54:242–245.847424010.1006%2Fjsre.1993.1038
Haney AF, Doty E: A barrier composed of chemically cross-linked hyaluronic acid (Incert) reduces postoperative adhesion formation. Fertil Steril 1998;70:145–151.966043710.1016%2FS0015-0282%2898%2900116-2
Nordic Adhesion Prevention Study Group. The efficacy of Interceed (TC7)* for prevention of reformation of postoperative adhesions on ovaries, fallopian tubes, and fimbriae in microsurgical operations for fertility: a multicenter study. Fertil Steril 1995;63:709–714.7890052
Replogle RL, Johnson R, Gross RE: Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. Ann Surg 1966;163:580–588.593501110.1097%2F00000658-196604000-00011
Farley DR, Greenlee SM, Larson DR, et al: Double-blind, prospective, randomized study of warmed, humidified carbon dioxide insufflation vs standard carbon dioxide for patients undergoing laparoscopic cholecystectomy. Arch Surg 2004;139:739–743; discussion 743–744.1524940610.1001%2Farchsurg.139.7.739
Kovacs EJ, DiPietro LA: Fibrogenic cytokines and connective tissue production. FASEB J 1994;8:854–861.7520879
Diamond MP: Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Seprafilm Adhesion Study Group. Fertil Steril 1996;66:904–910.8941053
Hellebrekers BW, Trimbos-Kemper TC, Boesten L, et al: Preoperative predictors of postsurgical adhesion formation and the Prevention of Adhesions with Plasminogen Activator (PAPA-study): results of a clinical pilot study. Fertil Steril 2009;91:1204–1214.1835331410.1016%2Fj.fertnstert.2008.01.052
Höckel M, Ott S, Siemann U, et al: Prevention of peritoneal adhesions in the rat with sustained intraperitoneal dexamethasone delivered by a novel therapeutic system. Ann Chir Gynaecol 1987;76:306–313.3448986
Schäfer M, Krähenb L, Büchler MW: Comparison of adhesion formation in open and laparoscopic surgery. Dig Surg 1998;15:148–152.984557810.1159%2F000018609
Ellis H: Medicolegal consequences of adhesions. Hosp Med 2004;65:348–350.15222210
Filmar S, Jetha N, McComb P, et al: A comparative histologic study on the healing process after tissue transection. II. Carbon dioxide laser and surgical microscissors. Am J Obstet Gynecol 1989;160:1068–1072.2658599
De Leon F, Toledo A, Sanfilippo J, et al: The prevention of adhesion formation by nonsteroidal antiinflammatory drugs: an animal study comparing ibuprofen and indomethacin. Fertil Steril 1984;41:639–642.6705941
Avital S, Bollinger TJ, Wilkinson JD, et al: Preventing intra-abdominal adhesions with polylactic acid film: an animal study. Dis Colon Rectum 2005;48:153–157.1569067310.1007%2Fs10350-004-0748-z
Wiseman DM, Trout JR, Diamond MP: The rates of adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery. Fertil Steril 1998;70:702–711.979710210.1016%2FS0015-0282%2898%2900270-2
Van Der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, et al: Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg 2000;87:467–471.1075974410.1046%2Fj.1365-2168.2000.01394.x
Lucas P, Warejcka D, Young H, et al: Formation of abdominal adhesions is inhibited by antibodies to transforming growth factor-beta1. J Surg Res 1996;65:135–138.890345910.1006%2Fjsre.1996.0355
Beck DE, Ferguson MA, Opelka FG, et al: Effect of previous surgery on abdominal opening time. Dis Colon Rectum 2000;43:1749–1753.1115646210.1007%2FBF02236862
Holtz G: Failure of a nonsteroidal anti-inflammatory agent (ibuprofen) to inhibit peritoneal adhesion reformation after lysis. Fertil Steril 1982;37:582–583.7067855
Hill-West JL, Chowdhury SM, Sawhney AS, et al: Prevention of postoperative adhesions in the rat by in situ photopolymerization of bioresorbable hydrogel barriers. Obstet Gynecol 1994;83:59–64.8272310
Diamond MP, Luciano A, Johns DA, et al: Reduction of postoperative adhesions by N,O-carboxymethylchitosan: a pilot study. Fertil Steril 2003;80:631–636.1296971110.1016%2FS0015-0282%2803%2900759-3
Schreinemacher MH, Emans PJ, Gijbels MJ, et al: Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model. Br J Surg 2009;96:305–313.1922452110.1002%2Fbjs.6446
American Fertility Society. The AFS classification of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Müllerian anomalies and intrauterine adhesions. Fertil Steril 1988;49:944–955.3371491
Johns DA, Ferland R, Dunn R: Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. J Am Assoc Gynecol Laparosc 2003;10:334–338.1456780710.1016%2FS1074-3804%2805%2960257-5
Bellina JH, Hemmings R, Voros JI, et al: Carbon dioxide laser and electrosurgical wound study with an animal model: a comparison of tissue damage and healing patterns in peritoneal tissue. Am J Obstet Gynecol 1984;148:327–334.6421162
Okuyama N, Rodgers KE, Wang CY, et al: Prevention of retrosternal adhesion formation in a rabbit model using bioresorbable films of polyethylene glycol and polylactic acid. J Surg Res 1998;78:118–122.973362810.1006%2Fjsre.1998.5317
Lower AM, Hawthorn RJ, Ellis H, et al: The impact of adhesions on hospital readmissions over ten years after 8,849 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study. BJOG 2000;107:855–862.1090155610.1111%2Fj.1471-0528.2000.tb11083.x
