A compact DD neutron generator-based NAA system to quantify manganese (Mn) in bone in vivo
A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*109 neutrons s−1 was set up in our lab for this purpose. Optimized settings, inc...
Saved in:
| Published in | Physiological measurement Vol. 35; no. 9; pp. 1899 - 1911 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
IOP Publishing
01.09.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0967-3334 1361-6579 1361-6579 |
| DOI | 10.1088/0967-3334/35/9/1899 |
Cover
| Abstract | A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*109 neutrons s−1 was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R2 = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g−1 dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans. |
|---|---|
| AbstractList | A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*10(9) neutrons s(-1) was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R(2) = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g(-1) dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans. A deuterium-deuterium (DD) neutron generator–based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo . A DD neutron generator with a flux of up to 3*10 9 neutrons/second was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R 2 = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg/g dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans. A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*109 neutrons s−1 was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R2 = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g−1 dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans. A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*10(9) neutrons s(-1) was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R(2) = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g(-1) dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans.A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*10(9) neutrons s(-1) was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R(2) = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g(-1) dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans. A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*10 super(9) neutrons s super(-1) was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic gamma -rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R super(2) = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1,05 mu g g super(-1) dry bone (ppm) with an equivalent dose of 85.4mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 mu Sv. Given the average nonnal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans. |
| Author | Koltick, David Byrne, Patrick Nie, Linda H Liu, Yingzi Wang, Haoyu Zheng, Wei |
| AuthorAffiliation | 2 Physics Department, Purdue University 1 School of Health Sciences, Purdue University |
| AuthorAffiliation_xml | – name: 1 School of Health Sciences, Purdue University – name: 2 Physics Department, Purdue University |
