Synthesizing individualized aging brains in health and disease with generative models and parallel transport

• Published in: MEDICAL IMAGE ANALYSIS Vol. 105; p. 103669
• Main Authors: Fu, Jingru, Zheng, Yuqi, Dey, Neel, Ferreira, Daniel, Moreno, Rodrigo
• Format: Journal Article Publication
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2025
• Subjects: Aged; Aging - pathology; Algorithms; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Brain - diagnostic imaging; Brain aging; Diffeomorphic registration; Female; Humans; Magnetic Resonance Imaging - methods; Male; Medical image generation; Middle Aged; Parallel transport; Brain aging; Medical image generation; Alzheimer’s disease; Diffeomorphic registration; Parallel transport

Simulating prospective magnetic resonance imaging (MRI) scans from a given individual brain image is challenging, as it requires accounting for canonical changes in aging and/or disease progression while also considering the individual brain’s current status and unique characteristics. While current...