Oncel M, Remzi FH, Senagore AJ, et al: Application of Adcon-P or Seprafilm in consecutive laparotomies using a murine model. Am J Surg 2004;187:304–308.1476932610.1016%2Fj.amjsurg.2003.11.014
Coleman MG, McLain AD, Moran BJ: Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis Colon Rectum 2000;43:1297–1299.1100550110.1007%2FBF02237441
Ray NF, Denton WG, Thamer M, et al: Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg 1998;186:1–9.944959410.1016%2FS1072-7515%2897%2900127-0
Tang CL, Seow-Choen F, Fook-Chong S, et al: Bioresorbable adhesion barrier facilitates early closure of the defunctioning ileostomy after rectal excision: a prospective, randomised trial. Dis Colon Rectum 2003;46:1200–1207.1297296410.1007%2Fs10350-004-6716-9
Rodgers K, Cohn D, Hotovely A, et al: Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models. Fertil Steril 1998;69:403–408.953186610.1016%2FS0015-0282%2897%2900574-8
Adhesion Barrier Study Group. Prevention of postsurgical adhesions by INTERCEED (TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. Fertil Steril 1989;51:933–938.2524407
Hill-West JL, Dunn RC, Hubbell JA: Local release of fibrinolytic agents for adhesion prevention. J Surg Res 1995;59:759–763.853817810.1006%2Fjsre.1995.1236
Maddern GJ: NOTES: progress or marketing? ANZ J Surg 2009;79:318–319.1956650710.1111%2Fj.1445-2197.2009.04880.x
Nishimura K, Nakamura R, diZerega G: Ibuprofen inhibition of postsurgical a
ref57
ref56
ref59
ref58
ref53
ref52
ref55
ref54
ref51
ref50
ref46
ref45
ref48
ref47
ref42
ref41
ref44
ref43
ref49
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref100
ref40
ref35
ref34
ref37
ref36
ref31
ref30
ref33
ref32
ref39
ref38
ref24
ref23
ref26
ref25
ref20
ref22
ref21
ref28
ref27
ref29
ref13
ref12
ref15
ref14
ref97
ref96
ref11
ref99
ref10
ref98
ref17
ref16
ref19
ref18
ref93
ref92
ref95
ref94
ref91
ref90
ref89
ref86
ref85
ref88
ref87
ref82
ref81
ref84
ref83
ref80
ref79
ref78
ref75
ref74
ref77
ref76
ref2
ref1
ref71
ref70
ref73
ref72
ref68
ref67
ref69
ref64
ref63
ref66
ref65
ref60
ref62
ref61
References_xml – reference: Sulaiman H, Gabella G, Davis C, et al: Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Ann Surg 2001;234:256–261.1150507210.1097%2F00000658-200108000-00016
– reference: Lower AM, Hawthorn RJ, Ellis H, et al: The impact of adhesions on hospital readmissions over ten years after 8,849 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study. BJOG 2000;107:855–862.1090155610.1111%2Fj.1471-0528.2000.tb11083.x
– reference: Flessner MF: The transport barrier in intraperitoneal therapy. Am J Physiol Renal Physiol 2005;288:F433–F442.1569205510.1152%2Fajprenal.00313.2004
– reference: Lucas P, Warejcka D, Young H, et al: Formation of abdominal adhesions is inhibited by antibodies to transforming growth factor-beta1. J Surg Res 1996;65:135–138.890345910.1006%2Fjsre.1996.0355
– reference: Gauwerky JF, Heinrich D, Kubli F: Complications of intraperitoneal dextran application for prevention of adhesions. Biol Res Pregnancy Perinatol 1986;7:93–97.2430629
– reference: Cheong YC, Laird SM, Li TC, et al: Peritoneal healing and adhesion formation/reformation. Hum Reprod Update 2001;7:556–566.1172786410.1093%2Fhumupd%2F7.6.556
– reference: Hoshino A, Kawamura YI, Yasuhara M, et al: Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions. J Immunol 2007;178:5296–5304.17404314
– reference: Ellis H: Medicolegal consequences of adhesions. Hosp Med 2004;65:348–350.15222210
– reference: Stovall TG, Elder RF, Ling FW: Predictors of pelvic adhesions. J Reprod Med 1989;34:345–348.2525188
– reference: Diamond MP, Luciano A, Johns DA, et al: Reduction of postoperative adhesions by N,O-carboxymethylchitosan: a pilot study. Fertil Steril 2003;80:631–636.1296971110.1016%2FS0015-0282%2803%2900759-3
– reference: Dunn RC, Mohler M: Effect of varying days of tissue plasminogen activator therapy on the prevention of postsurgical adhesions in a rabbit model. J Surg Res 1993;54:242–245.847424010.1006%2Fjsre.1993.1038
– reference: Kovacs EJ, DiPietro LA: Fibrogenic cytokines and connective tissue production. FASEB J 1994;8:854–861.7520879
– reference: Savel RH, Balasubramanya S, Lasheen S, et al: Beneficial effects of humidified, warmed carbon dioxide insufflation during laparoscopic bariatric surgery: a randomized clinical trial. Obes Surg 2005;15:64–69.1576050010.1381%2F0960892052993530
– reference: Okuyama N, Rodgers KE, Wang CY, et al: Prevention of retrosternal adhesion formation in a rabbit model using bioresorbable films of polyethylene glycol and polylactic acid. J Surg Res 1998;78:118–122.973362810.1006%2Fjsre.1998.5317
– reference: Molinas CR, Mynbaev O, Pauwels A, et al: Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertil Steril 2001;76:560–567.1153248210.1016%2FS0015-0282%2801%2901964-1
– reference: Reid RL, Lie K, Spence JE, et al: Clinical evaluation of the efficacy of heparin-saturated interceed for prevention of adhesion reformation in the pelvic sidewall of the human; in Diamond MP, diZerega GS, Linsky CB, et al (eds): Gynecologic Surgery and Adhesion Prevention. New York, Wiley, 1993, pp 261–264.