| Author_xml | – sequence: 1 givenname: Yingzi surname: Liu fullname: Liu, Yingzi organization: School of Health Sciences, Purdue University , West Lafayette, IN, USA – sequence: 2 givenname: Patrick surname: Byrne fullname: Byrne, Patrick organization: School of Health Sciences, Purdue University , West Lafayette, IN, USA – sequence: 3 givenname: Haoyu surname: Wang fullname: Wang, Haoyu organization: Purdue University Physics Department, West Lafayette, IN, USA – sequence: 4 givenname: David surname: Koltick fullname: Koltick, David organization: Purdue University Physics Department, West Lafayette, IN, USA – sequence: 5 givenname: Wei surname: Zheng fullname: Zheng, Wei organization: School of Health Sciences, Purdue University , West Lafayette, IN, USA – sequence: 6 givenname: Linda H surname: Nie fullname: Nie, Linda H organization: School of Health Sciences, Purdue University , West Lafayette, IN, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25154883$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUtv1DAUhS1URKeFX4CEvCyLEL9jb5BGfQBSaTewYWM5jjO4Suyp7Yw0_55EU0bAgq6uJZ9zdO79zsBJiMEB8BajDxhJWSMlmopSymrKa1VjqdQLsMJU4ErwRp2A1VFxCs5yfkAIY0n4K3BKOOZMSroCP9bQxnFrbIFXVzC4qaQY4MYFl0yJqWpNdh28W69h3ufiRlgifJxMKL7fw9GEjQkuO3jxNbyHPsB2rrjMnd_F1-Blb4bs3jzNc_D95vrb5efq9v7Tl8v1bWUZpaXqeuGk7YhsOSdIydb2hvaNIJYo23PBbGcx7ggXhndWYo66hs0PKzrX9lTSc_DxkLud2tF11oWSzKC3yY8m7XU0Xv_9E_xPvYk7zaiUjLI54OIpIMXHyeWiR5-tG4Z5tzhljQVnQjFB0PNSziUntBFL6rs_ax37_L79LKAHgU0x5-T6owQjvRDWCz-98NOUa6UXwrNL_eOyvpji47KbH57x1gevj1v9EKcUZi7_dfwCsL65Iw |
| CODEN | PMEAE3 |
| CitedBy_id | crossref_primary_10_1016_j_bbagen_2016_05_023 crossref_primary_10_1007_s12520_023_01884_4 crossref_primary_10_1016_j_apradiso_2025_111712 crossref_primary_10_3233_JAD_150595 crossref_primary_10_3390_molecules26082375 crossref_primary_10_1088_0967_3334_37_5_649 crossref_primary_10_1088_1361_6579_aabe66 crossref_primary_10_1016_j_jtemb_2020_126469 crossref_primary_10_1016_j_neuro_2021_12_005 crossref_primary_10_3390_ma14051222 crossref_primary_10_1016_j_ncl_2020_07_008 crossref_primary_10_1007_s13246_024_01487_w crossref_primary_10_1088_0967_3334_36_10_2057 crossref_primary_10_1002_mp_12797 crossref_primary_10_1088_1361_6579_ab6019 crossref_primary_10_1007_s40572_015_0056_x crossref_primary_10_1177_0884533617702837 crossref_primary_10_1088_1361_6579_abc322 crossref_primary_10_1007_s40572_023_00402_x crossref_primary_10_1088_1361_6579_aa577b crossref_primary_10_1016_j_apradiso_2019_01_030 crossref_primary_10_1016_j_envres_2017_09_016 crossref_primary_10_1088_1361_6579_aaa749 |
| Cites_doi | 10.1088/0031-9155/54/1/002 10.1179/oeh.2003.9.2.153 10.1002/nbm.931 10.1016/j.neuro.2005.11.002 10.1093/rpd/ncr117 10.1289/ehp.1002321 10.1016/S0273-2300(02)00020-X 10.1016/j.jtemb.2012.04.023 10.1016/j.neuro.2010.10.002 10.1007/s12017-009-8108-8 10.1097/01.jom.0000204114.01893.3e 10.1080/15287390600975004 10.1088/0967-3334/34/12/1593 10.1289/ehp.1002192 10.1016/j.neuro.2010.12.014 10.5271/sjweh.1705 10.1021/ac990570l 10.1002/ajim.20737 10.1016/j.neuro.2006.08.005 10.1016/0021-9681(66)90094-4 10.1016/j.neuro.2012.08.011 10.1016/j.taap.2007.03.001 10.1385/CT:5:4:345 10.1016/j.neuro.2011.07.011 10.1016/S0161-813X(03)00082-2 10.1007/s004200050410 10.1093/toxsci/54.2.295 10.1259/bjr.70.840.9505846 |
| ContentType | Journal Article |
