Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron

• Published in: American journal of physiology. Renal physiology Vol. 308; no. 4; pp. F275 - F286
• Main Authors: Mamenko, M, Zaika, O, Boukelmoune, N, O'Neil, R G, Pochynyuk, O
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.02.2015
• Subjects: Animals; Calcium; Calcium - metabolism; Cell growth; Cells; Electrolytes; Epithelial Cells - metabolism; Homeostasis; Humans; Hyperkalemia - metabolism; Hyperkalemia - physiopathology; Kidney diseases; Mechanotransduction, Cellular; Nephrons - metabolism; Nephrons - physiopathology; Osmotic Pressure; Polycystic Kidney Diseases - metabolism; Polycystic Kidney Diseases - physiopathology; Potassium - metabolism; Pressure; Reviews; TRPV Cation Channels - chemistry; TRPV Cation Channels - genetics; TRPV Cation Channels - metabolism; mechanosensitive intracellular Ca2+ concentration signaling; renal potassium excretion; polycystic kidney disease; flow sensitivity; transient receptor potential cation channel subfamily V member 4

Long-standing experimental evidence suggests that epithelial cells in the renal tubule are able to sense osmotic and pressure gradients caused by alterations in ultrafiltrate flow by elevating intracellular Ca(2+) concentration. These responses are viewed as critical regulators of a variety of proce...