– reference: Corson SL, Batzer FR, Gocial B, et al: Intra-observer and inter-observer variability in scoring laparoscopic diagnosis of pelvic adhesions. Hum Reprod 1995;10:161–164.774504810.1093%2Fhumrep%2F10.1.161
– reference: Perlitz Y, Oettinger M, Karam K, et al: Anaphylactic shock during hysteroscopy using Hyskon solution: case report and review of adverse reactions and their treatment. Gynecol Obstet Invest 1996;41:67–69.882188910.1159%2F000292042
– reference: Weaver FA, Lew W, Granke K, et al: A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures. J Vasc Surg 2008;47:1266–1273.1844075410.1016%2Fj.jvs.2008.01.034
– reference: Bellina JH, Hemmings R, Voros JI, et al: Carbon dioxide laser and electrosurgical wound study with an animal model: a comparison of tissue damage and healing patterns in peritoneal tissue. Am J Obstet Gynecol 1984;148:327–334.6421162
– reference: Haney AF, Doty E: A barrier composed of chemically cross-linked hyaluronic acid (Incert) reduces postoperative adhesion formation. Fertil Steril 1998;70:145–151.966043710.1016%2FS0015-0282%2898%2900116-2
– reference: Avsar F, Sahin M, Aksoy F, et al: Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. Am J Surg 2001;181:512–515.1151377510.1016%2FS0002-9610%2801%2900617-1
– reference: Filmar S, Jetha N, McComb P, et al: A comparative histologic study on the healing process after tissue transection. II. Carbon dioxide laser and surgical microscissors. Am J Obstet Gynecol 1989;160:1068–1072.2658599
– reference: Hill-West JL, Dunn RC, Hubbell JA: Local release of fibrinolytic agents for adhesion prevention. J Surg Res 1995;59:759–763.853817810.1006%2Fjsre.1995.1236
– reference: Schäfer M, Krähenb L, Büchler MW: Comparison of adhesion formation in open and laparoscopic surgery. Dig Surg 1998;15:148–152.984557810.1159%2F000018609
– reference: Guvenal T, Cetin A, Ozdemir H, et al: Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor. Hum Reprod 2001;16:1732–1735.1147397410.1093%2Fhumrep%2F16.8.1732
– reference: de la Portilla F, Ynfante I, Bejarano D, et al: Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats. Dis Colon Rectum 2005;47:2157–2161.10.1007%2Fs10350-004-0741-6
– reference: Parker MC, Wilson MS, Menzies D, et al: The SCAR-3 study: 5-year adhesion-related readmission risk following lower abdominal surgical procedures. Colorectal Dis 2005;7:551–558.1623223410.1111%2Fj.1463-1318.2005.00857.x
– reference: Rodgers K, Cohn D, Hotovely A, et al: Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models. Fertil Steril 1998;69:403–408.953186610.1016%2FS0015-0282%2897%2900574-8
– reference: Coleman MG, McLain AD, Moran BJ: Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis Colon Rectum 2000;43:1297–1299.1100550110.1007%2FBF02237441
– reference: Vrijland WW, Tseng LNL, Eijkman HJM, et al: Fewer intraperitoneal adhesions with use of hyaluronic acid-carboxymethylcellulose membrane: a randomised clinical trial. Ann Surg 2002;235:193–199.1180735810.1097%2F00000658-200202000-00006
– reference: Chowdhury SM, Hubbell JA: Adhesion prevention with ancrod released via a tissue-adherent hydrogel. J Surg Res 1996;61:58–64.876994310.1006%2Fjsre.1996.0081
– reference: Montgomery TC, Sharp JB, Bellina JH, et al: Comparative gross and histological study of the effects of scalpel, electric knife, and carbon dioxide laser on skin and uterine incisions in dogs. Lasers Surg Med 1983;3:9–22.663313710.1002%2Flsm.1900030103
– reference: Nishimura K, Nakamura R, diZerega G: Ibuprofen inhibition of postsurgical adhesion formation: a time and dose response biochemical evaluation in rabbits. J Surg Res 1984;36:115–124.669437710.1016%2F0022-4804%2884%2990076-3
– reference: Holtz G: Failure of a nonsteroidal anti-inflammatory agent (ibuprofen) to inhibit peritoneal adhesion reformation after lysis. Fertil Steril 1982;37:582–583.7067855
– reference: Chen MD, Teigen GA, Reynolds HT, et al: Laparoscopy versus laparotomy: an evaluation of adhesion formation after pelvic and paraaortic lymphadenectomy in a porcine model. Am J Obstet Gynecol 1998;178:499–503.953951610.1016%2FS0002-9378%2898%2970428-4
– reference: Hellebrekers BW, Trimbos-Kemper TC, Boesten L, et al: Preoperative predictors of postsurgical adhesion formation and the Prevention of Adhesions with Plasminogen Activator (PAPA-study): results of a clinical pilot study. Fertil Steril 2009;91:1204–1214.1835331410.1016%2Fj.fertnstert.2008.01.052
– reference: Forestier D, Slim K, Joubert-Zakeyh J, et al: Do bipolar scissors increase postoperative adhesions? An experimental double-blind randomized trial. Ann Chir 2002;127:680–684.1265882610.1016%2FS0003-3944%2802%2900863-5
– reference: Marana R, Rizzi M, Muzii L, et al: Correlation between the American Fertility Society classifications of adnexal adhesions and distal tubal occlusion and reproductive outcome in tubal surgery. Fertil Steril 1995;64:924–929.7589635
– reference: Binda MM, Molinas CR, Koninckx PR: Reactive oxygen species and adhesion formation: clinical implications in adhesion prevention. Hum Reprod 2003;18:2503–2507.1464516310.1093%2Fhumrep%2Fdeg481
– reference: Korell M: Reduction of adhesion by INTERCEED Barrier and Gortex Surgical Membrane after laparoscopic myomectomy; presented at ‘Möglichkeiten der Adhäsionsprophylaxe’, Munich, April 1994.
– reference: Becker JM, Dayton MT, Fazio VW, et al: Prevention of postoperative abdominal adhesions by a sodium hyaluronate based bioresorbable membrane: a prospective, randomised, double-blind multicenter study. J Am Coll Surg 1996;183:297–306.8843257
– reference: Gutt CN, Oniu T, Schemmer P, et al: Fewer adhesions induced by laparoscopic surgery? Surg Endosc 2004;18:898–906.1510810510.1007%2Fs00464-004-0056-7
– reference: Wilson MS: Practicalities and costs of adhesions. Colorectal Dis 2007;9(suppl 2):60–65.1782497210.1111%2Fj.1463-1318.2007.01360.x
– reference: Ansaloni L, Catena F, Coccolini F, et al: Peritoneal adhesions to prosthetic materials: An experimental comparative study of treated and untreated polypropylene meshes placed in the abdominal cavity. J Laparoendosc Adv Surg Tech A 2009;19:369–374.1940579910.1089%2Flap.2008.0366
– reference: Haney A, Hesla J, Hurst B, et al: Expanded polytetrafluororethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7+) in preventing adhesions. Fertil Steril 1995;63:1021–1026.7720911
– reference: Howard FM: The role of laparoscopy in chronic pelvic pain: promise and pitfalls. Obstet Gynecol Surv 1993;48:357–387.832723510.1097%2F00006254-199306000-00001
– reference: Avital S, Bollinger TJ, Wilkinson JD, et al: Preventing intra-abdominal adhesions with polylactic acid film: an animal study. Dis Colon Rectum 2005;48:153–157.1569067310.1007%2Fs10350-004-0748-z
– reference: Van Der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, et al: Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg 2000;87:467–471.1075974410.1046%2Fj.1365-2168.2000.01394.x
– reference: Mercorio F, Mercorio A, Di Spiezio Sardo A, et al: Evaluation of ovarian adhesion formation after laparoscopic ovarian drilling by second-look minilaparoscopy. Fertil Steril 2008;89:1229–1233.1768133910.1016%2Fj.fertnstert.2007.05.009
– reference: Jacob BP, Hogle NJ, Durak E, et al: Tissue ingrowth and bowel adhesion formation in an animal comparative study: polypropylene versus Proceed versus Parietex Composite. Surg Endosc 2007;21:629–633.1728536910.1007%2Fs00464-006-9157-9
– reference: Chalela JA, Katzan I, Liebeskind DS, et al: Safety of intra-arterial thrombolysis in the postoperative period. Stroke 2001;32:1365–1369.11387500
– reference: Kumar S, Wong PF, Leaper DJ: Intra-peritoneal prophylactic agents for preventing adhesions and adhesive intestinal obstruction after non-gynaecological abdominal surgery. Cochrane Database Syst Rev 2009;CD005080.