| Copyright | 2014 Institute of Physics and Engineering in Medicine |
| Copyright_xml | – notice: 2014 Institute of Physics and Engineering in Medicine |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7QP 5PM |
| DOI | 10.1088/0967-3334/35/9/1899 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Calcium & Calcified Tissue Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Calcium & Calcified Tissue Abstracts |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Calcium & Calcified Tissue Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Engineering Physics |
| DocumentTitleAlternate | A compact DD neutron generator-based NAA system to quantify manganese (Mn) in bone in vivo |
| EISSN | 1361-6579 |
| EndPage | 1911 |
| ExternalDocumentID | PMC4388434 25154883 10_1088_0967_3334_35_9_1899 pmea499965 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIOSH CDC HHS grantid: R21 OH010700 – fundername: NIOSH CDC HHS grantid: R21 OH010044 – fundername: NIOSH CDC HHS grantid: 1R21OH010044 – fundername: NIEHS NIH HHS grantid: R01 ES008146 – fundername: NIEHS NIH HHS grantid: R21 ES024700 |
| GroupedDBID | --- -~X 123 1JI 4.4 53G 5B3 5VS 5ZH 7.M 7.Q AAGCD AAJIO AAJKP AALHV AATNI ABCXL ABHWH ABJNI ABQJV ABVAM ACAFW ACGFS ACHIP AEFHF AENEX AFYNE AKPSB ALMA_UNASSIGNED_HOLDINGS AOAED ASPBG ATQHT AVWKF AZFZN CBCFC CEBXE CJUJL CRLBU CS3 DU5 EBS EDWGO EJD EMSAF EPQRW EQZZN F5P HAK IHE IJHAN IOP IZVLO JCGBZ KOT LAP M45 N5L N9A NT- NT. P2P PJBAE R4D RIN RNS RO9 ROL RPA SY9 UCJ W28 XPP ZMT AAYXX ADEQX AERVB CITATION .GJ 02O 1WK 29O AAGCF ACARI AHSEE ARNYC BBWZM CGR CUY CVF ECM EIF FEDTE HVGLF NPM Q02 RKQ S3P T37 7X8 AEINN 7QP 5PM |
| ID | FETCH-LOGICAL-c433t-df6e8cd28b552098bcfa3f762c29cf564cdc11d256a5dc8150d74dc8c6debf383 |
| IEDL.DBID | IOP |
| ISSN | 0967-3334 1361-6579 |
| IngestDate | Thu Aug 21 14:20:56 EDT 2025 Thu Sep 04 22:04:45 EDT 2025 Thu Sep 04 22:28:14 EDT 2025 Thu Apr 03 07:08:33 EDT 2025 Thu Apr 24 22:59:40 EDT 2025 Tue Jul 01 04:29:48 EDT 2025 Wed Aug 21 03:41:28 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| License | http://iopscience.iop.org/info/page/text-and-data-mining http://iopscience.iop.org/page/copyright |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c433t-df6e8cd28b552098bcfa3f762c29cf564cdc11d256a5dc8150d74dc8c6debf383 |
| Notes | Institute of Physics and Engineering in Medicine PMEA-100344.R1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 25154883 |
| PQID | 1558523764 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | crossref_citationtrail_10_1088_0967_3334_35_9_1899 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4388434 proquest_miscellaneous_1558523764 pubmed_primary_25154883 crossref_primary_10_1088_0967_3334_35_9_1899 proquest_miscellaneous_1654694620 iop_journals_10_1088_0967_3334_35_9_1899 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-09-01 |
| PublicationDateYYYYMMDD | 2014-09-01 |
| PublicationDate_xml | – month: 09 year: 2014 text: 2014-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Physiological measurement |
| PublicationTitleAbbrev | PM |
| PublicationTitleAlternate | Physiol. Meas |
| PublicationYear | 2014 |
| Publisher | IOP Publishing |
| Publisher_xml | – name: IOP Publishing |
| References | ICRP (10) 1975 22 23 24 25 Santos D (28) 2013 27 Aslam (2) 2009; 54 Hong L (9) 2013 29 30 Yildirim E A (32) 2009; 20 Wongwit W (31) 2004; 35 11 33 12 34 13 35 14 15 16 17 19 Rodier J (26) 1955; 12 1 3 4 Liu Y (18) 2013; 34 5 6 7 8 20 21 21662735 - Anal Chem. 1999 Dec 1;71(23):5379-85 12848244 - Int J Occup Environ Health. 2003 Apr-Jun;9(2):153-63 16382172 - Cardiovasc Toxicol. 2005 Fall;5(4):345-54 20012385 - Neuromolecular Med. 2009;11(4):311-21 22664337 - J Trace Elem Med Biol. 2012 Jun;26(2-3):179-82 21636558 - Radiat Prot Dosimetry. 2011 Jul;146(1-3):84-7 10592004 - Int Arch Occup Environ Health. 1999 Nov;72(8):521-7 5338081 - J Chronic Dis. 1966 May;19(5):545-71 20876035 - Environ Health Perspect. 2011 Feb;119(2):219-24 21840336 - Neurotoxicology. 2011 Oct;32(5):606-14 22975422 - Neurotoxicology. 2012 Oct;33(5):1356-61 14550763 - Regul Toxicol Pharmacol. 2003 Oct;38(2):232-42 21192973 - Neurotoxicology. 2011 Mar;32(2):171-9 17710609 - J Toxicol Environ Health B Crit Rev. 2007 Nov-Dec;10(6):417-65 16978697 - Neurotoxicology. 2007 Jan;28(1):126-35 1925437 - Scand J Work Environ Health. 1991 Aug;17(4):255-62 19757228 - Turk Psikiyatri Derg. 2009 Fall;20(3):294-8 20855239 - Environ Health Perspect. 2011 Jan;119(1):138-43 19753565 - Am J Ind Med. 2009 Oct;52(10):742-50 16337002 - Neurotoxicology. 2006 May;27(3):347-9 24184781 - Neurotoxicology. 2014 Jul;43:36-45 10774811 - Toxicol Sci. 2000 Apr;54(2):295-301 9505846 - Br J Radiol. 1997 Dec;70(840):1270-3 15617053 - NMR Biomed. 2004 Dec;17(8):544-53 19060358 - Phys Med Biol. 2009 Jan 7;54(1):17-28 14351643 - Br J Ind Med. 1955 Jan;12(1):21-35 17466353 - Toxicol Appl Pharmacol. 2007 Jun 1;221(2):131-47 15689101 - Southeast Asian J Trop Med Public Health. 2004 Sep;35(3):764-9 14637382 - Neurotoxicology. 2003 Dec;24(6):875-83 24165395 - Physiol Meas. 2013 Dec;34(12):1593-609 20946915 - Neurotoxicology. 2011 Jan;32(1):1-8 16766929 - J Occup Environ Med. 2006 Jun;48(6):644-9 |
| References_xml | – volume: 54 start-page: 17 issn: 0031-9155 year: 2009 ident: 2 publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/54/1/002 – ident: 17 doi: 10.1179/oeh.2003.9.2.153 – volume: 12 start-page: 21 issn: 0007-1072 year: 1955 ident: 26 publication-title: Br. J. Ind. Med. – volume: 20 start-page: 294 year: 2009 ident: 32 publication-title: Turk. Psikiyatri Derg. – ident: 6 doi: 10.1002/nbm.931 – ident: 20 doi: 10.1016/j.neuro.2005.11.002 – ident: 22 doi: 10.1093/rpd/ncr117 – ident: 4 doi: 10.1289/ehp.1002321 – start-page: 396 year: 2013 ident: 9 publication-title: The Toxicologist, Society of Toxicology (SOT) 2013 Annual Meeting Abstract – ident: 8 doi: 10.1016/S0273-2300(02)00020-X – ident: 35 doi: 10.1016/j.jtemb.2012.04.023 – ident: 33 doi: 10.1016/j.neuro.2010.10.002 – ident: 19 doi: 10.1007/s12017-009-8108-8 – ident: 12 doi: 10.1097/01.jom.0000204114.01893.3e – ident: 27 doi: 10.1080/15287390600975004 – volume: 34 start-page: 1593 issn: 0967-3334 year: 2013 ident: 18 publication-title: Physiol. Meas. doi: 10.1088/0967-3334/34/12/1593 – ident: 23 doi: 10.1093/rpd/ncr117 – ident: 7 doi: 10.1289/ehp.1002192 – ident: 16 doi: 10.1016/j.neuro.2010.12.014 – ident: 30 doi: 10.5271/sjweh.1705 – ident: 5 doi: 10.1021/ac990570l – year: 2013 ident: 28 publication-title: Neurotoxicology – ident: 24 doi: 10.1002/ajim.20737 – ident: 14 doi: 10.1016/j.neuro.2006.08.005 – ident: 29 doi: 10.1016/0021-9681(66)90094-4 – ident: 25 doi: 10.1016/j.neuro.2012.08.011 – ident: 1 doi: 10.1016/j.taap.2007.03.001 – ident: 13 doi: 10.1385/CT:5:4:345 – ident: 15 doi: 10.1016/j.neuro.2011.07.011 – volume: 35 start-page: 764 issn: 0125-1562 year: 2004 ident: 31 publication-title: Southeast Asian J. Trop. Med. Public Health – ident: 21 doi: 10.1016/S0161-813X(03)00082-2 – year: 1975 ident: 10 publication-title: Report of the Task Group on Reference Man. – ident: 3 doi: 10.1007/s004200050410 – ident: 34 doi: 10.1093/toxsci/54.2.295 – ident: 11 doi: 10.1259/bjr.70.840.9505846 – reference: 22664337 - J Trace Elem Med Biol. 2012 Jun;26(2-3):179-82 – reference: 10774811 - Toxicol Sci. 2000 Apr;54(2):295-301 – reference: 20876035 - Environ Health Perspect. 2011 Feb;119(2):219-24 – reference: 21636558 - Radiat Prot Dosimetry. 2011 Jul;146(1-3):84-7 – reference: 17466353 - Toxicol Appl Pharmacol. 2007 Jun 1;221(2):131-47 – reference: 19060358 - Phys Med Biol. 2009 Jan 7;54(1):17-28 – reference: 24184781 - Neurotoxicology. 2014 Jul;43:36-45 – reference: 16382172 - Cardiovasc Toxicol. 2005 Fall;5(4):345-54 – reference: 10592004 - Int Arch Occup Environ Health. 1999 Nov;72(8):521-7 – reference: 15689101 - Southeast Asian J Trop Med Public Health. 2004 Sep;35(3):764-9 – reference: 5338081 - J Chronic Dis. 1966 May;19(5):545-71 – reference: 9505846 - Br J Radiol. 1997 Dec;70(840):1270-3 – reference: 21192973 - Neurotoxicology. 2011 Mar;32(2):171-9 – reference: 24165395 - Physiol Meas. 2013 Dec;34(12):1593-609 – reference: 21840336 - Neurotoxicology. 2011 Oct;32(5):606-14 – reference: 14637382 - Neurotoxicology. 2003 Dec;24(6):875-83 – reference: 1925437 - Scand J Work Environ Health. 1991 Aug;17(4):255-62 – reference: 19753565 - Am J Ind Med. 2009 Oct;52(10):742-50 – reference: 20855239 - Environ Health Perspect. 2011 Jan;119(1):138-43 – reference: 16337002 - Neurotoxicology. 2006 May;27(3):347-9 – reference: 12848244 - Int J Occup Environ Health. 2003 Apr-Jun;9(2):153-63 – reference: 15617053 - NMR Biomed. 2004 Dec;17(8):544-53 – reference: 21662735 - Anal Chem. 1999 Dec 1;71(23):5379-85 – reference: 20012385 - Neuromolecular Med. 2009;11(4):311-21 – reference: 16766929 - J Occup Environ Med. 2006 Jun;48(6):644-9 – reference: 22975422 - Neurotoxicology. 2012 Oct;33(5):1356-61 – reference: 16978697 - Neurotoxicology. 2007 Jan;28(1):126-35 – reference: 17710609 - J Toxicol Environ Health B Crit Rev. 2007 Nov-Dec;10(6):417-65 – reference: 14351643 - Br J Ind Med. 1955 Jan;12(1):21-35 – reference: 20946915 - Neurotoxicology. 2011 Jan;32(1):1-8 – reference: 19757228 - Turk Psikiyatri Derg. 2009 Fall;20(3):294-8 – reference: 14550763 - Regul Toxicol Pharmacol. 2003 Oct;38(2):232-42 |
| SSID | ssj0011825 |
| Score | 2.1924956 |
| Snippet | A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in... A deuterium-deuterium (DD) neutron generator–based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in... |