– reference: Flora ED, Wilson TG, Martin IJ, O’Rourke NA, Maddern GJ: A review of natural orifice translumenal endoscopic surgery (NOTES) for intra-abdominal surgery: experimental models, techniques, and applicability to the clinical setting. Ann Surg 2008;247:583–602.1836262110.1097%2FSLA.0b013e3181656ce9
– reference: Cohen Z, Senagore A, Dayton M, et al: Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomised, evaluator-blinded multicenter study. Dis Colon Rectum 2005;48:1130–1139.1586823010.1007%2Fs10350-004-0954-8
– reference: Dunn RC, Mohler M: Effect of varying days of tissue plasminogen activator therapy on the prevention of post-surgical adhesions in a rabbit model. J Surg Res 1993;54:242–245.847424010.1006%2Fjsre.1993.1038
– reference: Kennedy R, Costain DJ, McAlister VC, et al: Prevention of experimental postoperative peritoneal adhesions by N,O-carboxymethyl chitosan. Surgery 1996;120:866–870.890952310.1016%2FS0039-6060%2896%2980096-1
– reference: Thompson JS, DiBaise JK, Iyer KR, et al: Postoperative short bowel syndrome. J Am Coll Surg 2005;201:85–89.1597844810.1016%2Fj.jamcollsurg.2005.02.034
– reference: LeGrand EK, Rodgers KE, Girgis W, et al: Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models. J Surg Res 1994;56:67–71.827777110.1006%2Fjsre.1994.1011
– reference: Milne AA, Murphy WG, Reading SJ, et al: Fibrin sealant reduces suture line bleeding during carotid endarterectomy: a randomised trial. Eur J Vasc Endovasc Surg 1995;10:91–94.763397610.1016%2FS1078-5884%2805%2980203-5
– reference: Molinas CR, Koninckx PR: Hypoxaemia induced by CO2 or helium pneumoperitoneum is a co-factor in adhesion formation in rabbits. Hum Reprod 2000;15:1758–1763.1092009910.1093%2Fhumrep%2F15.8.1758
– reference: Mahdy T, Mohamed G, Elhawary A: Effect of methylene blue on intra-abdominal adhesion formation in rats. Int J Surg 2008;6:452–455.1881813110.1016%2Fj.ijsu.2008.08.004
– reference: Wiseman DM: Possible intergel reaction syndrome (pIRS). Ann Surg 2006;244:630–632.1699837410.1097%2F01.sla.0000239619.93579.ca
– reference: American Fertility Society. The AFS classification of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Müllerian anomalies and intrauterine adhesions. Fertil Steril 1988;49:944–955.3371491
– reference: Garrard CL, Clements RH, Nanney L, et al: Adhesion formation is reduced after laparoscopic surgery. Surg Endosc 1999;13:10–13.986967910.1007%2Fs004649900887
– reference: Liu Y, Li H, Shu XZ, SD, et al: Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions. Fertil Steril 2005;83(suppl 1):1275–1283.1583130210.1016%2Fj.fertnstert.2004.09.038
– reference: Filmar S, Jetha N, McComb P, et al: A comparative histologic study on the healing process after tissue transection. I. Carbon dioxide laser and electromicrosurgery. Am J Obstet Gynecol 1989;160:1062–1067.2658598
– reference: Yu SL, Singh S, Chen HW, et al: Intra-abdominal adhesion formation induces anti-oxidative injury, enhances cell proliferation, and prevents complement-mediated lysis. Wound Repair Regen 2008;16:388–398.1847125710.1111%2Fj.1524-475X.2008.00378.x
– reference: Cubukcu A, Alponat A, Gonullu N: An experimental study evaluating the effect of Mitomycin C on the prevention of postoperative intraabdominal adhesions. J Surg Res 2001;96:163–166.1126626810.1006%2Fjsre.2000.6059
– reference: Johns DB, Keyport GM, Hoehler F, et al: Reduction of postsurgical adhesions with Intergel adhesion prevention solution: a multicenter study of safety and efficacy after conservative gynecologic surgery. Fertil Steril 2001;76:595–604.1153248710.1016%2FS0015-0282%2801%2901954-9
– reference: Sites CK, Jensen BA, Glock JL, et al: Transvaginal ultrasonographic assessment of transvaginal ultrasonographic assessment of Hyskon or lactated Ringer’s solution instillation after laparoscopy: randomized, controlled study. J Ultrasound Med 1997;16:195–199.9166816
– reference: diZerega GS, Verco SJ, Young P, et al: A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Hum Reprod 2002;17:1031–1038.1192540110.1093%2Fhumrep%2F17.4.1031
– reference: Gustafson SB, Fulkerson P, Bildfell R, et al: Chitosan dressing provides hemostasis in swine femoral arterial injury model. Prehosp Emerg Care 2007;11:172–178.1745480310.1080%2F10903120701205893
– reference: Höckel M, Ott S, Siemann U, et al: Prevention of peritoneal adhesions in the rat with sustained intraperitoneal dexamethasone delivered by a novel therapeutic system. Ann Chir Gynaecol 1987;76:306–313.3448986
– reference: Yeo Y, Ito T, Bellas E, et al: In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg 2007;245:819–824.1745717710.1097%2F01.sla.0000251519.49405.55
– reference: Steinleitner A, Lambert H, Kazensky C, et al: Poloxamer 407 as an intraperitoneal barrier material for the prevention of postsurgical adhesion formation and reformation in rodent models for reproductive surgery. Obstet Gynecol 1991;77:48–52.1984226
– reference: Krähenbühl L, Schäfer M, Kuzinkovas V, et al: Experimental study of adhesion formation in open and laparoscopic fundoplication. Br J Surg 1998;85:826–830.966771710.1046%2Fj.1365-2168.1998.00718.x
– reference: Ellis H: The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl 1997;577:5–9.9076446
– reference: Doria C, Fischer CP, Wood CG, et al: Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery. Curr Med Res Opin 2008;24:785–794.1824152510.1185%2F030079908X273426
– reference: Nordic Adhesion Prevention Study Group. The efficacy of Interceed (TC7)* for prevention of reformation of postoperative adhesions on ovaries, fallopian tubes, and fimbriae in microsurgical operations for fertility: a multicenter study. Fertil Steril 1995;63:709–714.7890052
– reference: Zhou J, Elson C, Lee TD: Reduction in postoperative adhesion formation and re-formation after an abdominal operation with the use of N,O-carboxymethyl chitosan. Surgery 2004;135:307–312.1497648110.1016%2Fj.surg.2003.07.005
– reference: Farley DR, Greenlee SM, Larson DR, et al: Double-blind, prospective, randomized study of warmed, humidified carbon dioxide insufflation vs standard carbon dioxide for patients undergoing laparoscopic cholecystectomy. Arch Surg 2004;139:739–743; discussion 743–744.1524940610.1001%2Farchsurg.139.7.739
– reference: van Goor H: Consequences and complications of peritoneal adhesions. Colorectal Dis 2007;9(suppl 2):25–34.1782496710.1111%2Fj.1463-1318.2007.01358.x
– reference: Ong SY, Wu J, Moochhala SM, et al: Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials 2008;29:4323–4332.1870825110.1016%2Fj.biomaterials.2008.07.034
– reference: Replogle RL, Johnson R, Gross RE: Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. Ann Surg 1966;163:580–588.593501110.1097%2F00000658-196604000-00011
– reference: Zeyneloglu HB, Senturk LM, Seli E, et al: The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Hum Reprod 1998;13:1194–1199.964754610.1093%2Fhumrep%2F13.5.1194
– reference: Leach RE, Henry RL: Reduction of postoperative adhesions in the rat uterine horn model with poloxamer 407. Am J Obstet Gynecol 1990;162:1317–1319.2339733
– reference: Sajid MS, Mallick AS, Rimpel J, et al: Effect of heated and humidified carbon dioxide on patients after laparoscopic procedures: a meta-analysis. Surg Laparosc Endosc Percutan Tech 2008;18:539–546.1909865610.1097%2FSLE.0b013e3181886ff4
– reference: Tang CL, Jayne DG, Seow-Choen F, et al: A randomised controlled trial of 0.5% ferric hyaluronate gel (Intergel) in the prevention of adhesions following abdominal surgery. Ann Surg 2006;243:449–455.1655219410.1097%2F01.sla.0000207837.71831.a2
– reference: Wiseman DM, Trout JR, Diamond MP: The rates of adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery. Fertil Steril 1998;70:702–711.979710210.1016%2FS0015-0282%2898%2900270-2
– reference: Wang GJ, Goldthwaite CA Jr, Burks S, et al: Fibrin sealant reduces perioperative blood loss in total hip replacement. J Long Term Eff Med Implants 2003;13:399–411.1464957810.1615%2FJLongTermEffMedImplants.v13.i5.50
– reference: Adhesion Barrier Study Group. Prevention of postsurgical adhesions by INTERCEED (TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. Fertil Steril 1989;51:933–938.2524407
– reference: Hill-West JL, Chowdhury SM, Sawhney AS, et al: Prevention of postoperative adhesions in the rat by in situ photopolymerization of bioresorbable hydrogel barriers. Obstet Gynecol 1994;83:59–64.8272310
– reference: Kusunoki M, Ikeuchi H, Yanagi H, et al: Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomised clinical trial. Surg Today 2005;35:940–945.1624984810.1007%2Fs00595-005-3061-0
– reference: Adhesion Scoring Group. Improvement of interobserver reproducibility of adhesion scoring system. Fertil Steril 1994;62:984–988.7926146
– reference: Portz D, Elkins T, White R, et al: Oxygen free radicals and pelvic adhesions formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. Int J Fertil 1991;36:39–42.1672675
– reference: Beck DE, Cohen Z, Fleshman JW, et al: A prospective, randomised, multicenter, controlled study of the safety of seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum 2003;46:1310–1319.1453066710.1007%2Fs10350-004-6739-2
– reference: Duffy DM, diZerega GS: Adhesion controversies: pelvic pain as a cause of adhesions, crystalloids in preventing them. J Reprod Med 1996;41:19–26.8855072
– reference: Menzies D, Pascual MH, Walz MK, et al: Use of icodextrin 4% solution in the prevention of adhesion formation following general surgery: from the multicentre ARIEL Registry. Ann R Coll Surg Engl 2006;88:375–382.1683485910.1308%2F003588406X114730
– reference: De Leon F, Toledo A, Sanfilippo J, et al: The prevention of adhesion formation by nonsteroidal antiinflammatory drugs: an animal study comparing ibuprofen and indomethacin. Fertil Steril 1984;41:639–642.6705941
– reference: Fazio VW, Cohen Z, Fleshman JW, et al: Reduction in adhesive small-bowel obstruction by seprafilm ahesion barrier after intestinal resection. Dis Colon Rectum 2006;49:1–11.1632000510.1007%2Fs10350-005-0268-5
– reference: Kopernik G, Avinoach E, Grossman Y, et al: The effect of a high partial pressure of carbon dioxide environment on metabolism and immune functions of human peritoneal cells-relevance to carbon dioxide pneumoperitoneum. Am J Obstet Gynecol 1998;179:1503–1510.985558810.1016%2FS0002-9378%2898%2970016-X
– reference: Beck DE, Ferguson MA, Opelka FG, et al: Effect of previous surgery on abdominal opening time. Dis Colon Rectum 2000;43:1749–1753.1115646210.1007%2FBF02236862
– reference: Tjandra JJ, Chan MK: A sprayable hydrogel adhesion barrier facilitates closure of defunctioning loop ileostomy: a randomized trial. Dis Colon Rectum 2008;51:956–960.1821953010.1007%2Fs10350-007-9181-4
– reference: Liakakos T, Thomakos N, Fine PM, et al: Peritoneal Adhesions: Etiology, Pathophysiology, and Clinical Significance. Dig Surg 2001;18:260–273.1152813310.1159%2F000050149
– reference: Beck DE, Opelka FG, Bailey HR, et al: Incidence of small-bowel obstruction and adhesiolysis after open colorectal and general surgery. Dis Colon Rectum 1999;42:241–248; erratum in Dis Colon Rectum 1999;42:578.1021150210.1007%2FBF02237135
– reference: Ray NF, Denton WG, Thamer M, et al: Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg 1998;186:1–9.944959410.1016%2FS1072-7515%2897%2900127-0
– reference: Tang CL, Seow-Choen F, Fook-Chong S, et al: Bioresorbable adhesion barrier facilitates early closure of the defunctioning ileostomy after rectal excision: a prospective, randomised trial. Dis Colon Rectum 2003;46:1200–1207.1297296410.1007%2Fs10350-004-6716-9
– reference: Zhang ZL, Xu SW, Zhou XL: Preventive effects of chitosan on peritoneal adhesion in rats. World J Gastroenterol 2006;12:4572–4577.16874876
– reference: Holmdahl LE, Al-Jabreen M, Risberg B: Role of fibrinolysis in the formation of postoperative adhesions. Wound Repair Regen 1994;2:171–176.1715610810.1046%2Fj.1524-475X.1994.20306.x
– reference: Maddern GJ: NOTES: progress or marketing? ANZ J Surg 2009;79:318–319.1956650710.1111%2Fj.1445-2197.2009.04880.x
– reference: Kovacs EJ: Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today 1991;12:17–23.201504410.1016%2F0167-5699%2891%2990107-5
– reference: Bellón JM, Rodríguez M, García-Honduvilla N, et al: Peritoneal effects of prosthetic meshes used to repair abdominal wall defects: monitoring adhesions by sequential laparoscopy. J Laparoendosc Adv Surg Tech A 2007;17:160–166.1748464110.1089%2Flap.2006.0028
– reference: Moore RG, Partin AW, Adams JB, et al: Adhesion formation after transperitoneal nephrectomy: laparoscopic vs open approach. J Endourol 1995;9:277–280.755027410.1089%2Fend.1995.9.277
– reference: Haney A, Hesla J, Hurst B, et al: Prevention of pelvic side wall adhesion reformation using surgical barriers: expanded polytetrafluororethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7+) (abstract). Fertil Steril 1994;S210:265.