| SourceID | pubmedcentral proquest pubmed crossref iop |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1899 |
| SubjectTerms | Bone and Bones - chemistry bone Mn Calcium - metabolism Calibration Computer Simulation DD nuetron generator Deuterium Equipment Design Gamma Rays Hand Humans in vivo Manganese - analysis Models, Biological Monte Carlo Method NAA Neutron Activation Analysis - instrumentation Neutron Activation Analysis - methods Neutrons Phantoms, Imaging Radiation Dosage |
| Title | A compact DD neutron generator-based NAA system to quantify manganese (Mn) in bone in vivo |
| URI | https://iopscience.iop.org/article/10.1088/0967-3334/35/9/1899 https://www.ncbi.nlm.nih.gov/pubmed/25154883 https://www.proquest.com/docview/1558523764 https://www.proquest.com/docview/1654694620 https://pubmed.ncbi.nlm.nih.gov/PMC4388434 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB7RIlB74LG0sLxkJA5FIrub2Mk6xxWlKkhbOFCp4mL5WVZAUmhSqfx6ZvJYdatqhTglUsZJPJ6JP8efPwO89tJmcSA9bYlJLmJsC2PzLAre5wjv04kOtHZ4fpQdHouPJ-lJ98OtWQtTnnWf_hGetkLBrQs7QpwcI-jGvOBcjHk6zscx3nIDbtPelRThHz59Xs4iIHZuKIx9gV516OabrPRMG_j0m0Dnde7klc7o4D6ovhotB-X7qK7MyP65pvD4__V8APc6nMpmrfVDuOWLAWxfUS8cwN15Ny8_gDsNkdSeP4KvM9bQ2m3F9vdZ4Wv61c5OG3FrHN5H1Gs6djSbsVZDmlUl-1Vroixdsp-6ONW0JSbbmxdv2KJgpiw8HS8WF-UOHB-8__LuMOr2b4is4LyKXMgwFFwiTUpkG2ls0Dzg19cmuQ1pJqyzcewQdOnUWYnQ1E0FntjMeRNw6LwLmwU-5gkwbbkRiZkGqxORTaTJea4laf0kIUjvhpD0badsJ25Oe2z8UM0ku5SKvKnIm4qnKlfkzSG8XRY6a7U91pvvYVOpLsfP15u-6iNHYbrSHAx6r6yxUIrjM2IiiTU2tMAsF1kyGcLjNtqW74dwFMeYkg9huhKHSwOSC1-9Uiy-NbLhgkspuHj679V4BluID0VLqXsOm9Xv2r9ADFaZl02i_QVs5CQt |
| linkProvider | IOP Publishing |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD5iQ0zwwKXcytVIPAxpaZrYTp3HilJtQMsemDTxYvkSjwpICksmwa_nOJeqnaYKiadYiu3Yxz725_jzZ4DXmTBJ5LyetkAnZxG2hTZpErgsSxHe86Fy_uzwbJ4cnrD3p_x0_SxMsWyH_gEGG6HgxoQtIU6ECLrRLyhlIeVhGkaYZbi0bgeucxyNPa3r6NPxaicB8XNNY-wSdcpDV2e0MTvtYAmuAp6X-ZNrE9L0DpiuKg0P5dugKvXA_Lmk8vh_db0Lt1u8SsZNintwLct7cGtNxbAHe7N2f74HN2pCqTm_D1_GpKa3m5JMJiTPKv_LnZzVIte4zA_87GnJfDwmjZY0KQvys1KeuvSb_FD5mfJXY5L9Wf6GLHKiizzzz4vFRfEATqbvPr89DNp7HALDKC0D6xLsEjYWmnvSjdDGKepwFDZxahxPmLEmiiyCL8WtEQhR7YhhwCQ20w6X0A9hN8fPPAaiDNUs1iNnVMySodApTZXwmj-xcyKzfYi79pOmFTn3d218l_VmuxDSW1R6i0rKZSq9RftwsEq0bDQ-tkffx-aSra-fb4_6qus9Et3W78Wg9YoKE3Fcp3lGEtsSxx80S1kSD_vwqOlxq_IhLMW1pqB9GG30xVUELxu--SZffK3lwxkVglH25N-r8RL2jidT-fFo_uEp3ETIyBqW3TPYLX9V2XOEZaV-UfvdX7XjKZE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+compact+DD+neutron+generator%E2%80%93based+NAA+system+to+quantify+manganese+%28Mn%29+in+bone+in+vivo&rft.jtitle=Physiological+measurement&rft.au=Liu%2C+Yingzi&rft.au=Byrne%2C+Patrick&rft.au=Wang%2C+Haoyu&rft.au=Koltick%2C+David&rft.date=2014-09-01&rft.issn=0967-3334&rft.eissn=1361-6579&rft.volume=35&rft.issue=9&rft.spage=1899&rft.epage=1911&rft_id=info:doi/10.1088%2F0967-3334%2F35%2F9%2F1899&rft.externalDBID=n%2Fa&rft.externalDocID=10_1088_0967_3334_35_9_1899 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0967-3334&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0967-3334&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0967-3334&client=summon |