– reference: Schreinemacher MH, Emans PJ, Gijbels MJ, et al: Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model. Br J Surg 2009;96:305–313.1922452110.1002%2Fbjs.6446
– reference: Johns DA, Ferland R, Dunn R: Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. J Am Assoc Gynecol Laparosc 2003;10:334–338.1456780710.1016%2FS1074-3804%2805%2960257-5
– reference: Rosário MT, Ribeiro U Jr, Corbett CE, et al: Does CO2 pneumoperitoneum alter the ultra-structuture of the mesothelium? J Surg Res 2006;133:84–88.1636017510.1016%2Fj.jss.2005.09.032
– reference: Oncel M, Remzi FH, Senagore AJ, et al: Liquid antiadhesive product (Adcon-p) prevents post-operative adhesions within the intra-abdominal organs in a rat model. Int J Colorectal Dis 2003;18:514–517.1282740710.1007%2Fs00384-003-0489-9
– reference: Berkkanoglu M, Zhang L, Ulukus M, et al: Inhibition of chemokines prevents intraperitoneal adhesions in mice. Hum Reprod 2005;20:3047–3052.1600646410.1093%2Fhumrep%2Fdei182
– reference: Levy O, Martinowitz U, Oran A, et al: The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty. A prospective, randomized, multicenter study. J Bone Joint Surg Am 1999;81:1580–1588.10565650
– reference: Chegini N, Kotseos K, Zhao Y, et al: Expression of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertil Steril 2001;76:1212–1219.1173075310.1016%2FS0015-0282%2801%2902875-8
– reference: Leach RE, Burns JW, Dawe EJ, et al: Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel. Fertil Steril 1998;69:415–418.953186910.1016%2FS0015-0282%2897%2900573-6
– reference: Rabea EI, Badawy ME, Stevens CV, et al: Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules 2003;4:1457–1465.1460686810.1021%2Fbm034130m
– reference: Diamond MP: Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Seprafilm Adhesion Study Group. Fertil Steril 1996;66:904–910.8941053
– reference: Linsky CB, Diamond MP, Cunningham T, et al: Adhesion reduction in the rabbit uterine horn model using an absorbable barrier, TC-7. J Reprod Med 1987;32:17–20.3560059
– reference: Cahill RA, Wang JH, Soohkai S, Redmond HP: Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery 2006;140:108–112.1685744810.1016%2Fj.surg.2006.01.020
– reference: Chapman WC, Lockstadt H, Slngla N, et al: Phase 2, randomized, double-blind, placebo-controlled, multicenter clinical evaluation of recombinant human thrombin in multiple surgical indications. J Thromb Haemost 2006;4:2083–2085.1696162110.1111%2Fj.1538-7836.2006.02067.x
– reference: Kucukozkan T, Ersoy B, Uygur D, et al: Prevention of adhesions by sodium chromoglycate, dexamethasone, saline and aprotinin after pelvic surgery. ANZ J Surg 2004;74:1111–1115.1557415610.1111%2Fj.1445-1433.2004.03261.x
– reference: Orita H, Fukasawa M, Girgis W, diZerega GS: Inhibition of postsurgical adhesions in a standardized rabbit model: intraperitoneal treatment with tissue plasminogen activator. Int J Fertil 1991;36:172–177.1678373
– reference: Hulka JF: Adnexal adhesions, a prognostic staging and classification system based on a 5-year survey of fertility surgery results at Chapel Hill, North Carolina. Am J Obstet and Gynecol 1982;144:141–148.6214187
– reference: DeCherney AH, diZerega GS: Clinical problem of intraperitoneal postsurgical adhesion formation following general surgery and the use of adhesion prevention barriers. Surg Clin North Am 1997;77:671–688.919488610.1016%2FS0039-6109%2805%2970574-0
– reference: Larsson B, Lalos O, Marsk L, et al: Effect of intraperitoneal instillation of 32% dextran 70 on postoperative adhesion formation after tubal surgery. Acta Obstet Gynecol Scand 1985;64:437–441.241496610.3109%2F00016348509155163
– reference: Chegini N, Rong H, Bennett B, et al: Peritoneal fluid cytokine and eicosanoid levels and their relation to the incidence of peritoneal adhesion. J Soc Gynecol Investig 1999;6:153–157.1037627210.1016%2FS1071-5576%2899%2900007-6
– reference: Diamond MP: Reduction of de novo postsurgical adhesions by intraoperative precoating with Sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The Sepracoat Adhesion Study Group. Fertil Steril 1998;69:1067–1074.962729410.1016%2FS0015-0282%2898%2900057-0
– reference: Takeuchi H, Kitade M, Kikuchi I, et al: Adhesion prevention effects of fibrin sealants after laparoscopic myomectomy as determined by second look laparoscopy: a prospective randomised, controlled study. J Reprod Med 2005;50:571–577.16220761
– reference: Oncel M, Remzi FH, Senagore AJ, et al: Application of Adcon-P or Seprafilm in consecutive laparotomies using a murine model. Am J Surg 2004;187:304–308.1476932610.1016%2Fj.amjsurg.2003.11.014
– reference: Menzies D, Ellis H: Intestinal obstruction from adhesions – how big is the problem? Ann R Coll Surg Engl 1990;72:60–632301905
– reference: Menzies D, Ellis H: The role of plasminogen activator in adhesion prevention. Surg Gynecol Obstet 1991;172:362–366.1902993
– ident: ref69
  doi: 10.1111%2Fj.1445-2197.2009.04880.x
– ident: ref100
  doi: 10.1016%2FS0015-0282%2898%2900057-0
– ident: ref22
  doi: 10.1016%2Fj.jss.2005.09.032
– ident: ref43
  doi: 10.1007%2Fs00464-006-9157-9
– ident: ref64
  doi: 10.1016%2FS0002-9378%2898%2970016-X
– ident: ref13
  doi: 10.1111%2Fj.1524-475X.2008.00378.x
– ident: ref51
  doi: 10.1007%2Fs10350-007-9181-4
– ident: ref17
  doi: 10.1093%2Fhumrep%2F13.5.1194
– ident: ref65
  doi: 10.1097%2FSLE.0b013e3181886ff4
– ident: ref28
  doi: 10.1097%2F00000658-196604000-00011
– ident: ref47
  doi: 10.1016%2FS1074-3804%2805%2960257-5
– ident: ref78
  doi: 10.1016%2FS0015-0282%2898%2900270-2
– ident: ref35
  doi: 10.1097%2F01.sla.0000251519.49405.55
– ident: ref83
  doi: 10.1021%2Fbm034130m
– ident: ref92
  doi: 10.1159%2F000292042
– ident: ref98
  doi: 10.1006%2Fjsre.1998.5317
– ident: ref57
  doi: 10.1111%2Fj.1538-7836.2006.02067.x
– ident: ref30
  doi: 10.1006%2Fjsre.1995.1236
– ident: ref61
  doi: 10.1159%2F000018609
– ident: ref84
  doi: 10.1002%2Fbjs.6446
– ident: ref40
  doi: 10.1007%2Fs10350-004-0748-z
– ident: ref99
  doi: 10.1016%2FS0015-0282%2897%2900574-8
– ident: ref24
  doi: 10.1093%2Fhumrep%2F16.8.1732
– ident: ref53
  doi: 10.1016%2Fj.fertnstert.2007.05.009
– ident: ref86
  doi: 10.1007%2Fs10350-004-0954-8
– ident: ref38
  doi: 10.1016%2Fj.surg.2003.07.005
– ident: ref54
  doi: 10.1002%2Flsm.1900030103
– ident: ref50
  doi: 10.1111%2Fj.1463-1318.2007.01360.x
– ident: ref68
  doi: 10.1097%2FSLA.0b013e3181656ce9
– ident: ref67
  doi: 10.1001%2Farchsurg.139.7.739
– ident: ref26
  doi: 10.1006%2Fjsre.1996.0355
– ident: ref89
  doi: 10.1007%2Fs10350-004-6716-9
– ident: ref70
  doi: 10.1111%2Fj.1445-1433.2004.03261.x
– ident: ref18
  doi: 10.1016%2F0167-5699%2891%2990107-5
– ident: ref62
  doi: 10.1007%2Fs004649900887
– ident: ref75
  doi: 10.1046%2Fj.1524-475X.1994.20306.x
– ident: ref77
  doi: 10.1016%2Fj.ijsu.2008.08.004
– ident: ref63
  doi: 10.1093%2Fhumrep%2F15.8.1758
– ident: ref2
  doi: 10.1016%2FS1072-7515%2897%2900127-0
– ident: ref23
  doi: 10.1006%2Fjsre.1994.1011
– ident: ref44
  doi: 10.1046%2Fj.1365-2168.1998.00718.x
– ident: ref41
  doi: 10.1016%2FS0002-9378%2898%2970428-4
– ident: ref97
  doi: 10.1097%2F01.sla.0000239619.93579.ca
– ident: ref16
  doi: 10.1016%2Fj.surg.2006.01.020
– ident: ref12
  doi: 10.1093%2Fhumupd%2F7.6.556
– ident: ref37
  doi: 10.1016%2Fj.amjsurg.2003.11.014
– ident: ref82
  doi: 10.1080%2F10903120701205893
– ident: ref72
  doi: 10.1093%2Fhumrep%2Fdeg481
– ident: ref10
  doi: 10.1016%2Fj.jamcollsurg.2005.02.034
– ident: ref29
  doi: 10.1006%2Fjsre.1996.0081
– ident: ref49
  doi: 10.1016%2FS0015-0282%2897%2900573-6
– ident: ref81
  doi: 10.1016%2Fj.biomaterials.2008.07.034
– ident: ref52
  doi: 10.1016%2Fj.fertnstert.2008.01.052
– ident: ref48
  doi: 10.1016%2FS0015-0282%2803%2900759-3
– ident: ref85
  doi: 10.1007%2Fs10350-004-6739-2
– ident: ref36
  doi: 10.1007%2Fs00384-003-0489-9
– ident: ref7
  doi: 10.1007%2FBF02237441
– ident: ref91
  doi: 10.1097%2F00000658-200202000-00006
– ident: ref9
  doi: 10.1097%2F00006254-199306000-00001
– ident: ref71
  doi: 10.1016%2F0022-4804%2884%2990076-3
– ident: ref5
  doi: 10.1046%2Fj.1365-2168.2000.01394.x
– ident: ref3
  doi: 10.1007%2FBF02237135
– ident: ref90
  doi: 10.1097%2F01.sla.0000207837.71831.a2
– ident: ref25
  doi: 10.1007%2Fs10350-004-0741-6
– ident: ref32
  doi: 10.1006%2Fjsre.2000.6059
– ident: ref66
  doi: 10.1381%2F0960892052993530
– ident: ref14
  doi: 10.1016%2FS1071-5576%2899%2900007-6
– ident: ref31
  doi: 10.1016%2Fj.fertnstert.2004.09.038
– ident: ref4
  doi: 10.1097%2F00000658-200108000-00016
– ident: ref95
  doi: 10.3109%2F00016348509155163
– ident: ref55
  doi: 10.1016%2FS0003-3944%2802%2900863-5
– ident: ref59
  doi: 10.1615%2FJLongTermEffMedImplants.v13.i5.50
– ident: ref56
  doi: 10.1016%2Fj.jvs.2008.01.034
– ident: ref74
  doi: 10.1006%2Fjsre.1993.1038
– ident: ref94
  doi: 10.1016%2FS0039-6109%2805%2970574-0
– ident: ref88
  doi: 10.1007%2Fs00595-005-3061-0
– ident: ref73
  doi: 10.1006%2Fjsre.1993.1038
– ident: ref60
  doi: 10.1016%2FS1078-5884%2805%2980203-5
– ident: ref6
  doi: 10.1007%2FBF02236862
– ident: ref15
  doi: 10.1016%2FS0015-0282%2801%2902875-8
– ident: ref27
  doi: 10.1016%2FS0002-9610%2801%2900617-1
– ident: ref87
  doi: 10.1007%2Fs10350-005-0268-5
– ident: ref33
  doi: 10.1093%2Fhumrep%2Fdei182
– ident: ref8
  doi: 10.1159%2F000050149
– ident: ref34
  doi: 10.1089%2Flap.2008.0366
– ident: ref19
  doi: 10.1111%2Fj.1463-1318.2005.00857.x
– ident: ref20
  doi: 10.1111%2Fj.1471-0528.2000.tb11083.x
– ident: ref39
  doi: 10.1016%2FS0039-6060%2896%2980096-1
– ident: ref58
  doi: 10.1185%2F030079908X273426
– ident: ref42
  doi: 10.1089%2Fend.1995.9.277
– ident: ref1
  doi: 10.1007%2Fs00464-004-0056-7
– ident: ref93
  doi: 10.1016%2FS0015-0282%2801%2901954-9
– ident: ref76
  doi: 10.1152%2Fajprenal.00313.2004
– ident: ref96
  doi: 10.1016%2FS0015-0282%2898%2900116-2
– ident: ref45
  doi: 10.1089%2Flap.2006.0028
– ident: ref21
  doi: 10.1016%2FS0015-0282%2801%2901964-1
– ident: ref46
  doi: 10.1093%2Fhumrep%2F10.1.161
– ident: ref79
  doi: 10.1308%2F003588406X114730
– ident: ref80
  doi: 10.1093%2Fhumrep%2F17.4.1031
– ident: ref11
  doi: 10.1111%2Fj.1463-1318.2007.01358.x
SSID ssj0003691
Score 2.173796
SecondaryResourceType review_article
Snippet Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality....
Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an...
SourceID proquest
pubmed
crossref
karger
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 347
SubjectTerms Abdomen - surgery
Animals
Digestive System Surgical Procedures - methods
Humans
Peritoneum - pathology
Peritoneum - surgery
Review
Tissue Adhesions - epidemiology
Tissue Adhesions - physiopathology
Tissue Adhesions - prevention & control
Title Abdominal Adhesion Prevention: Still a Sticky Subject
URI https://karger.com/doi/10.1159/000314805
https://www.ncbi.nlm.nih.gov/pubmed/20847564
https://www.proquest.com/docview/816420737
https://www.proquest.com/docview/812133924
Volume 27
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEB58IV7Et-uqFPHgpdht2iT1IqsoIijiA_ZWmheKS-tj9-C_d6ZNiwf1FGiHQCfTeSST7wM4zKTWimsZuowozAgLQDJlQ5cWcSaUlYMa7Pnmll89JdejdOR7cz59W2XrE2tHbSpNe-THEvP6GO1RnL69h0QaRYernkFjFuYJuYw6usSoq7fQNzeEeXHKQrRT7oGFMIDT_QWGhQCR1v0IRwuv1H398XeyWQedyxVY9tliMGyWdxVmbLkGizf-PHwd-FCZqqblCobm2dLOV9CCMlXlSfAweRmPg4JG_foVoJegbZfTDXi6vHg8vwo9E0KoE8YmoXOGMaOkkwOBo3IDZ7hOMRmLCsEKE8VZpDCWs0RjxSOUiIxT0lr6VqczyTZhrqxKuw1BwgsumeWRdSYpHAYjVQguuNIppjKJ68FRq5Bce5hwYqsY53W5kGZ5p7seHHSibw02xm9CG41WO5H2eb9Vcu5_m8-8W-QeBN1btHc6xChKW01JJMayGqvGHmw1S9NNHEcYalOe7Pw7dR-W6g6A-j7hLsxNPqZ2DxOLidqvzWcf5s8ubu_uvwGzSMm2
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1JS-xAEC50FJ8XcX2OayMKXoKZdNLpCA8ZN8ZlBnGBucX0huKQuIyIP8r_-Kqz4UG9eWpIqvtQXV1VXy_1AWxGXErBJHdMZCnMbC0AToV2TJB4USg0b-XFnrs91rnxT_tBfwQ-qrcw9lpl5RNzR60yaffIdzjm9R7aY7j3-ORY0ih7uFoxaBRWcabf3xCxvfw7OcTp3fK846Prg45Tkgo40qd06BijKFWCG94KsRWmZRSTAeY1bhLSRLle5AoMi9SXCB5CEbrKCK41Zk6RkRGnOO4ojPkUkUwDxvaPeheXteunrKDo8wLq4MpgZSkj7GpfTFCEHpYm71MAHH-w972fv09v8zB3PA1TZX5K2oVBzcCITmdholuewM8BawuV5URgpK3utN1rI1UZqCzdJVfD-8GAJLaVD-8E_ZLd6Nmbh5tfUdMCNNIs1YtAfJYwTjVztVF-YjD8iSRkIRMywOTJN03YrhQSy7IwueXHGMQ5QAmiuNZdEzZq0ceiGsdXQvOFVmuR6vtypeS4XKgvcW1WTSD1X1xh9tgkSXX2akU8BPKIU5vwt5iaemDPxeAeMH_px6HX4U_nunsen5_0zpZhMr9_kL9mXIHG8PlVr2JaMxRrpTERuP1t-_0PP3wG-A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Abdominal+Adhesion+Prevention%3A+Still+a+Sticky+Subject&rft.jtitle=Digestive+surgery&rft.au=Lauder%2C+Chris+I.W.&rft.au=Garcea%2C+Giuseppe&rft.au=Strickland%2C+Andrew&rft.au=Maddern%2C+Guy+J.&rft.date=2010-11-01&rft.issn=0253-4886&rft.eissn=1421-9883&rft.volume=27&rft.issue=5&rft.spage=347&rft.epage=358&rft_id=info:doi/10.1159%2F000314805&rft.externalDBID=n%2Fa&rft.externalDocID=10_1159_000314805
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0253-4886&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0253-4886&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0253-4886&client=summon